Galphas-coupled receptor signaling actively down-regulates alpha4beta1-integrin affinity: a possible mechanism for cell de-adhesion

Activation of integrins in response to inside-out signaling serves as a basis for leukocyte arrest on endothelium, and migration of immune cells. Integrin-dependent adhesion is controlled by the conformational state of the molecule (i.e. change in the affinity for the ligand and molecular unbending...

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Veröffentlicht in:	BMC immunology 2008-06, Vol.9, p.26-26
Hauptverfasser:	Chigaev, Alexandre, Waller, Anna, Amit, Or, Sklar, Larry A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Agonists - pharmacology Cell Adhesion - drug effects Cell Adhesion - immunology Chemokine CXCL12 - agonists Chemokine CXCL12 - pharmacology Down-Regulation Histamine Agonists - pharmacology Humans Integrin alpha4beta1 - chemistry Integrin alpha4beta1 - immunology Integrin alpha4beta1 - metabolism Isoproterenol - pharmacology Leukocytes, Mononuclear Oligopeptides - pharmacology Phenylurea Compounds - pharmacology Protein Binding - drug effects Protein Conformation Receptor Cross-Talk - immunology Receptors, Adrenergic, beta-2 - immunology Receptors, Adrenergic, beta-2 - metabolism Receptors, CXCR4 - agonists Receptors, Histamine H2 - immunology Receptors, Histamine H2 - metabolism Recombinant Proteins - agonists Signal Transduction Thiazoles - pharmacology U937 Cells
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