The Receptor-Mediated Uptake, Survival, Replication, and Drug Sensitivity of Mycobacterium tuberculosis within the Macrophage-like Cell Line THP-1: A Comparison with Human Monocyte-Derived Macrophages

We have compared the interaction of Mycobacterium tuberculosis with the human macrophage-like cell line THP-1 and with human monocyte-derived macrophages (MDM). The association of M. tuberculosis with THP-1 and MDM was comparable in both the presence and the absence of serum. For both cells, serum-m...

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Veröffentlicht in:	Cellular immunology 1999-10, Vol.197 (1), p.1-9
Hauptverfasser:	Stokes, Richard W., Doxsee, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies - pharmacology Antitubercular Agents - pharmacology Bacterial Adhesion - drug effects Bacterial Adhesion - immunology Cell Line Glucans - immunology Glucans - metabolism Humans Isoniazid - pharmacology Macrophage-1 Antigen - immunology Macrophages - metabolism Macrophages - microbiology Mannans - immunology Microbial Sensitivity Tests Monocytes - metabolism Monocytes - microbiology Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - immunology Polysaccharides - metabolism Receptors, Complement 3b - biosynthesis Receptors, Fc - biosynthesis Receptors, Mitogen - biosynthesis THP-1 cells Zymosan - metabolism
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