Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts

Microtubules are involved in actin-based protrusion at the leading-edge lamellipodia of migrating fibroblasts. Here we show that the growth of microtubules induced in fibroblasts by removal of the microtubule destabilizer nocodazole activates Rac1 GTPase, leading to the polymerization of actin in la...

Ausführliche Beschreibung