Sexual Transmission and Propagation of SIV and HIV in Resting and Activated CD4$^+$ T Cells

In sexual transmission of simian immunodeficiency virus, and early and later stages of human immunodeficiency virus-type 1 (HIV-1) infection, both viruses were found to replicate predominantly in CD4$^+$ T cells at the portal of entry and in lymphoid tissues. Infection was propagated not only in act...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1999-11, Vol.286 (5443), p.1353-1357
Hauptverfasser:	Z.-Q. Zhang, Schuler, T., Zupancic, M., Wietgrefe, S., Staskus, K. A., Reimann, K. A., Reinhart, T. A., Rogan, M., Cavert, W., Miller, C. J., Veazey, R. S., Notermans, D., Little, S., Danner, S. A., Richman, D. D., Havlir, D., Wong, J., Jordan, H. L., Schacker, T. W., Racz, P., Tenner-Racz, K., Letvin, N. L., Wolinsky, S., Haase, A. T.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Anti-HIV Agents - therapeutic use Antibodies Biological and medical sciences CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology Cell Cycle Cell growth Cell lines Cervix Uteri - virology Epithelial Cells - virology Female Highly active antiretroviral therapy HIV 1 HIV Infections - drug therapy HIV Infections - transmission HIV Infections - virology HIV-1 - physiology Human viral diseases Infections Infectious diseases Lymph Nodes - virology Lymphocyte Activation Macaca mulatta Medical sciences RNA RNA, Viral - analysis Simian Acquired Immunodeficiency Syndrome - transmission Simian Acquired Immunodeficiency Syndrome - virology Simian Immunodeficiency Virus - physiology T lymphocytes Time Factors Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virus Replication Viruses
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