Granulocyte elastase and systemic cytokine response after laparoscopic-assisted and open resections in Crohn's disease
The aim of this study was to assess whether systemic proinflammatory cytokines (IL-6), anti-inflammatory cytokines (IL-4, IL-10), acute phase proteins (C-reactive protein), or granulocyte elastase are valuable indicators for determining the degree of surgical trauma after open vs. laparoscopic-assis...
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| Veröffentlicht in: | Diseases of the colon & rectum 1999-11, Vol.42 (11), p.1480-1486 |
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| creator | HILDEBRANDT, U KESSLER, K PISTORIUS, G LINDEMANN, W ECKER, K. W FEIFEL, G MENGER, M. D |
| description | The aim of this study was to assess whether systemic proinflammatory cytokines (IL-6), anti-inflammatory cytokines (IL-4, IL-10), acute phase proteins (C-reactive protein), or granulocyte elastase are valuable indicators for determining the degree of surgical trauma after open vs. laparoscopic-assisted resections in Crohn's disease.
Eleven patients in each group (open and laparoscopic-assisted surgery) were matched for indication, surgical procedure, and Crohn's disease activity index. Serum IL-4, IL-6, and IL-10 were measured using enzyme-linked immunosorbent assay. Serum C-reactive protein was determined by immunoturbidimetric assay. Plasma granulocyte elastase was determined by immunoactivation immunoassay. Blood was sampled preoperatively, six hours after the operation, and at postoperative Days 1 to 5.
IL-4 was not detectable in any sample analyzed. Serum IL-6 and IL-10 levels peaked postoperatively in both groups without significant differences between laparoscopic-assisted (185.6 +/-54.1 pg/ml and 112.1 +/- 19.4 pg/ml, respectively; mean +/-standard error of the mean) and open surgery (431.1 +/-240.4 pg/ml and 196.7 +/- 56.5 pg/ml, respectively). Serum C-reactive protein levels also rose postoperatively, with a peak on the second day, but showed similar values after laparoscopic-assisted (107.1 +/- 12.1 mg/l) and open (128.3 +/- 17.5 mg/l) surgery. Plasma granulocyte elastase levels peaked on the first and second postoperative day and were found elevated almost throughout the five-day observation period. Comparison between the groups revealed significantly (P < 0.02) lower values after laparoscopic-assisted (Day 1, 46.5 +/- 8.9 microg/l; Day 2, 41.9 +/- 5.9 microg/l) when compared with open surgery (Day 1, 89.7 +/- 13.8 microg/l; Day 2, 91.4 +/- 14).
Serum IL-6 and IL-10 may not be ideal measures for evaluation of the degree of tissue trauma in laparoscopic-assisted and open resections in Crohn's disease, probably because of interference with disease-specific cytokine interactions. In contrast, granulocyte elastase has to be considered a strong marker discriminating the different severity of surgical trauma induced by laparoscopic-assisted vs. open resection in Crohn's disease. |
| doi_str_mv | 10.1007/bf02235052 |
| format | Article |
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Eleven patients in each group (open and laparoscopic-assisted surgery) were matched for indication, surgical procedure, and Crohn's disease activity index. Serum IL-4, IL-6, and IL-10 were measured using enzyme-linked immunosorbent assay. Serum C-reactive protein was determined by immunoturbidimetric assay. Plasma granulocyte elastase was determined by immunoactivation immunoassay. Blood was sampled preoperatively, six hours after the operation, and at postoperative Days 1 to 5.
IL-4 was not detectable in any sample analyzed. Serum IL-6 and IL-10 levels peaked postoperatively in both groups without significant differences between laparoscopic-assisted (185.6 +/-54.1 pg/ml and 112.1 +/- 19.4 pg/ml, respectively; mean +/-standard error of the mean) and open surgery (431.1 +/-240.4 pg/ml and 196.7 +/- 56.5 pg/ml, respectively). Serum C-reactive protein levels also rose postoperatively, with a peak on the second day, but showed similar values after laparoscopic-assisted (107.1 +/- 12.1 mg/l) and open (128.3 +/- 17.5 mg/l) surgery. Plasma granulocyte elastase levels peaked on the first and second postoperative day and were found elevated almost throughout the five-day observation period. Comparison between the groups revealed significantly (P < 0.02) lower values after laparoscopic-assisted (Day 1, 46.5 +/- 8.9 microg/l; Day 2, 41.9 +/- 5.9 microg/l) when compared with open surgery (Day 1, 89.7 +/- 13.8 microg/l; Day 2, 91.4 +/- 14).
Serum IL-6 and IL-10 may not be ideal measures for evaluation of the degree of tissue trauma in laparoscopic-assisted and open resections in Crohn's disease, probably because of interference with disease-specific cytokine interactions. In contrast, granulocyte elastase has to be considered a strong marker discriminating the different severity of surgical trauma induced by laparoscopic-assisted vs. open resection in Crohn's disease.</description><identifier>ISSN: 0012-3706</identifier><identifier>EISSN: 1530-0358</identifier><identifier>DOI: 10.1007/bf02235052</identifier><identifier>PMID: 10566539</identifier><identifier>CODEN: DICRAG</identifier><language>eng</language><publisher>Secaucus, NJ: Springer</publisher><subject>Adult ; Biological and medical sciences ; Biomarkers - blood ; C-Reactive Protein - metabolism ; Crohn Disease - blood ; Crohn Disease - surgery ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Interleukin-10 - metabolism ; Interleukin-4 - metabolism ; Interleukin-6 - metabolism ; Interleukins - metabolism ; Laparoscopy ; Leukocyte Elastase - metabolism ; Male ; Medical sciences ; Nephelometry and Turbidimetry ; Retrospective Studies ; Stomach, duodenum, intestine, rectum, anus ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system</subject><ispartof>Diseases of the colon & rectum, 1999-11, Vol.42 (11), p.1480-1486</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-a3b6cba29f70576e8e38bdce40685a85b30b5857d107765ec5eb831078a9b5953</citedby><cites>FETCH-LOGICAL-c378t-a3b6cba29f70576e8e38bdce40685a85b30b5857d107765ec5eb831078a9b5953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1993956$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10566539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HILDEBRANDT, U</creatorcontrib><creatorcontrib>KESSLER, K</creatorcontrib><creatorcontrib>PISTORIUS, G</creatorcontrib><creatorcontrib>LINDEMANN, W</creatorcontrib><creatorcontrib>ECKER, K. W</creatorcontrib><creatorcontrib>FEIFEL, G</creatorcontrib><creatorcontrib>MENGER, M. D</creatorcontrib><title>Granulocyte elastase and systemic cytokine response after laparoscopic-assisted and open resections in Crohn's disease</title><title>Diseases of the colon & rectum</title><addtitle>Dis Colon Rectum</addtitle><description>The aim of this study was to assess whether systemic proinflammatory cytokines (IL-6), anti-inflammatory cytokines (IL-4, IL-10), acute phase proteins (C-reactive protein), or granulocyte elastase are valuable indicators for determining the degree of surgical trauma after open vs. laparoscopic-assisted resections in Crohn's disease.
Eleven patients in each group (open and laparoscopic-assisted surgery) were matched for indication, surgical procedure, and Crohn's disease activity index. Serum IL-4, IL-6, and IL-10 were measured using enzyme-linked immunosorbent assay. Serum C-reactive protein was determined by immunoturbidimetric assay. Plasma granulocyte elastase was determined by immunoactivation immunoassay. Blood was sampled preoperatively, six hours after the operation, and at postoperative Days 1 to 5.
IL-4 was not detectable in any sample analyzed. Serum IL-6 and IL-10 levels peaked postoperatively in both groups without significant differences between laparoscopic-assisted (185.6 +/-54.1 pg/ml and 112.1 +/- 19.4 pg/ml, respectively; mean +/-standard error of the mean) and open surgery (431.1 +/-240.4 pg/ml and 196.7 +/- 56.5 pg/ml, respectively). Serum C-reactive protein levels also rose postoperatively, with a peak on the second day, but showed similar values after laparoscopic-assisted (107.1 +/- 12.1 mg/l) and open (128.3 +/- 17.5 mg/l) surgery. Plasma granulocyte elastase levels peaked on the first and second postoperative day and were found elevated almost throughout the five-day observation period. Comparison between the groups revealed significantly (P < 0.02) lower values after laparoscopic-assisted (Day 1, 46.5 +/- 8.9 microg/l; Day 2, 41.9 +/- 5.9 microg/l) when compared with open surgery (Day 1, 89.7 +/- 13.8 microg/l; Day 2, 91.4 +/- 14).
Serum IL-6 and IL-10 may not be ideal measures for evaluation of the degree of tissue trauma in laparoscopic-assisted and open resections in Crohn's disease, probably because of interference with disease-specific cytokine interactions. In contrast, granulocyte elastase has to be considered a strong marker discriminating the different severity of surgical trauma induced by laparoscopic-assisted vs. open resection in Crohn's disease.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - metabolism</subject><subject>Crohn Disease - blood</subject><subject>Crohn Disease - surgery</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Humans</subject><subject>Interleukin-10 - metabolism</subject><subject>Interleukin-4 - metabolism</subject><subject>Interleukin-6 - metabolism</subject><subject>Interleukins - metabolism</subject><subject>Laparoscopy</subject><subject>Leukocyte Elastase - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephelometry and Turbidimetry</subject><subject>Retrospective Studies</subject><subject>Stomach, duodenum, intestine, rectum, anus</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><issn>0012-3706</issn><issn>1530-0358</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0E1LJDEQBuAgLjp-XPwBkoO4IPRa3Zl89FGH1V0Q9qLnJklXY7Sn06Z6Fubfm3FG9BSKeqpCvYydlfCrBNDXroOqEhJktcdmpRRQgJBmn80AyqoQGtQhOyJ6ySVUoA_YYQlSKSnqGft_n-yw6qNfT8ixtzRZQm6HltOaJlwGz3MrvoYBeUIa47BpdxMm3tvRpkg-jsEXlihk336MxhGHjUY_hTzAw8AXKT4PP4m3gTD_cMJ-dLYnPN29x-zp7vfj4k_x8O_-7-LmofBCm6mwwinvbFV3GqRWaFAY13qcgzLSGukEOGmkbkvQWkn0Ep0RuTC2drKW4phdbveOKb6tkKZmGchj39sB44oaVVemnKt5hldb6PNJlLBrxhSWNq2bEppNys3t3WfKGZ_vtq7cEttvdBtrBhc7YMnbvssZ-0Bfrq5FLZV4B7kEhdI</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>HILDEBRANDT, U</creator><creator>KESSLER, K</creator><creator>PISTORIUS, G</creator><creator>LINDEMANN, W</creator><creator>ECKER, K. W</creator><creator>FEIFEL, G</creator><creator>MENGER, M. D</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991101</creationdate><title>Granulocyte elastase and systemic cytokine response after laparoscopic-assisted and open resections in Crohn's disease</title><author>HILDEBRANDT, U ; KESSLER, K ; PISTORIUS, G ; LINDEMANN, W ; ECKER, K. W ; FEIFEL, G ; MENGER, M. D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-a3b6cba29f70576e8e38bdce40685a85b30b5857d107765ec5eb831078a9b5953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - metabolism</topic><topic>Crohn Disease - blood</topic><topic>Crohn Disease - surgery</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Humans</topic><topic>Interleukin-10 - metabolism</topic><topic>Interleukin-4 - metabolism</topic><topic>Interleukin-6 - metabolism</topic><topic>Interleukins - metabolism</topic><topic>Laparoscopy</topic><topic>Leukocyte Elastase - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephelometry and Turbidimetry</topic><topic>Retrospective Studies</topic><topic>Stomach, duodenum, intestine, rectum, anus</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HILDEBRANDT, U</creatorcontrib><creatorcontrib>KESSLER, K</creatorcontrib><creatorcontrib>PISTORIUS, G</creatorcontrib><creatorcontrib>LINDEMANN, W</creatorcontrib><creatorcontrib>ECKER, K. W</creatorcontrib><creatorcontrib>FEIFEL, G</creatorcontrib><creatorcontrib>MENGER, M. 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D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Granulocyte elastase and systemic cytokine response after laparoscopic-assisted and open resections in Crohn's disease</atitle><jtitle>Diseases of the colon & rectum</jtitle><addtitle>Dis Colon Rectum</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>42</volume><issue>11</issue><spage>1480</spage><epage>1486</epage><pages>1480-1486</pages><issn>0012-3706</issn><eissn>1530-0358</eissn><coden>DICRAG</coden><abstract>The aim of this study was to assess whether systemic proinflammatory cytokines (IL-6), anti-inflammatory cytokines (IL-4, IL-10), acute phase proteins (C-reactive protein), or granulocyte elastase are valuable indicators for determining the degree of surgical trauma after open vs. laparoscopic-assisted resections in Crohn's disease.
Eleven patients in each group (open and laparoscopic-assisted surgery) were matched for indication, surgical procedure, and Crohn's disease activity index. Serum IL-4, IL-6, and IL-10 were measured using enzyme-linked immunosorbent assay. Serum C-reactive protein was determined by immunoturbidimetric assay. Plasma granulocyte elastase was determined by immunoactivation immunoassay. Blood was sampled preoperatively, six hours after the operation, and at postoperative Days 1 to 5.
IL-4 was not detectable in any sample analyzed. Serum IL-6 and IL-10 levels peaked postoperatively in both groups without significant differences between laparoscopic-assisted (185.6 +/-54.1 pg/ml and 112.1 +/- 19.4 pg/ml, respectively; mean +/-standard error of the mean) and open surgery (431.1 +/-240.4 pg/ml and 196.7 +/- 56.5 pg/ml, respectively). Serum C-reactive protein levels also rose postoperatively, with a peak on the second day, but showed similar values after laparoscopic-assisted (107.1 +/- 12.1 mg/l) and open (128.3 +/- 17.5 mg/l) surgery. Plasma granulocyte elastase levels peaked on the first and second postoperative day and were found elevated almost throughout the five-day observation period. Comparison between the groups revealed significantly (P < 0.02) lower values after laparoscopic-assisted (Day 1, 46.5 +/- 8.9 microg/l; Day 2, 41.9 +/- 5.9 microg/l) when compared with open surgery (Day 1, 89.7 +/- 13.8 microg/l; Day 2, 91.4 +/- 14).
Serum IL-6 and IL-10 may not be ideal measures for evaluation of the degree of tissue trauma in laparoscopic-assisted and open resections in Crohn's disease, probably because of interference with disease-specific cytokine interactions. In contrast, granulocyte elastase has to be considered a strong marker discriminating the different severity of surgical trauma induced by laparoscopic-assisted vs. open resection in Crohn's disease.</abstract><cop>Secaucus, NJ</cop><pub>Springer</pub><pmid>10566539</pmid><doi>10.1007/bf02235052</doi><tpages>7</tpages></addata></record> |
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| ispartof | Diseases of the colon & rectum, 1999-11, Vol.42 (11), p.1480-1486 |
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| subjects | Adult Biological and medical sciences Biomarkers - blood C-Reactive Protein - metabolism Crohn Disease - blood Crohn Disease - surgery Enzyme-Linked Immunosorbent Assay Female Humans Interleukin-10 - metabolism Interleukin-4 - metabolism Interleukin-6 - metabolism Interleukins - metabolism Laparoscopy Leukocyte Elastase - metabolism Male Medical sciences Nephelometry and Turbidimetry Retrospective Studies Stomach, duodenum, intestine, rectum, anus Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system |
| title | Granulocyte elastase and systemic cytokine response after laparoscopic-assisted and open resections in Crohn's disease |
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