Accelerating functional recovery after rat facial nerve injury: Effects of gonadal steroids and electrical stimulation
We investigated the combined effects of electrical stimulation and testosterone propionate on overall recovery time in rats with extracranial crush injuries to the facial nerve. Male rats underwent castration 3 to 5 days prior to right facial nerve crush injury and electrode implantation. Rats were...
Gespeichert in:
| Veröffentlicht in: | Otolaryngology-head and neck surgery 2008-07, Vol.139 (1), p.62-67 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 67 |
|---|---|
| container_issue | 1 |
| container_start_page | 62 |
| container_title | Otolaryngology-head and neck surgery |
| container_volume | 139 |
| creator | Hetzler, Laura E.T. Sharma, Nijee Tanzer, Lisa Wurster, Robert D. Leonetti, John Marzo, Sam J. Jones, Kathryn J. Foecking, Eileen M. |
| description | We investigated the combined effects of electrical stimulation and testosterone propionate on overall recovery time in rats with extracranial crush injuries to the facial nerve.
Male rats underwent castration 3 to 5 days prior to right facial nerve crush injury and electrode implantation. Rats were randomly assigned to two groups: crush injury + testosterone or crush injury with electrical stimulation + testosterone. Recovery was assessed by daily subjective examination documenting vibrissae orientation/movement, semi–eye blink, and full eye blink.
Milestones of early recovery were noted to be significantly earlier in the groups with electrical stimulation, with/without testosterone. The addition of testosterone to electrical stimulation showed significant earlier return of late recovery parameters and complete overall recovery.
Electrical stimulation may decrease cell death or promote sprouting to accelerate early recovery. Testosterone may affect the actual rate of axonal regeneration and produce acceleration in functional recovery. By targeting different stages of neural regeneration, the synergy of electrical stimulation and testosterone appears to have promise as a neurotherapeutic strategy for facial nerve injury. |
| doi_str_mv | 10.1016/j.otohns.2008.02.006 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69271959</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1016_j.otohns.2008.02.006</sage_id><els_id>S0194599808001125</els_id><sourcerecordid>69271959</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4553-6316317d57bf4acea0c372ec1591090ed00c99abb0a871cce71ab9049972da383</originalsourceid><addsrcrecordid>eNqNkV-L1DAUxYMo7rj6DUTy5Fu7N23TNCLCuuwfYXFf9Dmkyc2Y0mnWpJ1lvr0ZO-CbCoFA8jsnOecS8pZByYC1F0MZ5vBjSmUF0JVQlQDtM7JhIEXRdkw8Jxtgsim4lN0ZeZXSAJlohXhJzljHO87bekP2l8bgiFHPftpSt0xm9mHSI41owh7jgWo3Y6QZoE4bn28mjHukfhqWePhAr51DMycaHN1moc1AyoLgbaJ6sjSbmzl68_vc75ZRHx94TV44PSZ8c9rPyfeb629Xd8X9w-2Xq8v7wjSc10Vbs7yE5aJ3jTaowdSiQsO4zDkBLYCRUvc96E6wnEQw3UtopBSV1XVXn5P3q-9jDD8XTLPa-ZQDj3rCsCTVykowyWUGmxU0MaQU0anH6Hc6HhQDdexbDWrtWx37VlCp3GaWvTv5L_0O7R_RqeAMfFyBJz_i4b9M1cPd1883TDA4ytkqT3qLaghLzLNJ__rTp1WDudi9x6iS8TgZtD4PdVY2-L8b_AJus7jK</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69271959</pqid></control><display><type>article</type><title>Accelerating functional recovery after rat facial nerve injury: Effects of gonadal steroids and electrical stimulation</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>SAGE Complete</source><source>Alma/SFX Local Collection</source><creator>Hetzler, Laura E.T. ; Sharma, Nijee ; Tanzer, Lisa ; Wurster, Robert D. ; Leonetti, John ; Marzo, Sam J. ; Jones, Kathryn J. ; Foecking, Eileen M.</creator><creatorcontrib>Hetzler, Laura E.T. ; Sharma, Nijee ; Tanzer, Lisa ; Wurster, Robert D. ; Leonetti, John ; Marzo, Sam J. ; Jones, Kathryn J. ; Foecking, Eileen M.</creatorcontrib><description>We investigated the combined effects of electrical stimulation and testosterone propionate on overall recovery time in rats with extracranial crush injuries to the facial nerve.
Male rats underwent castration 3 to 5 days prior to right facial nerve crush injury and electrode implantation. Rats were randomly assigned to two groups: crush injury + testosterone or crush injury with electrical stimulation + testosterone. Recovery was assessed by daily subjective examination documenting vibrissae orientation/movement, semi–eye blink, and full eye blink.
Milestones of early recovery were noted to be significantly earlier in the groups with electrical stimulation, with/without testosterone. The addition of testosterone to electrical stimulation showed significant earlier return of late recovery parameters and complete overall recovery.
Electrical stimulation may decrease cell death or promote sprouting to accelerate early recovery. Testosterone may affect the actual rate of axonal regeneration and produce acceleration in functional recovery. By targeting different stages of neural regeneration, the synergy of electrical stimulation and testosterone appears to have promise as a neurotherapeutic strategy for facial nerve injury.</description><identifier>ISSN: 0194-5998</identifier><identifier>EISSN: 1097-6817</identifier><identifier>DOI: 10.1016/j.otohns.2008.02.006</identifier><identifier>PMID: 18585563</identifier><language>eng</language><publisher>Los Angeles, CA: Mosby, Inc</publisher><subject>Animals ; Combined Modality Therapy ; Electric Stimulation Therapy ; Electrodes, Implanted ; Facial Nerve Injuries - therapy ; Male ; Rats ; Rats, Sprague-Dawley ; Testosterone Propionate - administration & dosage ; Testosterone Propionate - therapeutic use ; Wound Healing - drug effects ; Wound Healing - physiology</subject><ispartof>Otolaryngology-head and neck surgery, 2008-07, Vol.139 (1), p.62-67</ispartof><rights>2008 American Academy of Otolaryngology–Head and Neck Surgery Foundation</rights><rights>2008 SAGE Publications</rights><rights>2008 American Association of Otolaryngology‐Head and Neck Surgery Foundation (AAO‐HNSF)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4553-6316317d57bf4acea0c372ec1591090ed00c99abb0a871cce71ab9049972da383</citedby><cites>FETCH-LOGICAL-c4553-6316317d57bf4acea0c372ec1591090ed00c99abb0a871cce71ab9049972da383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1016/j.otohns.2008.02.006$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1016/j.otohns.2008.02.006$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,1411,21798,27901,27902,43597,43598,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18585563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hetzler, Laura E.T.</creatorcontrib><creatorcontrib>Sharma, Nijee</creatorcontrib><creatorcontrib>Tanzer, Lisa</creatorcontrib><creatorcontrib>Wurster, Robert D.</creatorcontrib><creatorcontrib>Leonetti, John</creatorcontrib><creatorcontrib>Marzo, Sam J.</creatorcontrib><creatorcontrib>Jones, Kathryn J.</creatorcontrib><creatorcontrib>Foecking, Eileen M.</creatorcontrib><title>Accelerating functional recovery after rat facial nerve injury: Effects of gonadal steroids and electrical stimulation</title><title>Otolaryngology-head and neck surgery</title><addtitle>Otolaryngol Head Neck Surg</addtitle><description>We investigated the combined effects of electrical stimulation and testosterone propionate on overall recovery time in rats with extracranial crush injuries to the facial nerve.
Male rats underwent castration 3 to 5 days prior to right facial nerve crush injury and electrode implantation. Rats were randomly assigned to two groups: crush injury + testosterone or crush injury with electrical stimulation + testosterone. Recovery was assessed by daily subjective examination documenting vibrissae orientation/movement, semi–eye blink, and full eye blink.
Milestones of early recovery were noted to be significantly earlier in the groups with electrical stimulation, with/without testosterone. The addition of testosterone to electrical stimulation showed significant earlier return of late recovery parameters and complete overall recovery.
Electrical stimulation may decrease cell death or promote sprouting to accelerate early recovery. Testosterone may affect the actual rate of axonal regeneration and produce acceleration in functional recovery. By targeting different stages of neural regeneration, the synergy of electrical stimulation and testosterone appears to have promise as a neurotherapeutic strategy for facial nerve injury.</description><subject>Animals</subject><subject>Combined Modality Therapy</subject><subject>Electric Stimulation Therapy</subject><subject>Electrodes, Implanted</subject><subject>Facial Nerve Injuries - therapy</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Testosterone Propionate - administration & dosage</subject><subject>Testosterone Propionate - therapeutic use</subject><subject>Wound Healing - drug effects</subject><subject>Wound Healing - physiology</subject><issn>0194-5998</issn><issn>1097-6817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV-L1DAUxYMo7rj6DUTy5Fu7N23TNCLCuuwfYXFf9Dmkyc2Y0mnWpJ1lvr0ZO-CbCoFA8jsnOecS8pZByYC1F0MZ5vBjSmUF0JVQlQDtM7JhIEXRdkw8Jxtgsim4lN0ZeZXSAJlohXhJzljHO87bekP2l8bgiFHPftpSt0xm9mHSI41owh7jgWo3Y6QZoE4bn28mjHukfhqWePhAr51DMycaHN1moc1AyoLgbaJ6sjSbmzl68_vc75ZRHx94TV44PSZ8c9rPyfeb629Xd8X9w-2Xq8v7wjSc10Vbs7yE5aJ3jTaowdSiQsO4zDkBLYCRUvc96E6wnEQw3UtopBSV1XVXn5P3q-9jDD8XTLPa-ZQDj3rCsCTVykowyWUGmxU0MaQU0anH6Hc6HhQDdexbDWrtWx37VlCp3GaWvTv5L_0O7R_RqeAMfFyBJz_i4b9M1cPd1883TDA4ytkqT3qLaghLzLNJ__rTp1WDudi9x6iS8TgZtD4PdVY2-L8b_AJus7jK</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Hetzler, Laura E.T.</creator><creator>Sharma, Nijee</creator><creator>Tanzer, Lisa</creator><creator>Wurster, Robert D.</creator><creator>Leonetti, John</creator><creator>Marzo, Sam J.</creator><creator>Jones, Kathryn J.</creator><creator>Foecking, Eileen M.</creator><general>Mosby, Inc</general><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>200807</creationdate><title>Accelerating functional recovery after rat facial nerve injury: Effects of gonadal steroids and electrical stimulation</title><author>Hetzler, Laura E.T. ; Sharma, Nijee ; Tanzer, Lisa ; Wurster, Robert D. ; Leonetti, John ; Marzo, Sam J. ; Jones, Kathryn J. ; Foecking, Eileen M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4553-6316317d57bf4acea0c372ec1591090ed00c99abb0a871cce71ab9049972da383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Combined Modality Therapy</topic><topic>Electric Stimulation Therapy</topic><topic>Electrodes, Implanted</topic><topic>Facial Nerve Injuries - therapy</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Testosterone Propionate - administration & dosage</topic><topic>Testosterone Propionate - therapeutic use</topic><topic>Wound Healing - drug effects</topic><topic>Wound Healing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hetzler, Laura E.T.</creatorcontrib><creatorcontrib>Sharma, Nijee</creatorcontrib><creatorcontrib>Tanzer, Lisa</creatorcontrib><creatorcontrib>Wurster, Robert D.</creatorcontrib><creatorcontrib>Leonetti, John</creatorcontrib><creatorcontrib>Marzo, Sam J.</creatorcontrib><creatorcontrib>Jones, Kathryn J.</creatorcontrib><creatorcontrib>Foecking, Eileen M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Otolaryngology-head and neck surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hetzler, Laura E.T.</au><au>Sharma, Nijee</au><au>Tanzer, Lisa</au><au>Wurster, Robert D.</au><au>Leonetti, John</au><au>Marzo, Sam J.</au><au>Jones, Kathryn J.</au><au>Foecking, Eileen M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Accelerating functional recovery after rat facial nerve injury: Effects of gonadal steroids and electrical stimulation</atitle><jtitle>Otolaryngology-head and neck surgery</jtitle><addtitle>Otolaryngol Head Neck Surg</addtitle><date>2008-07</date><risdate>2008</risdate><volume>139</volume><issue>1</issue><spage>62</spage><epage>67</epage><pages>62-67</pages><issn>0194-5998</issn><eissn>1097-6817</eissn><abstract>We investigated the combined effects of electrical stimulation and testosterone propionate on overall recovery time in rats with extracranial crush injuries to the facial nerve.
Male rats underwent castration 3 to 5 days prior to right facial nerve crush injury and electrode implantation. Rats were randomly assigned to two groups: crush injury + testosterone or crush injury with electrical stimulation + testosterone. Recovery was assessed by daily subjective examination documenting vibrissae orientation/movement, semi–eye blink, and full eye blink.
Milestones of early recovery were noted to be significantly earlier in the groups with electrical stimulation, with/without testosterone. The addition of testosterone to electrical stimulation showed significant earlier return of late recovery parameters and complete overall recovery.
Electrical stimulation may decrease cell death or promote sprouting to accelerate early recovery. Testosterone may affect the actual rate of axonal regeneration and produce acceleration in functional recovery. By targeting different stages of neural regeneration, the synergy of electrical stimulation and testosterone appears to have promise as a neurotherapeutic strategy for facial nerve injury.</abstract><cop>Los Angeles, CA</cop><pub>Mosby, Inc</pub><pmid>18585563</pmid><doi>10.1016/j.otohns.2008.02.006</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0194-5998 |
| ispartof | Otolaryngology-head and neck surgery, 2008-07, Vol.139 (1), p.62-67 |
| issn | 0194-5998 1097-6817 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69271959 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; SAGE Complete; Alma/SFX Local Collection |
| subjects | Animals Combined Modality Therapy Electric Stimulation Therapy Electrodes, Implanted Facial Nerve Injuries - therapy Male Rats Rats, Sprague-Dawley Testosterone Propionate - administration & dosage Testosterone Propionate - therapeutic use Wound Healing - drug effects Wound Healing - physiology |
| title | Accelerating functional recovery after rat facial nerve injury: Effects of gonadal steroids and electrical stimulation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T04%3A35%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Accelerating%20functional%20recovery%20after%20rat%20facial%20nerve%20injury:%20Effects%20of%20gonadal%20steroids%20and%20electrical%20stimulation&rft.jtitle=Otolaryngology-head%20and%20neck%20surgery&rft.au=Hetzler,%20Laura%20E.T.&rft.date=2008-07&rft.volume=139&rft.issue=1&rft.spage=62&rft.epage=67&rft.pages=62-67&rft.issn=0194-5998&rft.eissn=1097-6817&rft_id=info:doi/10.1016/j.otohns.2008.02.006&rft_dat=%3Cproquest_cross%3E69271959%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69271959&rft_id=info:pmid/18585563&rft_sage_id=10.1016_j.otohns.2008.02.006&rft_els_id=S0194599808001125&rfr_iscdi=true |