Effect of peptide concentration and temperature on leuprolide stability in dimethyl sulfoxide

The effects of temperature and concentration on leuprolide degradation in dimethyl sulfoxide (DMSO) were explored. Leuprolide degradation products were analyzed by reverse phase high-performance liquid chromatography (RP–HPLC), size exclusion chromatography (SEC) and structurally characterized by ma...

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Veröffentlicht in:	International journal of pharmaceutics 1999-11, Vol.191 (2), p.115-129
Hauptverfasser:	Stevenson, Cynthia L, Leonard, John J, Hall, Steven C
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromatography, Gel Chromatography, High Pressure Liquid Dimethyl Sulfoxide - chemistry General pharmacology Humidity Hydrolysis Isomerism Leuprolide - chemistry Leuprolide acetate Mass Spectrometry Medical sciences Oxidation Oxidation-Reduction Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships RP–HPLC Solvents Temperature
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