Efficient Synthesis and Neuroprotective Effect of Substituted 1,3-Diphenyl-2-propen-1-ones

An efficient synthesis involving a key aldol reaction and biological properties of 1,3-diphenyl-2-propen-1-ones 8−20 is described. The in vitro activity for 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging of 10 and 11 was 2 times higher than that for resveratrol. Compounds 9 and 11 were the...

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Veröffentlicht in:	Journal of medicinal chemistry 2008-07, Vol.51 (13), p.4054-4058
Hauptverfasser:	Jung, Jae-Chul, Jang, Soyong, Lee, Yongnam, Min, Dongguk, Lim, Eunyoung, Jung, Heyin, Oh, Miyeon, Oh, Seikwan, Jung, Mankil
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - chemistry Animals Biological and medical sciences Cell Line Cell Survival - drug effects Chalcone - chemical synthesis Chalcone - chemistry Chalcone - pharmacology Glutarates - pharmacology Lipopolysaccharides - pharmacology Medical sciences Mice Models, Molecular Molecular Structure Neurons - drug effects Neurons - metabolism Neuropharmacology Neuroprotective agent Neuroprotective Agents - chemical synthesis Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology Nitric Oxide - biosynthesis Pharmacology. Drug treatments Structure-Activity Relationship Tissue Culture Techniques
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