A Novel Anti-Apoptosis Gene: Re-expression of Survivin Messenger RNA as a Prognosis Marker in Non–Small-Cell Lung Cancers

The survivin gene is a novel apoptosis inhibitor, related to the baculovirus gene, which is believed to play a pivotal role in fetal development and in cancer. We hypothesised that survivin would be expressed in tumors of patients with non-small-cell lung cancer (NSCLC), and we attempted to determin...

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Veröffentlicht in:	Journal of clinical oncology 1999-07, Vol.17 (7), p.2100-2104
Hauptverfasser:	MONZ, M, ROSELL, R, FELIP, E, ASTUDILLO, J, SANCHEZ, J. J, MAESTRE, J, MARTIN, C, FONT, A, BARNADAS, A, ABAD, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Biomarkers, Tumor - metabolism Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Female Humans Inhibitor of Apoptosis Proteins Lung Neoplasms - diagnosis Lung Neoplasms - genetics Lung Neoplasms - mortality Male Medical sciences Microtubule-Associated Proteins Middle Aged Neoplasm Proteins Pneumology Prognosis Proportional Hazards Models Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Spain - epidemiology Statistics, Nonparametric Survival Analysis Survival Rate Tumors of the respiratory system and mediastinum
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