Vascular endothelial growth factor and carotid intima-media thickness in patients with Behçet’s disease
There is morphologic evidence of subclinical atherosclerosis in Behçet’s disease (BD) patients obtained by high-resolution B-mode ultrasonography (US). Vascular endothelial growth factor (VEGF) is a potent angiogenetic factor and a marker for endothelial dysfunction. VEGF could contribute to the pat...
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| Veröffentlicht in: | Clinical rheumatology 2008-08, Vol.27 (8), p.961-966 |
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| creator | Öztürk, Mehmet Akif Ünverdi, Selman Oktar, Suna O. Bukan, Neslihan Gülbahar, Özlem Üreten, Kemal Göker, Berna Haznedaroglu, Seminur Sungur, Gülten Çiftçi, Tansu Ulukavak Onat, A. Mesut |
| description | There is morphologic evidence of subclinical atherosclerosis in Behçet’s disease (BD) patients obtained by high-resolution B-mode ultrasonography (US). Vascular endothelial growth factor (VEGF) is a potent angiogenetic factor and a marker for endothelial dysfunction. VEGF could contribute to the pathological events in BD. VEGF could also be an important factor in the progression of atherosclerosis. In this study, we investigated whether there is correlation between intima-media thickness (IMT) of the carotid arteries and serum VEGF levels in BD patients and healthy controls. Twenty-one patients with BD (male/female: 15/6, mean age: 35.8 ± 8.6 years) were individually matched to control subjects on the basis of age (within 3 years) and sex. Carotid IMT of the subjects was measured by high-resolution B-mode US. Mean IMT values of common carotid arteries were 0.86 ± 0.18 mm for patients with BD, and 0.57 ± 0.14 mm for healthy controls (
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| doi_str_mv | 10.1007/s10067-007-0825-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69283767</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69283767</sourcerecordid><originalsourceid>FETCH-LOGICAL-c299t-4cbde768c456b1d9753e2d0176a0dee4465e6d3f1e4f93a41f8884fe78cc3c923</originalsourceid><addsrcrecordid>eNp1kU-KFDEYxYMoTs_oAdxIcOEumn9VSZY6jI4w4EbdhnTy1XTa6qo2X4rBndfwBB7Em3gS03TDgOAm-Uh-7yW8R8gzwV8Jzs1rbGtvWBsZt7Jj3QOyElpp5px2D8mKG8OZEs6ekXPELedcWicekzNhJdfWdCuy_RIwLmMoFKY01w2MOYz0tsx3dUOHEOtcaJgSjaHMNSeap5p3ge0g5UDrJsevEyC2Y7oPNcNUkd7lJn0Lm9-_oP758RNpyggB4Ql5NIQR4elpvyCf3119urxmNx_ff7h8c8OidK4yHdcJTG-j7vq1SM50CmTiwvSBJwCt-w76pAYBenAqaDFYa_UAxsaoopPqgrw8-u7L_G0BrH6XMcI4hgnmBX3vpFWmNw188Q-4nZcytb95a4WyUqqDmzhCscyIBQa_Ly2B8t0L7g8t-GML_jAeWvBd0zw_GS_rltS94hR7A-QRwHY13UK5f_n_rn8BZvOVDg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>881382232</pqid></control><display><type>article</type><title>Vascular endothelial growth factor and carotid intima-media thickness in patients with Behçet’s disease</title><source>MEDLINE</source><source>Springer Online Journals Complete</source><creator>Öztürk, Mehmet Akif ; Ünverdi, Selman ; Oktar, Suna O. ; Bukan, Neslihan ; Gülbahar, Özlem ; Üreten, Kemal ; Göker, Berna ; Haznedaroglu, Seminur ; Sungur, Gülten ; Çiftçi, Tansu Ulukavak ; Onat, A. Mesut</creator><creatorcontrib>Öztürk, Mehmet Akif ; Ünverdi, Selman ; Oktar, Suna O. ; Bukan, Neslihan ; Gülbahar, Özlem ; Üreten, Kemal ; Göker, Berna ; Haznedaroglu, Seminur ; Sungur, Gülten ; Çiftçi, Tansu Ulukavak ; Onat, A. Mesut</creatorcontrib><description>There is morphologic evidence of subclinical atherosclerosis in Behçet’s disease (BD) patients obtained by high-resolution B-mode ultrasonography (US). Vascular endothelial growth factor (VEGF) is a potent angiogenetic factor and a marker for endothelial dysfunction. VEGF could contribute to the pathological events in BD. VEGF could also be an important factor in the progression of atherosclerosis. In this study, we investigated whether there is correlation between intima-media thickness (IMT) of the carotid arteries and serum VEGF levels in BD patients and healthy controls. Twenty-one patients with BD (male/female: 15/6, mean age: 35.8 ± 8.6 years) were individually matched to control subjects on the basis of age (within 3 years) and sex. Carotid IMT of the subjects was measured by high-resolution B-mode US. Mean IMT values of common carotid arteries were 0.86 ± 0.18 mm for patients with BD, and 0.57 ± 0.14 mm for healthy controls (
p
< 0.001). Mean VEGF levels were 130.41 ± 58.28 pg/ml for patients with BD and 82.69 ± 25.03 pg/ml for healthy controls (
p
< 0.001). There was no correlation between VEGF levels in the control group and in the BD group, but there was a significant correlation between VEGF levels and mean carotid IMT in the whole group (
r
= 0.317,
p
< 0.05). In conclusion, elevation of VEGF appears as a feature of the inflammatory reaction during the course of BD, not a direct determinant of subclinical atherosclerosis. On the other hand, the significant correlation between carotid IMT and serum VEGF levels in the whole group suggests that association between VEGF levels and carotid IMT warrants further investigation with larger sample sizes.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-007-0825-5</identifier><identifier>PMID: 18204875</identifier><language>eng</language><publisher>London: Springer-Verlag</publisher><subject>Adult ; Atherosclerosis ; Atherosclerosis - blood ; Atherosclerosis - complications ; Atherosclerosis - pathology ; Behcet Syndrome - blood ; Behcet Syndrome - complications ; Behcet Syndrome - pathology ; Biomarkers - blood ; Carotid Arteries - pathology ; Case-Control Studies ; Drug therapy ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Original Article ; Ovarian cancer ; Rheumatology ; Tunica Intima - pathology ; Tunica Media - pathology ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - blood</subject><ispartof>Clinical rheumatology, 2008-08, Vol.27 (8), p.961-966</ispartof><rights>Clinical Rheumatology 2007</rights><rights>Clinical Rheumatology 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c299t-4cbde768c456b1d9753e2d0176a0dee4465e6d3f1e4f93a41f8884fe78cc3c923</citedby><cites>FETCH-LOGICAL-c299t-4cbde768c456b1d9753e2d0176a0dee4465e6d3f1e4f93a41f8884fe78cc3c923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10067-007-0825-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10067-007-0825-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18204875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Öztürk, Mehmet Akif</creatorcontrib><creatorcontrib>Ünverdi, Selman</creatorcontrib><creatorcontrib>Oktar, Suna O.</creatorcontrib><creatorcontrib>Bukan, Neslihan</creatorcontrib><creatorcontrib>Gülbahar, Özlem</creatorcontrib><creatorcontrib>Üreten, Kemal</creatorcontrib><creatorcontrib>Göker, Berna</creatorcontrib><creatorcontrib>Haznedaroglu, Seminur</creatorcontrib><creatorcontrib>Sungur, Gülten</creatorcontrib><creatorcontrib>Çiftçi, Tansu Ulukavak</creatorcontrib><creatorcontrib>Onat, A. Mesut</creatorcontrib><title>Vascular endothelial growth factor and carotid intima-media thickness in patients with Behçet’s disease</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>There is morphologic evidence of subclinical atherosclerosis in Behçet’s disease (BD) patients obtained by high-resolution B-mode ultrasonography (US). Vascular endothelial growth factor (VEGF) is a potent angiogenetic factor and a marker for endothelial dysfunction. VEGF could contribute to the pathological events in BD. VEGF could also be an important factor in the progression of atherosclerosis. In this study, we investigated whether there is correlation between intima-media thickness (IMT) of the carotid arteries and serum VEGF levels in BD patients and healthy controls. Twenty-one patients with BD (male/female: 15/6, mean age: 35.8 ± 8.6 years) were individually matched to control subjects on the basis of age (within 3 years) and sex. Carotid IMT of the subjects was measured by high-resolution B-mode US. Mean IMT values of common carotid arteries were 0.86 ± 0.18 mm for patients with BD, and 0.57 ± 0.14 mm for healthy controls (
p
< 0.001). Mean VEGF levels were 130.41 ± 58.28 pg/ml for patients with BD and 82.69 ± 25.03 pg/ml for healthy controls (
p
< 0.001). There was no correlation between VEGF levels in the control group and in the BD group, but there was a significant correlation between VEGF levels and mean carotid IMT in the whole group (
r
= 0.317,
p
< 0.05). In conclusion, elevation of VEGF appears as a feature of the inflammatory reaction during the course of BD, not a direct determinant of subclinical atherosclerosis. On the other hand, the significant correlation between carotid IMT and serum VEGF levels in the whole group suggests that association between VEGF levels and carotid IMT warrants further investigation with larger sample sizes.</description><subject>Adult</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - blood</subject><subject>Atherosclerosis - complications</subject><subject>Atherosclerosis - pathology</subject><subject>Behcet Syndrome - blood</subject><subject>Behcet Syndrome - complications</subject><subject>Behcet Syndrome - pathology</subject><subject>Biomarkers - blood</subject><subject>Carotid Arteries - pathology</subject><subject>Case-Control Studies</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Ovarian cancer</subject><subject>Rheumatology</subject><subject>Tunica Intima - pathology</subject><subject>Tunica Media - pathology</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - blood</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU-KFDEYxYMoTs_oAdxIcOEumn9VSZY6jI4w4EbdhnTy1XTa6qo2X4rBndfwBB7Em3gS03TDgOAm-Uh-7yW8R8gzwV8Jzs1rbGtvWBsZt7Jj3QOyElpp5px2D8mKG8OZEs6ekXPELedcWicekzNhJdfWdCuy_RIwLmMoFKY01w2MOYz0tsx3dUOHEOtcaJgSjaHMNSeap5p3ge0g5UDrJsevEyC2Y7oPNcNUkd7lJn0Lm9-_oP758RNpyggB4Ql5NIQR4elpvyCf3119urxmNx_ff7h8c8OidK4yHdcJTG-j7vq1SM50CmTiwvSBJwCt-w76pAYBenAqaDFYa_UAxsaoopPqgrw8-u7L_G0BrH6XMcI4hgnmBX3vpFWmNw188Q-4nZcytb95a4WyUqqDmzhCscyIBQa_Ly2B8t0L7g8t-GML_jAeWvBd0zw_GS_rltS94hR7A-QRwHY13UK5f_n_rn8BZvOVDg</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Öztürk, Mehmet Akif</creator><creator>Ünverdi, Selman</creator><creator>Oktar, Suna O.</creator><creator>Bukan, Neslihan</creator><creator>Gülbahar, Özlem</creator><creator>Üreten, Kemal</creator><creator>Göker, Berna</creator><creator>Haznedaroglu, Seminur</creator><creator>Sungur, Gülten</creator><creator>Çiftçi, Tansu Ulukavak</creator><creator>Onat, A. Mesut</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20080801</creationdate><title>Vascular endothelial growth factor and carotid intima-media thickness in patients with Behçet’s disease</title><author>Öztürk, Mehmet Akif ; Ünverdi, Selman ; Oktar, Suna O. ; Bukan, Neslihan ; Gülbahar, Özlem ; Üreten, Kemal ; Göker, Berna ; Haznedaroglu, Seminur ; Sungur, Gülten ; Çiftçi, Tansu Ulukavak ; Onat, A. 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Mesut</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vascular endothelial growth factor and carotid intima-media thickness in patients with Behçet’s disease</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>27</volume><issue>8</issue><spage>961</spage><epage>966</epage><pages>961-966</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>There is morphologic evidence of subclinical atherosclerosis in Behçet’s disease (BD) patients obtained by high-resolution B-mode ultrasonography (US). Vascular endothelial growth factor (VEGF) is a potent angiogenetic factor and a marker for endothelial dysfunction. VEGF could contribute to the pathological events in BD. VEGF could also be an important factor in the progression of atherosclerosis. In this study, we investigated whether there is correlation between intima-media thickness (IMT) of the carotid arteries and serum VEGF levels in BD patients and healthy controls. Twenty-one patients with BD (male/female: 15/6, mean age: 35.8 ± 8.6 years) were individually matched to control subjects on the basis of age (within 3 years) and sex. Carotid IMT of the subjects was measured by high-resolution B-mode US. Mean IMT values of common carotid arteries were 0.86 ± 0.18 mm for patients with BD, and 0.57 ± 0.14 mm for healthy controls (
p
< 0.001). Mean VEGF levels were 130.41 ± 58.28 pg/ml for patients with BD and 82.69 ± 25.03 pg/ml for healthy controls (
p
< 0.001). There was no correlation between VEGF levels in the control group and in the BD group, but there was a significant correlation between VEGF levels and mean carotid IMT in the whole group (
r
= 0.317,
p
< 0.05). In conclusion, elevation of VEGF appears as a feature of the inflammatory reaction during the course of BD, not a direct determinant of subclinical atherosclerosis. On the other hand, the significant correlation between carotid IMT and serum VEGF levels in the whole group suggests that association between VEGF levels and carotid IMT warrants further investigation with larger sample sizes.</abstract><cop>London</cop><pub>Springer-Verlag</pub><pmid>18204875</pmid><doi>10.1007/s10067-007-0825-5</doi><tpages>6</tpages></addata></record> |
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| language | eng |
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| subjects | Adult Atherosclerosis Atherosclerosis - blood Atherosclerosis - complications Atherosclerosis - pathology Behcet Syndrome - blood Behcet Syndrome - complications Behcet Syndrome - pathology Biomarkers - blood Carotid Arteries - pathology Case-Control Studies Drug therapy Female Humans Male Medicine Medicine & Public Health Original Article Ovarian cancer Rheumatology Tunica Intima - pathology Tunica Media - pathology Vascular endothelial growth factor Vascular Endothelial Growth Factor A - blood |
| title | Vascular endothelial growth factor and carotid intima-media thickness in patients with Behçet’s disease |
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