Analysis of Volatile Organic Compounds in the Exhaled Breath for the Diagnosis of Lung Cancer
Volatile organic compounds are able to be detected in the exhaled breath by a variety of sensing techniques. These volatiles may be produced by cellular metabolic processes, or inhaled/absorbed from exogenous sources. Lung cancer cells may produce and process these compounds different than normal ce...
Gespeichert in:
| Veröffentlicht in: | Journal of thoracic oncology 2008-07, Vol.3 (7), p.774-780 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 780 |
|---|---|
| container_issue | 7 |
| container_start_page | 774 |
| container_title | Journal of thoracic oncology |
| container_volume | 3 |
| creator | Mazzone, Peter J. |
| description | Volatile organic compounds are able to be detected in the exhaled breath by a variety of sensing techniques. These volatiles may be produced by cellular metabolic processes, or inhaled/absorbed from exogenous sources. Lung cancer cells may produce and process these compounds different than normal cells. The differences may be detectable in the breath. The following manuscript will review the evidence supporting the premise that a unique chemical signature can be detected in the breath of patients with lung cancer, discuss the results of studies using mass spectrometry and nonspecific chemical sensing techniques to detect the unique lung cancer signature, and speculate on the advancements that must occur to develop a breath test accurate enough to be clinically useful. |
| doi_str_mv | 10.1097/JTO.0b013e31817c7439 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69279224</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1556086415333529</els_id><sourcerecordid>69279224</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5174-ae6fff30c968bfd96251d67bc4c87d435e5975e2c7ffe4ca18d093229eef7c2a3</originalsourceid><addsrcrecordid>eNp9kEFv1DAQhSMEoqXwDxDyiVvK2LFj-4JUtqUFrbSXwg1ZXme8MXjjxU4o_fekbKRKHDiMZjSa9-bpq6rXFM4paPnu8-3mHLZAG2yootJJ3ugn1SkVoq1po-DpMoNq-Un1opTvAFwAV8-rE6qE5g0Tp9W3i8HG-xIKSZ58TdGOISLZ5J0dgiOrtD-kaegKCQMZeyRXv3sbsSMfMtqxJz7lv-vLYHdDWlzW07AjKzs4zC-rZ97Ggq-WflZ9-Xh1u7qp15vrT6uLde0Elby22HrvG3C6VVvf6ZYJ2rVy67hTsuONQKGlQOak98idpaoD3TCmEb10zDZn1duj7yGnnxOW0exDcRijHTBNxbSaSc0Ynw_58dDlVEpGbw457G2-NxTMA1YzYzX_Yp1lbxb_abvH7lG0cHz0vUtxxFx-xOkOs-nRxrE3QOfXSvOaASiQAFDPRR_ivD_KcIbzK8yK4gLO5LqQ0Y2mS-H_wf4A99SYNA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69279224</pqid></control><display><type>article</type><title>Analysis of Volatile Organic Compounds in the Exhaled Breath for the Diagnosis of Lung Cancer</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>Mazzone, Peter J.</creator><creatorcontrib>Mazzone, Peter J.</creatorcontrib><description>Volatile organic compounds are able to be detected in the exhaled breath by a variety of sensing techniques. These volatiles may be produced by cellular metabolic processes, or inhaled/absorbed from exogenous sources. Lung cancer cells may produce and process these compounds different than normal cells. The differences may be detectable in the breath. The following manuscript will review the evidence supporting the premise that a unique chemical signature can be detected in the breath of patients with lung cancer, discuss the results of studies using mass spectrometry and nonspecific chemical sensing techniques to detect the unique lung cancer signature, and speculate on the advancements that must occur to develop a breath test accurate enough to be clinically useful.</description><identifier>ISSN: 1556-0864</identifier><identifier>EISSN: 1556-1380</identifier><identifier>DOI: 10.1097/JTO.0b013e31817c7439</identifier><identifier>PMID: 18594325</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Biosensing Techniques ; Breath test ; Breath Tests ; Diagnostic test ; Gas Chromatography-Mass Spectrometry ; Humans ; Lung Neoplasms - diagnosis ; Mass spectrometry ; Organic Chemicals - analysis ; Sensitivity and Specificity ; Volatile organic compounds ; Volatilization</subject><ispartof>Journal of thoracic oncology, 2008-07, Vol.3 (7), p.774-780</ispartof><rights>2008 International Association for the Study of Lung Cancer</rights><rights>2008International Association for the Study of Lung Cancer</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5174-ae6fff30c968bfd96251d67bc4c87d435e5975e2c7ffe4ca18d093229eef7c2a3</citedby><cites>FETCH-LOGICAL-c5174-ae6fff30c968bfd96251d67bc4c87d435e5975e2c7ffe4ca18d093229eef7c2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18594325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mazzone, Peter J.</creatorcontrib><title>Analysis of Volatile Organic Compounds in the Exhaled Breath for the Diagnosis of Lung Cancer</title><title>Journal of thoracic oncology</title><addtitle>J Thorac Oncol</addtitle><description>Volatile organic compounds are able to be detected in the exhaled breath by a variety of sensing techniques. These volatiles may be produced by cellular metabolic processes, or inhaled/absorbed from exogenous sources. Lung cancer cells may produce and process these compounds different than normal cells. The differences may be detectable in the breath. The following manuscript will review the evidence supporting the premise that a unique chemical signature can be detected in the breath of patients with lung cancer, discuss the results of studies using mass spectrometry and nonspecific chemical sensing techniques to detect the unique lung cancer signature, and speculate on the advancements that must occur to develop a breath test accurate enough to be clinically useful.</description><subject>Biosensing Techniques</subject><subject>Breath test</subject><subject>Breath Tests</subject><subject>Diagnostic test</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Humans</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Mass spectrometry</subject><subject>Organic Chemicals - analysis</subject><subject>Sensitivity and Specificity</subject><subject>Volatile organic compounds</subject><subject>Volatilization</subject><issn>1556-0864</issn><issn>1556-1380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFv1DAQhSMEoqXwDxDyiVvK2LFj-4JUtqUFrbSXwg1ZXme8MXjjxU4o_fekbKRKHDiMZjSa9-bpq6rXFM4paPnu8-3mHLZAG2yootJJ3ugn1SkVoq1po-DpMoNq-Un1opTvAFwAV8-rE6qE5g0Tp9W3i8HG-xIKSZ58TdGOISLZ5J0dgiOrtD-kaegKCQMZeyRXv3sbsSMfMtqxJz7lv-vLYHdDWlzW07AjKzs4zC-rZ97Ggq-WflZ9-Xh1u7qp15vrT6uLde0Elby22HrvG3C6VVvf6ZYJ2rVy67hTsuONQKGlQOak98idpaoD3TCmEb10zDZn1duj7yGnnxOW0exDcRijHTBNxbSaSc0Ynw_58dDlVEpGbw457G2-NxTMA1YzYzX_Yp1lbxb_abvH7lG0cHz0vUtxxFx-xOkOs-nRxrE3QOfXSvOaASiQAFDPRR_ivD_KcIbzK8yK4gLO5LqQ0Y2mS-H_wf4A99SYNA</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Mazzone, Peter J.</creator><general>Elsevier Inc</general><general>International Association for the Study of Lung Cancer</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200807</creationdate><title>Analysis of Volatile Organic Compounds in the Exhaled Breath for the Diagnosis of Lung Cancer</title><author>Mazzone, Peter J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5174-ae6fff30c968bfd96251d67bc4c87d435e5975e2c7ffe4ca18d093229eef7c2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biosensing Techniques</topic><topic>Breath test</topic><topic>Breath Tests</topic><topic>Diagnostic test</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>Humans</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Mass spectrometry</topic><topic>Organic Chemicals - analysis</topic><topic>Sensitivity and Specificity</topic><topic>Volatile organic compounds</topic><topic>Volatilization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mazzone, Peter J.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of thoracic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mazzone, Peter J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of Volatile Organic Compounds in the Exhaled Breath for the Diagnosis of Lung Cancer</atitle><jtitle>Journal of thoracic oncology</jtitle><addtitle>J Thorac Oncol</addtitle><date>2008-07</date><risdate>2008</risdate><volume>3</volume><issue>7</issue><spage>774</spage><epage>780</epage><pages>774-780</pages><issn>1556-0864</issn><eissn>1556-1380</eissn><abstract>Volatile organic compounds are able to be detected in the exhaled breath by a variety of sensing techniques. These volatiles may be produced by cellular metabolic processes, or inhaled/absorbed from exogenous sources. Lung cancer cells may produce and process these compounds different than normal cells. The differences may be detectable in the breath. The following manuscript will review the evidence supporting the premise that a unique chemical signature can be detected in the breath of patients with lung cancer, discuss the results of studies using mass spectrometry and nonspecific chemical sensing techniques to detect the unique lung cancer signature, and speculate on the advancements that must occur to develop a breath test accurate enough to be clinically useful.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18594325</pmid><doi>10.1097/JTO.0b013e31817c7439</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1556-0864 |
| ispartof | Journal of thoracic oncology, 2008-07, Vol.3 (7), p.774-780 |
| issn | 1556-0864 1556-1380 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69279224 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Biosensing Techniques Breath test Breath Tests Diagnostic test Gas Chromatography-Mass Spectrometry Humans Lung Neoplasms - diagnosis Mass spectrometry Organic Chemicals - analysis Sensitivity and Specificity Volatile organic compounds Volatilization |
| title | Analysis of Volatile Organic Compounds in the Exhaled Breath for the Diagnosis of Lung Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T05%3A16%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Analysis%20of%20Volatile%20Organic%20Compounds%20in%20the%20Exhaled%20Breath%20for%20the%20Diagnosis%20of%20Lung%20Cancer&rft.jtitle=Journal%20of%20thoracic%20oncology&rft.au=Mazzone,%20Peter%20J.&rft.date=2008-07&rft.volume=3&rft.issue=7&rft.spage=774&rft.epage=780&rft.pages=774-780&rft.issn=1556-0864&rft.eissn=1556-1380&rft_id=info:doi/10.1097/JTO.0b013e31817c7439&rft_dat=%3Cproquest_cross%3E69279224%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69279224&rft_id=info:pmid/18594325&rft_els_id=S1556086415333529&rfr_iscdi=true |