Genomic characterization of the sheep vasopressin V1a receptor gene and promoter, with assignment to bands q23–24 of sheep chromosome 3 and cattle chromosome 5
Arginine vasopressin interacts with the vasopressin type 1a receptor (V1aR) to initiate physiological effects such as vasoconstriction of blood vessels and glycogenolysis. AVP is also involved in central nervous effects such as body homeostasis and blood pressure control. The complete genomic organi...
Gespeichert in:
| Veröffentlicht in: | Gene 1999-11, Vol.240 (1), p.183-192 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 192 |
|---|---|
| container_issue | 1 |
| container_start_page | 183 |
| container_title | Gene |
| container_volume | 240 |
| creator | Koukoulas, Irene Webb, Graham C. Bottema, Cynthia D.K. Gill, Clare Johnston, Colin I. Aldred, G.Peter |
| description | Arginine vasopressin interacts with the vasopressin type 1a receptor (V1aR) to initiate physiological effects such as vasoconstriction of blood vessels and glycogenolysis. AVP is also involved in central nervous effects such as body homeostasis and blood pressure control. The complete genomic organization of the sheep V1aR gene has been determined, including the presence of one major and two minor transcriptional start sites at −321, −206 and −91
bp respectively, relative to the ATG codon. Another more distal minor transcriptional start site was also localized between nucleotides −997 and −892 relative to the ATG codon. One intron exists in the sheep V1aR gene and potential
cis- and
trans- acting sites were identified in the sheep V1aR promoter. The promoter was also compared to the rat V1aR promoter. The sheep V1aR promoter displays features typical of housekeeping genes, although tissue-specific expression does not support this. V1aR mRNA is absent in the adult sheep liver but not the kidney. One copy of the V1aR gene exists in the sheep genome, which was localized to chromosome 3q23–24, and to the homoeologous position, 5q23–24 in cattle. |
| doi_str_mv | 10.1016/S0378-1119(99)00407-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69283614</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378111999004072</els_id><sourcerecordid>17404371</sourcerecordid><originalsourceid>FETCH-LOGICAL-c416t-43e607b56b0fd0fe4804d4a4fd68d9ffb58acc6697dbd81385d4da26fb1f37e93</originalsourceid><addsrcrecordid>eNqFkcFuFCEYx4nR2HX1EVROpiaOwsAww6kxjVaTJh5qvRIGPnYwO8MU2Bp78h18Al_NJ5HdaUxv5UJCfv8_H_wQek7JW0qoeHdBWNtVlFJ5LOVrQjhpq_oBWtGulRUhrHuIVv-RI_Qkpe-krKapH6MjShrBu7pZoT9nMIXRG2wGHbXJEP2Nzj5MODicB8BpAJjxtU5hjpCSn_A3qnEEA3MOEW9gAqwni-cYxlDib_APnwesC7qZRpgyzgH3hUj4qmZ_f_2u-b56qTXDPpXCCJgdWozOeQt3z5un6JHT2wTPbvc1uvz44evpp-r8y9nn0_fnleFU5IozEKTtG9ETZ4kD3hFuuebOis5K5_qm08YIIVvb246yrrHc6lq4njrWgmRr9GrpLS-52kHKavTJwHarJwi7pISsOyYovxekLSectbSAzQKaGFKK4NQc_ajjT0WJ2ktUB4lqb0hJqQ4SVV1yL24v2PUj2DupxVoBXi6A00HpTfRJXV7UhDJSSyqbMucanSwElB-79hBVMh4mA9YXdVnZ4O8Z4h-hKLhu</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17404371</pqid></control><display><type>article</type><title>Genomic characterization of the sheep vasopressin V1a receptor gene and promoter, with assignment to bands q23–24 of sheep chromosome 3 and cattle chromosome 5</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Koukoulas, Irene ; Webb, Graham C. ; Bottema, Cynthia D.K. ; Gill, Clare ; Johnston, Colin I. ; Aldred, G.Peter</creator><creatorcontrib>Koukoulas, Irene ; Webb, Graham C. ; Bottema, Cynthia D.K. ; Gill, Clare ; Johnston, Colin I. ; Aldred, G.Peter</creatorcontrib><description>Arginine vasopressin interacts with the vasopressin type 1a receptor (V1aR) to initiate physiological effects such as vasoconstriction of blood vessels and glycogenolysis. AVP is also involved in central nervous effects such as body homeostasis and blood pressure control. The complete genomic organization of the sheep V1aR gene has been determined, including the presence of one major and two minor transcriptional start sites at −321, −206 and −91
bp respectively, relative to the ATG codon. Another more distal minor transcriptional start site was also localized between nucleotides −997 and −892 relative to the ATG codon. One intron exists in the sheep V1aR gene and potential
cis- and
trans- acting sites were identified in the sheep V1aR promoter. The promoter was also compared to the rat V1aR promoter. The sheep V1aR promoter displays features typical of housekeeping genes, although tissue-specific expression does not support this. V1aR mRNA is absent in the adult sheep liver but not the kidney. One copy of the V1aR gene exists in the sheep genome, which was localized to chromosome 3q23–24, and to the homoeologous position, 5q23–24 in cattle.</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/S0378-1119(99)00407-2</identifier><identifier>PMID: 10564825</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Amino Acid Sequence ; amino acid sequences ; Animals ; Arginine vasopressin ; Base Sequence ; Blotting, Southern ; Cattle ; chromosome 3 ; chromosome 5 ; Chromosome Banding ; Chromosome Mapping ; chromosomes ; Chromosomes - genetics ; DNA - chemistry ; DNA - genetics ; Exons ; fluorescence in situ hybridization ; genbank/af118390 ; gene expression ; gene location ; Gene mapping ; genes ; Genes - genetics ; Genomic organization ; hormone receptors ; In Situ Hybridization, Fluorescence ; Introns ; messenger RNA ; Molecular Sequence Data ; nucleic acid hybridization ; nucleotide sequences ; promoter regions ; Promoter Regions, Genetic ; Rats ; Receptors, Vasopressin - genetics ; Regulatory region ; Sequence Alignment ; Sequence Analysis, DNA ; Sequence Homology, Nucleic Acid ; sheep ; Sheep - genetics ; species differences ; Transcription factor ; Transcription, Genetic ; V1aR gene ; vasopressin ; vasopressin V1a receptors</subject><ispartof>Gene, 1999-11, Vol.240 (1), p.183-192</ispartof><rights>1999 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-43e607b56b0fd0fe4804d4a4fd68d9ffb58acc6697dbd81385d4da26fb1f37e93</citedby><cites>FETCH-LOGICAL-c416t-43e607b56b0fd0fe4804d4a4fd68d9ffb58acc6697dbd81385d4da26fb1f37e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378111999004072$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10564825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koukoulas, Irene</creatorcontrib><creatorcontrib>Webb, Graham C.</creatorcontrib><creatorcontrib>Bottema, Cynthia D.K.</creatorcontrib><creatorcontrib>Gill, Clare</creatorcontrib><creatorcontrib>Johnston, Colin I.</creatorcontrib><creatorcontrib>Aldred, G.Peter</creatorcontrib><title>Genomic characterization of the sheep vasopressin V1a receptor gene and promoter, with assignment to bands q23–24 of sheep chromosome 3 and cattle chromosome 5</title><title>Gene</title><addtitle>Gene</addtitle><description>Arginine vasopressin interacts with the vasopressin type 1a receptor (V1aR) to initiate physiological effects such as vasoconstriction of blood vessels and glycogenolysis. AVP is also involved in central nervous effects such as body homeostasis and blood pressure control. The complete genomic organization of the sheep V1aR gene has been determined, including the presence of one major and two minor transcriptional start sites at −321, −206 and −91
bp respectively, relative to the ATG codon. Another more distal minor transcriptional start site was also localized between nucleotides −997 and −892 relative to the ATG codon. One intron exists in the sheep V1aR gene and potential
cis- and
trans- acting sites were identified in the sheep V1aR promoter. The promoter was also compared to the rat V1aR promoter. The sheep V1aR promoter displays features typical of housekeeping genes, although tissue-specific expression does not support this. V1aR mRNA is absent in the adult sheep liver but not the kidney. One copy of the V1aR gene exists in the sheep genome, which was localized to chromosome 3q23–24, and to the homoeologous position, 5q23–24 in cattle.</description><subject>Amino Acid Sequence</subject><subject>amino acid sequences</subject><subject>Animals</subject><subject>Arginine vasopressin</subject><subject>Base Sequence</subject><subject>Blotting, Southern</subject><subject>Cattle</subject><subject>chromosome 3</subject><subject>chromosome 5</subject><subject>Chromosome Banding</subject><subject>Chromosome Mapping</subject><subject>chromosomes</subject><subject>Chromosomes - genetics</subject><subject>DNA - chemistry</subject><subject>DNA - genetics</subject><subject>Exons</subject><subject>fluorescence in situ hybridization</subject><subject>genbank/af118390</subject><subject>gene expression</subject><subject>gene location</subject><subject>Gene mapping</subject><subject>genes</subject><subject>Genes - genetics</subject><subject>Genomic organization</subject><subject>hormone receptors</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Introns</subject><subject>messenger RNA</subject><subject>Molecular Sequence Data</subject><subject>nucleic acid hybridization</subject><subject>nucleotide sequences</subject><subject>promoter regions</subject><subject>Promoter Regions, Genetic</subject><subject>Rats</subject><subject>Receptors, Vasopressin - genetics</subject><subject>Regulatory region</subject><subject>Sequence Alignment</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>sheep</subject><subject>Sheep - genetics</subject><subject>species differences</subject><subject>Transcription factor</subject><subject>Transcription, Genetic</subject><subject>V1aR gene</subject><subject>vasopressin</subject><subject>vasopressin V1a receptors</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFuFCEYx4nR2HX1EVROpiaOwsAww6kxjVaTJh5qvRIGPnYwO8MU2Bp78h18Al_NJ5HdaUxv5UJCfv8_H_wQek7JW0qoeHdBWNtVlFJ5LOVrQjhpq_oBWtGulRUhrHuIVv-RI_Qkpe-krKapH6MjShrBu7pZoT9nMIXRG2wGHbXJEP2Nzj5MODicB8BpAJjxtU5hjpCSn_A3qnEEA3MOEW9gAqwni-cYxlDib_APnwesC7qZRpgyzgH3hUj4qmZ_f_2u-b56qTXDPpXCCJgdWozOeQt3z5un6JHT2wTPbvc1uvz44evpp-r8y9nn0_fnleFU5IozEKTtG9ETZ4kD3hFuuebOis5K5_qm08YIIVvb246yrrHc6lq4njrWgmRr9GrpLS-52kHKavTJwHarJwi7pISsOyYovxekLSectbSAzQKaGFKK4NQc_ajjT0WJ2ktUB4lqb0hJqQ4SVV1yL24v2PUj2DupxVoBXi6A00HpTfRJXV7UhDJSSyqbMucanSwElB-79hBVMh4mA9YXdVnZ4O8Z4h-hKLhu</recordid><startdate>19991115</startdate><enddate>19991115</enddate><creator>Koukoulas, Irene</creator><creator>Webb, Graham C.</creator><creator>Bottema, Cynthia D.K.</creator><creator>Gill, Clare</creator><creator>Johnston, Colin I.</creator><creator>Aldred, G.Peter</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19991115</creationdate><title>Genomic characterization of the sheep vasopressin V1a receptor gene and promoter, with assignment to bands q23–24 of sheep chromosome 3 and cattle chromosome 5</title><author>Koukoulas, Irene ; Webb, Graham C. ; Bottema, Cynthia D.K. ; Gill, Clare ; Johnston, Colin I. ; Aldred, G.Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-43e607b56b0fd0fe4804d4a4fd68d9ffb58acc6697dbd81385d4da26fb1f37e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Amino Acid Sequence</topic><topic>amino acid sequences</topic><topic>Animals</topic><topic>Arginine vasopressin</topic><topic>Base Sequence</topic><topic>Blotting, Southern</topic><topic>Cattle</topic><topic>chromosome 3</topic><topic>chromosome 5</topic><topic>Chromosome Banding</topic><topic>Chromosome Mapping</topic><topic>chromosomes</topic><topic>Chromosomes - genetics</topic><topic>DNA - chemistry</topic><topic>DNA - genetics</topic><topic>Exons</topic><topic>fluorescence in situ hybridization</topic><topic>genbank/af118390</topic><topic>gene expression</topic><topic>gene location</topic><topic>Gene mapping</topic><topic>genes</topic><topic>Genes - genetics</topic><topic>Genomic organization</topic><topic>hormone receptors</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Introns</topic><topic>messenger RNA</topic><topic>Molecular Sequence Data</topic><topic>nucleic acid hybridization</topic><topic>nucleotide sequences</topic><topic>promoter regions</topic><topic>Promoter Regions, Genetic</topic><topic>Rats</topic><topic>Receptors, Vasopressin - genetics</topic><topic>Regulatory region</topic><topic>Sequence Alignment</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>sheep</topic><topic>Sheep - genetics</topic><topic>species differences</topic><topic>Transcription factor</topic><topic>Transcription, Genetic</topic><topic>V1aR gene</topic><topic>vasopressin</topic><topic>vasopressin V1a receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koukoulas, Irene</creatorcontrib><creatorcontrib>Webb, Graham C.</creatorcontrib><creatorcontrib>Bottema, Cynthia D.K.</creatorcontrib><creatorcontrib>Gill, Clare</creatorcontrib><creatorcontrib>Johnston, Colin I.</creatorcontrib><creatorcontrib>Aldred, G.Peter</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koukoulas, Irene</au><au>Webb, Graham C.</au><au>Bottema, Cynthia D.K.</au><au>Gill, Clare</au><au>Johnston, Colin I.</au><au>Aldred, G.Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genomic characterization of the sheep vasopressin V1a receptor gene and promoter, with assignment to bands q23–24 of sheep chromosome 3 and cattle chromosome 5</atitle><jtitle>Gene</jtitle><addtitle>Gene</addtitle><date>1999-11-15</date><risdate>1999</risdate><volume>240</volume><issue>1</issue><spage>183</spage><epage>192</epage><pages>183-192</pages><issn>0378-1119</issn><eissn>1879-0038</eissn><abstract>Arginine vasopressin interacts with the vasopressin type 1a receptor (V1aR) to initiate physiological effects such as vasoconstriction of blood vessels and glycogenolysis. AVP is also involved in central nervous effects such as body homeostasis and blood pressure control. The complete genomic organization of the sheep V1aR gene has been determined, including the presence of one major and two minor transcriptional start sites at −321, −206 and −91
bp respectively, relative to the ATG codon. Another more distal minor transcriptional start site was also localized between nucleotides −997 and −892 relative to the ATG codon. One intron exists in the sheep V1aR gene and potential
cis- and
trans- acting sites were identified in the sheep V1aR promoter. The promoter was also compared to the rat V1aR promoter. The sheep V1aR promoter displays features typical of housekeeping genes, although tissue-specific expression does not support this. V1aR mRNA is absent in the adult sheep liver but not the kidney. One copy of the V1aR gene exists in the sheep genome, which was localized to chromosome 3q23–24, and to the homoeologous position, 5q23–24 in cattle.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>10564825</pmid><doi>10.1016/S0378-1119(99)00407-2</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-1119 |
| ispartof | Gene, 1999-11, Vol.240 (1), p.183-192 |
| issn | 0378-1119 1879-0038 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69283614 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Amino Acid Sequence amino acid sequences Animals Arginine vasopressin Base Sequence Blotting, Southern Cattle chromosome 3 chromosome 5 Chromosome Banding Chromosome Mapping chromosomes Chromosomes - genetics DNA - chemistry DNA - genetics Exons fluorescence in situ hybridization genbank/af118390 gene expression gene location Gene mapping genes Genes - genetics Genomic organization hormone receptors In Situ Hybridization, Fluorescence Introns messenger RNA Molecular Sequence Data nucleic acid hybridization nucleotide sequences promoter regions Promoter Regions, Genetic Rats Receptors, Vasopressin - genetics Regulatory region Sequence Alignment Sequence Analysis, DNA Sequence Homology, Nucleic Acid sheep Sheep - genetics species differences Transcription factor Transcription, Genetic V1aR gene vasopressin vasopressin V1a receptors |
| title | Genomic characterization of the sheep vasopressin V1a receptor gene and promoter, with assignment to bands q23–24 of sheep chromosome 3 and cattle chromosome 5 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T17%3A26%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genomic%20characterization%20of%20the%20sheep%20vasopressin%20V1a%20receptor%20gene%20and%20promoter,%20with%20assignment%20to%20bands%20q23%E2%80%9324%20of%20sheep%20chromosome%203%20and%20cattle%20chromosome%205&rft.jtitle=Gene&rft.au=Koukoulas,%20Irene&rft.date=1999-11-15&rft.volume=240&rft.issue=1&rft.spage=183&rft.epage=192&rft.pages=183-192&rft.issn=0378-1119&rft.eissn=1879-0038&rft_id=info:doi/10.1016/S0378-1119(99)00407-2&rft_dat=%3Cproquest_cross%3E17404371%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17404371&rft_id=info:pmid/10564825&rft_els_id=S0378111999004072&rfr_iscdi=true |