Tetraploid Acute Promyelocytic Leukemia with Large Bizarre Blast Cell Morphology
We describe a case of atypical acute promyelocytic leukemia (APL) with a tetraploid clone and multiple karyotypic abnormalities in addition to the translocation (15;17)(q22;q21). Microscopically, the leukemic cells were highly heterogeneous in morphology and granularity, being bizarre and large in s...
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| Veröffentlicht in: | Cancer genetics and cytogenetics 1999-11, Vol.115 (1), p.52-55 |
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| container_title | Cancer genetics and cytogenetics |
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| creator | Au, W.Y Ma, S.K Lam, C.C.K Chan, L.C Kwong, Y.L |
| description | We describe a case of atypical acute promyelocytic leukemia (APL) with a tetraploid clone and multiple karyotypic abnormalities in addition to the translocation (15;17)(q22;q21). Microscopically, the leukemic cells were highly heterogeneous in morphology and granularity, being bizarre and large in size compared with classical APL blasts. The patient responded to treatment with chemotherapy and all-
trans-retinoic acid, at diagnosis and at relapse 10 months later. He is currently in clinical and molecular remission, 3 years after initial diagnosis. Tetraploidy in association with large and bizarre blasts has not been previously reported in APL. Although tetraploidy and complex karyotypic aberrations confer a poor prognosis in other types of acute myeloid leukemia, in the presence of t(15;17) they did not appear to affect the prognosis, inasmuch as the clinical features and treatment outcome in our case followed those of APL in general. |
| doi_str_mv | 10.1016/S0165-4608(99)00066-7 |
| format | Article |
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trans-retinoic acid, at diagnosis and at relapse 10 months later. He is currently in clinical and molecular remission, 3 years after initial diagnosis. Tetraploidy in association with large and bizarre blasts has not been previously reported in APL. Although tetraploidy and complex karyotypic aberrations confer a poor prognosis in other types of acute myeloid leukemia, in the presence of t(15;17) they did not appear to affect the prognosis, inasmuch as the clinical features and treatment outcome in our case followed those of APL in general.</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/S0165-4608(99)00066-7</identifier><identifier>PMID: 10565300</identifier><identifier>CODEN: CGCYDF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aneuploidy ; Biological and medical sciences ; Bone Marrow Cells - pathology ; Chromosomes, Human, Pair 15 ; Chromosomes, Human, Pair 17 ; Hematologic and hematopoietic diseases ; Humans ; Karyotyping ; Leukemia, Promyelocytic, Acute - drug therapy ; Leukemia, Promyelocytic, Acute - genetics ; Leukemia, Promyelocytic, Acute - pathology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Translocation, Genetic</subject><ispartof>Cancer genetics and cytogenetics, 1999-11, Vol.115 (1), p.52-55</ispartof><rights>1999 Elsevier Science Inc.</rights><rights>2000 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-e2647b8aa3328e9274fe0cb9ee7dd2ff48318159a647b723f72d7ca8b238c5503</citedby><cites>FETCH-LOGICAL-c419t-e2647b8aa3328e9274fe0cb9ee7dd2ff48318159a647b723f72d7ca8b238c5503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0165-4608(99)00066-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1192608$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10565300$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Au, W.Y</creatorcontrib><creatorcontrib>Ma, S.K</creatorcontrib><creatorcontrib>Lam, C.C.K</creatorcontrib><creatorcontrib>Chan, L.C</creatorcontrib><creatorcontrib>Kwong, Y.L</creatorcontrib><title>Tetraploid Acute Promyelocytic Leukemia with Large Bizarre Blast Cell Morphology</title><title>Cancer genetics and cytogenetics</title><addtitle>Cancer Genet Cytogenet</addtitle><description>We describe a case of atypical acute promyelocytic leukemia (APL) with a tetraploid clone and multiple karyotypic abnormalities in addition to the translocation (15;17)(q22;q21). Microscopically, the leukemic cells were highly heterogeneous in morphology and granularity, being bizarre and large in size compared with classical APL blasts. The patient responded to treatment with chemotherapy and all-
trans-retinoic acid, at diagnosis and at relapse 10 months later. He is currently in clinical and molecular remission, 3 years after initial diagnosis. Tetraploidy in association with large and bizarre blasts has not been previously reported in APL. Although tetraploidy and complex karyotypic aberrations confer a poor prognosis in other types of acute myeloid leukemia, in the presence of t(15;17) they did not appear to affect the prognosis, inasmuch as the clinical features and treatment outcome in our case followed those of APL in general.</description><subject>Adult</subject><subject>Aneuploidy</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Cells - pathology</subject><subject>Chromosomes, Human, Pair 15</subject><subject>Chromosomes, Human, Pair 17</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Leukemia, Promyelocytic, Acute - drug therapy</subject><subject>Leukemia, Promyelocytic, Acute - genetics</subject><subject>Leukemia, Promyelocytic, Acute - pathology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Translocation, Genetic</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EgvL4BFAWCMEiYDuJHytUKl5SEZUoa8t1JmBI6mInoPL1uLQCdmzmbs7MXB2E9gk-JZiws4c4ijRnWBxLeYIxZizla6hHBM_SPC_YOur9IFtoO4SXCHEq2SbaIrhgRYZxD43G0Ho9q50tk77pWkhG3jVzqJ2Zt9YkQ-heobE6-bDtczLU_gmSC_upvY9Z69AmA6jr5M752bOr3dN8F21Uug6wt8od9Hh1OR7cpMP769tBf5ianMg2BcpyPhFaZxkVICnPK8BmIgF4WdKqykVGBCmkXmCcZhWnJTdaTGgmTFHgbAcdLe_OvHvrILSqscHELnoKrguKSSoopyKCxRI03oXgoVIzbxvt54pgtVCpvlWqhSclpfpWqXjcO1g96CYNlH-2lu4icLgCdDC6rryeGht-OSJpPBmx8yUG0ca7Ba-CsTA1UFoPplWls_80-QKebY_E</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>Au, W.Y</creator><creator>Ma, S.K</creator><creator>Lam, C.C.K</creator><creator>Chan, L.C</creator><creator>Kwong, Y.L</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991101</creationdate><title>Tetraploid Acute Promyelocytic Leukemia with Large Bizarre Blast Cell Morphology</title><author>Au, W.Y ; Ma, S.K ; Lam, C.C.K ; Chan, L.C ; Kwong, Y.L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-e2647b8aa3328e9274fe0cb9ee7dd2ff48318159a647b723f72d7ca8b238c5503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Aneuploidy</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Cells - pathology</topic><topic>Chromosomes, Human, Pair 15</topic><topic>Chromosomes, Human, Pair 17</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Leukemia, Promyelocytic, Acute - drug therapy</topic><topic>Leukemia, Promyelocytic, Acute - genetics</topic><topic>Leukemia, Promyelocytic, Acute - pathology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Translocation, Genetic</topic><toplevel>online_resources</toplevel><creatorcontrib>Au, W.Y</creatorcontrib><creatorcontrib>Ma, S.K</creatorcontrib><creatorcontrib>Lam, C.C.K</creatorcontrib><creatorcontrib>Chan, L.C</creatorcontrib><creatorcontrib>Kwong, Y.L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Au, W.Y</au><au>Ma, S.K</au><au>Lam, C.C.K</au><au>Chan, L.C</au><au>Kwong, Y.L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tetraploid Acute Promyelocytic Leukemia with Large Bizarre Blast Cell Morphology</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>115</volume><issue>1</issue><spage>52</spage><epage>55</epage><pages>52-55</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><coden>CGCYDF</coden><abstract>We describe a case of atypical acute promyelocytic leukemia (APL) with a tetraploid clone and multiple karyotypic abnormalities in addition to the translocation (15;17)(q22;q21). 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trans-retinoic acid, at diagnosis and at relapse 10 months later. He is currently in clinical and molecular remission, 3 years after initial diagnosis. Tetraploidy in association with large and bizarre blasts has not been previously reported in APL. Although tetraploidy and complex karyotypic aberrations confer a poor prognosis in other types of acute myeloid leukemia, in the presence of t(15;17) they did not appear to affect the prognosis, inasmuch as the clinical features and treatment outcome in our case followed those of APL in general.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10565300</pmid><doi>10.1016/S0165-4608(99)00066-7</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Aneuploidy Biological and medical sciences Bone Marrow Cells - pathology Chromosomes, Human, Pair 15 Chromosomes, Human, Pair 17 Hematologic and hematopoietic diseases Humans Karyotyping Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - genetics Leukemia, Promyelocytic, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Translocation, Genetic |
| title | Tetraploid Acute Promyelocytic Leukemia with Large Bizarre Blast Cell Morphology |
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