Juvenile Parkinson's disease with REM sleep behavior disorder, sleepiness, and daytime REM onset
We describe an unmedicated patient with juvenile PD with difficulties maintaining wakefulness and the atonia of REM sleep. Laboratory testing showed enhanced muscle activity in REM sleep consistent with a history of dream enactment behavior (i.e., REM sleep behavior disorder) and daytime sleepiness,...
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| Veröffentlicht in: | Neurology 1999-11, Vol.53 (8), p.1868-1870 |
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| container_end_page | 1870 |
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| container_issue | 8 |
| container_start_page | 1868 |
| container_title | Neurology |
| container_volume | 53 |
| creator | RYE, D. B JOHNSTON, L. H WATTS, R. L BLIWISE, D. L |
| description | We describe an unmedicated patient with juvenile PD with difficulties maintaining wakefulness and the atonia of REM sleep. Laboratory testing showed enhanced muscle activity in REM sleep consistent with a history of dream enactment behavior (i.e., REM sleep behavior disorder) and daytime sleepiness, and REM-sleep onsets on multiple sleep latency testing. The results emphasize the potential role of dopamine and basal ganglia circuits in the modulation of activated behavioral states (e.g., wakefulness and REM sleep). |
| doi_str_mv | 10.1212/WNL.53.8.1868 |
| format | Article |
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B ; JOHNSTON, L. H ; WATTS, R. L ; BLIWISE, D. L</creator><creatorcontrib>RYE, D. B ; JOHNSTON, L. H ; WATTS, R. L ; BLIWISE, D. L</creatorcontrib><description>We describe an unmedicated patient with juvenile PD with difficulties maintaining wakefulness and the atonia of REM sleep. Laboratory testing showed enhanced muscle activity in REM sleep consistent with a history of dream enactment behavior (i.e., REM sleep behavior disorder) and daytime sleepiness, and REM-sleep onsets on multiple sleep latency testing. The results emphasize the potential role of dopamine and basal ganglia circuits in the modulation of activated behavioral states (e.g., wakefulness and REM sleep).</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/WNL.53.8.1868</identifier><identifier>PMID: 10563644</identifier><identifier>CODEN: NEURAI</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Adolescent Behavior ; Biological and medical sciences ; Circadian Rhythm ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Diagnosis, Differential ; Diseases in Twins ; Electromyography ; Female ; Genotype ; Humans ; Medical sciences ; Narcolepsy - diagnosis ; Narcolepsy - genetics ; Neurology ; Parkinson Disease - physiopathology ; Parkinson Disease - psychology ; REM Sleep Behavior Disorder - diagnosis ; REM Sleep Behavior Disorder - etiology ; Sleep Stages ; Sleep, REM</subject><ispartof>Neurology, 1999-11, Vol.53 (8), p.1868-1870</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c318t-dfe2d20cba78d437600ebd58463b6dd3f4e7ffc469bdaaba131ab0b3f6dbeb243</citedby><cites>FETCH-LOGICAL-c318t-dfe2d20cba78d437600ebd58463b6dd3f4e7ffc469bdaaba131ab0b3f6dbeb243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1183660$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10563644$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RYE, D. B</creatorcontrib><creatorcontrib>JOHNSTON, L. H</creatorcontrib><creatorcontrib>WATTS, R. L</creatorcontrib><creatorcontrib>BLIWISE, D. L</creatorcontrib><title>Juvenile Parkinson's disease with REM sleep behavior disorder, sleepiness, and daytime REM onset</title><title>Neurology</title><addtitle>Neurology</addtitle><description>We describe an unmedicated patient with juvenile PD with difficulties maintaining wakefulness and the atonia of REM sleep. Laboratory testing showed enhanced muscle activity in REM sleep consistent with a history of dream enactment behavior (i.e., REM sleep behavior disorder) and daytime sleepiness, and REM-sleep onsets on multiple sleep latency testing. The results emphasize the potential role of dopamine and basal ganglia circuits in the modulation of activated behavioral states (e.g., wakefulness and REM sleep).</description><subject>Adolescent</subject><subject>Adolescent Behavior</subject><subject>Biological and medical sciences</subject><subject>Circadian Rhythm</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Diagnosis, Differential</subject><subject>Diseases in Twins</subject><subject>Electromyography</subject><subject>Female</subject><subject>Genotype</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Narcolepsy - diagnosis</subject><subject>Narcolepsy - genetics</subject><subject>Neurology</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson Disease - psychology</subject><subject>REM Sleep Behavior Disorder - diagnosis</subject><subject>REM Sleep Behavior Disorder - etiology</subject><subject>Sleep Stages</subject><subject>Sleep, REM</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkDtPwzAURi0EoqUwsqIMCJam-JE47oiq8lJ5CIFgM3Z8IwxpUnyTov57WloJpjucc7_hEHLI6IBxxs9e7iaDVAzUgCmptkiXpVzGUvDXbdKllKtYqEx1yB7iB6VLmA13SYfRVAqZJF3ydtPOofIlRA8mfPoK6-oUI-cRDEL07Zv36HF8G2EJMIssvJu5r8OK18FB6K-BrwCxH5nKRc4sGj-F36e6Qmj2yU5hSoSDze2R54vx0-gqntxfXo_OJ3EumGpiVwB3nObWZMolIpOUgnWpSqSw0jlRJJAVRZ7IoXXGWMMEM5ZaUUhnwfJE9MjJencW6q8WsNFTjzmUpamgblHLIc-4pCsxXot5qBEDFHoW_NSEhWZUr5LqZVKdCq30KunSP9oMt3YK7p-9brgUjjeCwdyURTBV7vHPY0pIScUPzc1_0g</recordid><startdate>19991110</startdate><enddate>19991110</enddate><creator>RYE, D. B</creator><creator>JOHNSTON, L. H</creator><creator>WATTS, R. L</creator><creator>BLIWISE, D. L</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991110</creationdate><title>Juvenile Parkinson's disease with REM sleep behavior disorder, sleepiness, and daytime REM onset</title><author>RYE, D. B ; JOHNSTON, L. H ; WATTS, R. L ; BLIWISE, D. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c318t-dfe2d20cba78d437600ebd58463b6dd3f4e7ffc469bdaaba131ab0b3f6dbeb243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adolescent Behavior</topic><topic>Biological and medical sciences</topic><topic>Circadian Rhythm</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Diagnosis, Differential</topic><topic>Diseases in Twins</topic><topic>Electromyography</topic><topic>Female</topic><topic>Genotype</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Narcolepsy - diagnosis</topic><topic>Narcolepsy - genetics</topic><topic>Neurology</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson Disease - psychology</topic><topic>REM Sleep Behavior Disorder - diagnosis</topic><topic>REM Sleep Behavior Disorder - etiology</topic><topic>Sleep Stages</topic><topic>Sleep, REM</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RYE, D. B</creatorcontrib><creatorcontrib>JOHNSTON, L. H</creatorcontrib><creatorcontrib>WATTS, R. L</creatorcontrib><creatorcontrib>BLIWISE, D. 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L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Juvenile Parkinson's disease with REM sleep behavior disorder, sleepiness, and daytime REM onset</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>1999-11-10</date><risdate>1999</risdate><volume>53</volume><issue>8</issue><spage>1868</spage><epage>1870</epage><pages>1868-1870</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><coden>NEURAI</coden><abstract>We describe an unmedicated patient with juvenile PD with difficulties maintaining wakefulness and the atonia of REM sleep. Laboratory testing showed enhanced muscle activity in REM sleep consistent with a history of dream enactment behavior (i.e., REM sleep behavior disorder) and daytime sleepiness, and REM-sleep onsets on multiple sleep latency testing. The results emphasize the potential role of dopamine and basal ganglia circuits in the modulation of activated behavioral states (e.g., wakefulness and REM sleep).</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>10563644</pmid><doi>10.1212/WNL.53.8.1868</doi><tpages>3</tpages></addata></record> |
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| ispartof | Neurology, 1999-11, Vol.53 (8), p.1868-1870 |
| issn | 0028-3878 1526-632X |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Adolescent Adolescent Behavior Biological and medical sciences Circadian Rhythm Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diagnosis, Differential Diseases in Twins Electromyography Female Genotype Humans Medical sciences Narcolepsy - diagnosis Narcolepsy - genetics Neurology Parkinson Disease - physiopathology Parkinson Disease - psychology REM Sleep Behavior Disorder - diagnosis REM Sleep Behavior Disorder - etiology Sleep Stages Sleep, REM |
| title | Juvenile Parkinson's disease with REM sleep behavior disorder, sleepiness, and daytime REM onset |
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