Flow-batch technique for the simultaneous enzymatic determination of levodopa and carbidopa in pharmaceuticals using PLS and successive projections algorithm

An enzymatic flow-batch system with spectrophotometric detection was developed for simultaneous determination of levodopa [( S)-2 amino-3-(3,4-dihydroxyphenyl)propionic acid] and carbidopa [( S)-3-(3,4-dihydroxyphenyl)-2-hydrazino-2-methylpropionic acid] in pharmaceutical preparations. The data were...

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Veröffentlicht in:	Talanta (Oxford) 2008-05, Vol.75 (4), p.950-958
Hauptverfasser:	Grünhut, Marcos, Centurión, María E., Fragoso, Wallace D., Almeida, Luciano F., de Araújo, Mário C.U., Band, Beatriz S. Fernández
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Analytical chemistry Buffers Carbidopa Carbidopa - analysis Carbidopa - chemistry Catechol Oxidase - chemistry Catechol Oxidase - metabolism Chemistry Chromatographic methods and physical methods associated with chromatography Computer Simulation Exact sciences and technology Flow-batch Ipomoea batatas - enzymology Least-Squares Analysis Levodopa Levodopa - analysis Levodopa - chemistry Linear Models MLR-SPA Other chromatographic methods Oxidation-Reduction Pharmaceutical Preparations - chemistry Phosphates - chemistry PLS Polyphenol oxidase Spectrometric and optical methods Spectrophotometry - methods Time Factors
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