Quantitative analysis of formyl peptide receptor coupling to g(i)alpha(1), g(i)alpha(2), and g(i)alpha(3)

The human formyl peptide receptor (FPR) is a prototypical G(i) protein-coupled receptor, but little is known about quantitative aspects of FPR-G(i) protein coupling. To address this issue, we fused the FPR to G(i)alpha(1), G(i)alpha(2), and G(i)alpha(3) and expressed the fusion proteins in Sf9 insec...

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Veröffentlicht in:	The Journal of biological chemistry 1999-11, Vol.274 (47), p.33259-33266
Hauptverfasser:	Wenzel-Seifert, K, Arthur, J M, Liu, H Y, Seifert, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals GTP-Binding Protein alpha Subunits, Gi-Go - metabolism Guanosine 5'-O-(3-Thiotriphosphate) - metabolism Humans Kinetics N-Formylmethionine Leucyl-Phenylalanine - metabolism Protein Binding Receptors, Formyl Peptide Receptors, Immunologic - metabolism Receptors, Peptide - metabolism Recombinant Fusion Proteins - metabolism Spodoptera
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