A randomized clinical trial of alpha(1)-antitrypsin augmentation therapy

We have investigated whether restoration of the balance between neutrophil elastase and its inhibitor, alpha(1)-antitrypsin, can prevent the progression of pulmonary emphysema in patients with alpha(1)-antitrypsin deficiency. Twenty-six Danish and 30 Dutch ex-smokers with alpha(1)-antitrypsin defici...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 1999-11, Vol.160 (5 Pt 1), p.1468-1472
Hauptverfasser:	Dirksen, A, Dijkman, J H, Madsen, F, Stoel, B, Hutchison, D C, Ulrik, C S, Skovgaard, L T, Kok-Jensen, A, Rudolphus, A, Seersholm, N, Vrooman, H A, Reiber, J H, Hansen, N C, Heckscher, T, Viskum, K, Stolk, J
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha 1-Antitrypsin - therapeutic use alpha 1-Antitrypsin Deficiency - complications alpha 1-Antitrypsin Deficiency - drug therapy Double-Blind Method Female Forced Expiratory Volume Humans Lung - diagnostic imaging Male Middle Aged Phenotype Pulmonary Diffusing Capacity Pulmonary Emphysema - diagnostic imaging Pulmonary Emphysema - drug therapy Pulmonary Emphysema - etiology Pulmonary Emphysema - physiopathology Spirometry Tomography, X-Ray Computed Vital Capacity
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