Expression of secretory leukocyte protease inhibitor in women with endometriosis
Objective: To explore endometriosis-related molecules in patients with use of differential display analysis. Design: Prospective study. Setting: Nagoya City University Medical School, Nagoya, Japan. Patient(s): Women with endometriosis (n = 27) and without endometriosis (n = 21). Intervention(s): Su...
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| Veröffentlicht in: | Fertility and sterility 1999-11, Vol.72 (5), p.857-867 |
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| container_title | Fertility and sterility |
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| creator | Suzumori, Nobuhiro Sato, Makoto Yoneda, Takunari Ozaki, Yasuhiko Takagi, Hiroshi Suzumori, Kaoru |
| description | Objective: To explore endometriosis-related molecules in patients with use of differential display analysis.
Design: Prospective study.
Setting: Nagoya City University Medical School, Nagoya, Japan.
Patient(s): Women with endometriosis (n = 27) and without endometriosis (n = 21).
Intervention(s): Surgery was scheduled in the proliferative or secretory phase of the menstrual cycle.
Main Outcome Measure(s): Differentially expressed products of endometrioma samples were sequenced at nucleotides. One of the candidate genes, secretory leukocyte protease inhibitor (SLPI) gene, was analyzed with use of in situ hybridization and Northern blot analyses. Distribution of SLPI was determined by immunohistochemistry, and the amount of SLPI in the peritoneal fluid and serum was measured by ELISA.
Result(s): Distinct expression of SLPI messenger RNA could be detected in the endometrial-type epithelium of extrauterine endometriotic tissues and in the eutopic endometrium of women with endometriosis. SLPI was localized in the endometrial-type epithelium of endometriomas immunohistochemically. The amount of SLPI in the peritoneal fluid was markedly elevated in the endometriosis group (91.6 ± 6.6 ng/mL compared with 68.4 ± 5.3 ng/mL in the controls).
Conclusion(s): Secretory leukocyte protease inhibitor may be involved in the pathogenesis of endometriosis. |
| doi_str_mv | 10.1016/S0015-0282(99)00381-7 |
| format | Article |
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Design: Prospective study.
Setting: Nagoya City University Medical School, Nagoya, Japan.
Patient(s): Women with endometriosis (n = 27) and without endometriosis (n = 21).
Intervention(s): Surgery was scheduled in the proliferative or secretory phase of the menstrual cycle.
Main Outcome Measure(s): Differentially expressed products of endometrioma samples were sequenced at nucleotides. One of the candidate genes, secretory leukocyte protease inhibitor (SLPI) gene, was analyzed with use of in situ hybridization and Northern blot analyses. Distribution of SLPI was determined by immunohistochemistry, and the amount of SLPI in the peritoneal fluid and serum was measured by ELISA.
Result(s): Distinct expression of SLPI messenger RNA could be detected in the endometrial-type epithelium of extrauterine endometriotic tissues and in the eutopic endometrium of women with endometriosis. SLPI was localized in the endometrial-type epithelium of endometriomas immunohistochemically. The amount of SLPI in the peritoneal fluid was markedly elevated in the endometriosis group (91.6 ± 6.6 ng/mL compared with 68.4 ± 5.3 ng/mL in the controls).
Conclusion(s): Secretory leukocyte protease inhibitor may be involved in the pathogenesis of endometriosis.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(99)00381-7</identifier><identifier>PMID: 10560990</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Ascitic Fluid - metabolism ; Biological and medical sciences ; Blotting, Northern ; Case-Control Studies ; Differential display ; endometriosis ; Endometriosis - metabolism ; Female genital diseases ; Gene Expression Regulation, Enzymologic - physiology ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; In Situ Hybridization ; Medical sciences ; Middle Aged ; Non tumoral diseases ; peritoneal fluid ; Proteinase Inhibitory Proteins, Secretory ; Proteins - genetics ; retrograde implantation ; Reverse Transcriptase Polymerase Chain Reaction ; Secretory Leukocyte Peptidase Inhibitor ; secretory leukocyte protease inhibitor (SLPI) ; Serine Proteinase Inhibitors - genetics</subject><ispartof>Fertility and sterility, 1999-11, Vol.72 (5), p.857-867</ispartof><rights>1999 American Society for Reproductive Medicine</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-4b38c1c8f27a591a8764b810888d46842e6887431353ca166a6feb998a64c8c83</citedby><cites>FETCH-LOGICAL-c437t-4b38c1c8f27a591a8764b810888d46842e6887431353ca166a6feb998a64c8c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0015-0282(99)00381-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1239473$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10560990$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suzumori, Nobuhiro</creatorcontrib><creatorcontrib>Sato, Makoto</creatorcontrib><creatorcontrib>Yoneda, Takunari</creatorcontrib><creatorcontrib>Ozaki, Yasuhiko</creatorcontrib><creatorcontrib>Takagi, Hiroshi</creatorcontrib><creatorcontrib>Suzumori, Kaoru</creatorcontrib><title>Expression of secretory leukocyte protease inhibitor in women with endometriosis</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective: To explore endometriosis-related molecules in patients with use of differential display analysis.
Design: Prospective study.
Setting: Nagoya City University Medical School, Nagoya, Japan.
Patient(s): Women with endometriosis (n = 27) and without endometriosis (n = 21).
Intervention(s): Surgery was scheduled in the proliferative or secretory phase of the menstrual cycle.
Main Outcome Measure(s): Differentially expressed products of endometrioma samples were sequenced at nucleotides. One of the candidate genes, secretory leukocyte protease inhibitor (SLPI) gene, was analyzed with use of in situ hybridization and Northern blot analyses. Distribution of SLPI was determined by immunohistochemistry, and the amount of SLPI in the peritoneal fluid and serum was measured by ELISA.
Result(s): Distinct expression of SLPI messenger RNA could be detected in the endometrial-type epithelium of extrauterine endometriotic tissues and in the eutopic endometrium of women with endometriosis. SLPI was localized in the endometrial-type epithelium of endometriomas immunohistochemically. The amount of SLPI in the peritoneal fluid was markedly elevated in the endometriosis group (91.6 ± 6.6 ng/mL compared with 68.4 ± 5.3 ng/mL in the controls).
Conclusion(s): Secretory leukocyte protease inhibitor may be involved in the pathogenesis of endometriosis.</description><subject>Adult</subject><subject>Ascitic Fluid - metabolism</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Case-Control Studies</subject><subject>Differential display</subject><subject>endometriosis</subject><subject>Endometriosis - metabolism</subject><subject>Female genital diseases</subject><subject>Gene Expression Regulation, Enzymologic - physiology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases</subject><subject>peritoneal fluid</subject><subject>Proteinase Inhibitory Proteins, Secretory</subject><subject>Proteins - genetics</subject><subject>retrograde implantation</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Secretory Leukocyte Peptidase Inhibitor</subject><subject>secretory leukocyte protease inhibitor (SLPI)</subject><subject>Serine Proteinase Inhibitors - genetics</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhi1UBFvoT6DKoaraQ4odx18nVK2WDwmJStCz5TgT4TYbbz1JYf89XnYF3Lh4bM0z41cPISeM_mCUydNbSpkoaaWrb8Z8p5RrVqo9MmNCyFJIwT-Q2QtySD4i_qGUSqaqA3LIqJDUGDojvxaPqwSIIQ5F7AoEn2CMaV30MP2Nfj1CsUpxBIdQhOE-NCF38614iEvIZxjvCxja_BhTiBjwmOx3rkf4tKtH5Pf54m5-WV7fXFzNf16XvuZqLOuGa8-87irlhGFOK1k3mlGtdVtLXVcgtVY1Z1xw75iUTnbQGKOdrL32mh-Rr9u9Od6_CXC0y4Ae-t4NECe00lSqkmYDii3oU0RM0NlVCkuX1pZRu1Fpn1XajSdrjH1WaVWe-7z7YGqW0L6Z2rrLwJcd4NC7vktu8AFfuYqbWvGMnW0xyDb-B0gWfYDBQxsS-NG2MbyT5Al495An</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>Suzumori, Nobuhiro</creator><creator>Sato, Makoto</creator><creator>Yoneda, Takunari</creator><creator>Ozaki, Yasuhiko</creator><creator>Takagi, Hiroshi</creator><creator>Suzumori, Kaoru</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991101</creationdate><title>Expression of secretory leukocyte protease inhibitor in women with endometriosis</title><author>Suzumori, Nobuhiro ; Sato, Makoto ; Yoneda, Takunari ; Ozaki, Yasuhiko ; Takagi, Hiroshi ; Suzumori, Kaoru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-4b38c1c8f27a591a8764b810888d46842e6887431353ca166a6feb998a64c8c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Ascitic Fluid - metabolism</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Case-Control Studies</topic><topic>Differential display</topic><topic>endometriosis</topic><topic>Endometriosis - metabolism</topic><topic>Female genital diseases</topic><topic>Gene Expression Regulation, Enzymologic - physiology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases</topic><topic>peritoneal fluid</topic><topic>Proteinase Inhibitory Proteins, Secretory</topic><topic>Proteins - genetics</topic><topic>retrograde implantation</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Secretory Leukocyte Peptidase Inhibitor</topic><topic>secretory leukocyte protease inhibitor (SLPI)</topic><topic>Serine Proteinase Inhibitors - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suzumori, Nobuhiro</creatorcontrib><creatorcontrib>Sato, Makoto</creatorcontrib><creatorcontrib>Yoneda, Takunari</creatorcontrib><creatorcontrib>Ozaki, Yasuhiko</creatorcontrib><creatorcontrib>Takagi, Hiroshi</creatorcontrib><creatorcontrib>Suzumori, Kaoru</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suzumori, Nobuhiro</au><au>Sato, Makoto</au><au>Yoneda, Takunari</au><au>Ozaki, Yasuhiko</au><au>Takagi, Hiroshi</au><au>Suzumori, Kaoru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of secretory leukocyte protease inhibitor in women with endometriosis</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>72</volume><issue>5</issue><spage>857</spage><epage>867</epage><pages>857-867</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective: To explore endometriosis-related molecules in patients with use of differential display analysis.
Design: Prospective study.
Setting: Nagoya City University Medical School, Nagoya, Japan.
Patient(s): Women with endometriosis (n = 27) and without endometriosis (n = 21).
Intervention(s): Surgery was scheduled in the proliferative or secretory phase of the menstrual cycle.
Main Outcome Measure(s): Differentially expressed products of endometrioma samples were sequenced at nucleotides. One of the candidate genes, secretory leukocyte protease inhibitor (SLPI) gene, was analyzed with use of in situ hybridization and Northern blot analyses. Distribution of SLPI was determined by immunohistochemistry, and the amount of SLPI in the peritoneal fluid and serum was measured by ELISA.
Result(s): Distinct expression of SLPI messenger RNA could be detected in the endometrial-type epithelium of extrauterine endometriotic tissues and in the eutopic endometrium of women with endometriosis. SLPI was localized in the endometrial-type epithelium of endometriomas immunohistochemically. The amount of SLPI in the peritoneal fluid was markedly elevated in the endometriosis group (91.6 ± 6.6 ng/mL compared with 68.4 ± 5.3 ng/mL in the controls).
Conclusion(s): Secretory leukocyte protease inhibitor may be involved in the pathogenesis of endometriosis.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10560990</pmid><doi>10.1016/S0015-0282(99)00381-7</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Ascitic Fluid - metabolism Biological and medical sciences Blotting, Northern Case-Control Studies Differential display endometriosis Endometriosis - metabolism Female genital diseases Gene Expression Regulation, Enzymologic - physiology Gynecology. Andrology. Obstetrics Humans Immunohistochemistry In Situ Hybridization Medical sciences Middle Aged Non tumoral diseases peritoneal fluid Proteinase Inhibitory Proteins, Secretory Proteins - genetics retrograde implantation Reverse Transcriptase Polymerase Chain Reaction Secretory Leukocyte Peptidase Inhibitor secretory leukocyte protease inhibitor (SLPI) Serine Proteinase Inhibitors - genetics |
| title | Expression of secretory leukocyte protease inhibitor in women with endometriosis |
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