Mechanism of antinociceptive action of clonidine in nonmyelinated nerve fibres

Despite a large body of clinical evidence in favour of a local anesthetic effect of clonidine, the underlying mechanism has not yet been elucidated. In this study we have used the sucrose-gap method to measure the effects of clonidine on the electrophysiological properties of nonmyelinated nerve fib...

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Veröffentlicht in:	European journal of pharmacology 1999-10, Vol.383 (1), p.1-8
Hauptverfasser:	Erne-Brand, Françoise, Jirounek, Petr, Drewe, Jürgen, Hampl, Karl, Schneider, Markus C
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Adrenergic alpha-Antagonists - pharmacology Afterpotential Analgesics - pharmacology Anesthetics, Local - pharmacology Anesthetics. Neuromuscular blocking agents Animals Antinociception Biological and medical sciences C-fibre Clonidine Clonidine - pharmacology Electric Stimulation Electrophysiology In Vitro Techniques Medical sciences Myelin Sheath - physiology Nerve Fibers - drug effects Nerve Fibers - physiology Neuropharmacology Pharmacology. Drug treatments Rabbits Receptors, Adrenergic, alpha-2 - drug effects Receptors, Adrenergic, alpha-2 - physiology Sodium Channels - drug effects Sucrose-gap Time Factors Vagus Nerve - drug effects Vagus Nerve - ultrastructure Yohimbine - pharmacology
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