Expression of atrial myosin light chains but not α-myosin heavy chains is correlated in vivo with increased ventricular function in patients with hypertrophic obstructive cardiomyopathy

The adult rodent heart adapts to increased work load by reexpression of its fetal genes, for example, beta-myosin heavy chain (MHC), in order to improve contractile function. However, the human ventricle regulates contractility by expression of atrial essential myosin light chain (ALC-1) rather than...

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Veröffentlicht in:	Journal of molecular medicine (Berlin, Germany) Germany), 1999-09, Vol.77 (9), p.677-685
Hauptverfasser:	RITTER, O, LUTHER, H. P, HAASE, H, BALTAS, L. G, BAUMANN, G, SCHULTE, H. D, MORANO, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Blotting, Western Calcium Channels, L-Type - metabolism Cardiology. Vascular system Cardiomyopathy, Hypertrophic - metabolism Female Heart Heart Atria - metabolism Humans Male Medical sciences Middle Aged Myocarditis. Cardiomyopathies Myosin Heavy Chains - biosynthesis Myosin Heavy Chains - genetics Myosin Light Chains - biosynthesis Myosin Light Chains - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Ryanodine Receptor Calcium Release Channel - metabolism Ventricular Function
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