Carcinoid syndrome caused by an atypical carcinoid of the uterine cervix
Neuroendocrine tumors of the cervix are rare and are often under- or misdiagnosed. Because these tumors are very aggressive, early diagnosis and subsequent treatment are warranted. We describe a 46-yr-old woman with carcinoid syndrome caused by an atypical carcinoid of the uterine cervix. At age 44,...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 1999-11, Vol.84 (11), p.4209-4213 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | KOCH, C. A AZUMI, N FURLONG, M. A JHA, R. C KEHOE, T. E TROWBRIDGE, C. H O'DORISIO, T. M CHROUSOS, G. P CLEMENT, S. C |
| description | Neuroendocrine tumors of the cervix are rare and are often under- or misdiagnosed. Because these tumors are very aggressive, early diagnosis and subsequent treatment are warranted. We describe a 46-yr-old woman with carcinoid syndrome caused by an atypical carcinoid of the uterine cervix. At age 44, she had dysplasia on Pap smear and underwent total abdominal hysterectomy with the diagnosis of adenocarcinoma. Fourteen months postoperatively, she developed the carcinoid syndrome and was found to have numerous liver metastases. Histological and immunohistochemical investigations of biopsy specimens from the patient's liver lesions and original cervical lesion ("adenocarcinoma") suggested that this woman had a primary atypical carcinoid of the uterine cervix with metastases to the liver. Treatment with octreotide and alkylating agents decreased the episodes of flushing and diarrhea within 8 weeks. If an adenocarcinoma of the uterine cervix is diagnosed, atypical carcinoid should be in the differential diagnosis. Symptoms of the carcinoid syndrome should be pursued and, if present, a urinary 5-hydroxyindolacetic acid level should be obtained. Timely diagnosis of a neuroendocrine tumor of the cervix may improve survival. |
| doi_str_mv | 10.1210/jc.84.11.4209 |
| format | Article |
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A ; AZUMI, N ; FURLONG, M. A ; JHA, R. C ; KEHOE, T. E ; TROWBRIDGE, C. H ; O'DORISIO, T. M ; CHROUSOS, G. P ; CLEMENT, S. C</creator><creatorcontrib>KOCH, C. A ; AZUMI, N ; FURLONG, M. A ; JHA, R. C ; KEHOE, T. E ; TROWBRIDGE, C. H ; O'DORISIO, T. M ; CHROUSOS, G. P ; CLEMENT, S. C</creatorcontrib><description>Neuroendocrine tumors of the cervix are rare and are often under- or misdiagnosed. Because these tumors are very aggressive, early diagnosis and subsequent treatment are warranted. We describe a 46-yr-old woman with carcinoid syndrome caused by an atypical carcinoid of the uterine cervix. At age 44, she had dysplasia on Pap smear and underwent total abdominal hysterectomy with the diagnosis of adenocarcinoma. Fourteen months postoperatively, she developed the carcinoid syndrome and was found to have numerous liver metastases. Histological and immunohistochemical investigations of biopsy specimens from the patient's liver lesions and original cervical lesion ("adenocarcinoma") suggested that this woman had a primary atypical carcinoid of the uterine cervix with metastases to the liver. Treatment with octreotide and alkylating agents decreased the episodes of flushing and diarrhea within 8 weeks. If an adenocarcinoma of the uterine cervix is diagnosed, atypical carcinoid should be in the differential diagnosis. Symptoms of the carcinoid syndrome should be pursued and, if present, a urinary 5-hydroxyindolacetic acid level should be obtained. Timely diagnosis of a neuroendocrine tumor of the cervix may improve survival.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.84.11.4209</identifier><identifier>PMID: 10566674</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adenocarcinoma ; Antineoplastic Agents, Hormonal - therapeutic use ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Carcinoid Tumor - diagnosis ; Carcinoid Tumor - secondary ; Carcinoid Tumor - therapy ; Diagnosis, Differential ; Endocrinopathies ; Female ; Female genital diseases ; General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Liver Neoplasms - drug therapy ; Liver Neoplasms - secondary ; Magnetic Resonance Imaging ; Medical sciences ; Middle Aged ; Octreotide - administration & dosage ; Pancreatic Neoplasms - drug therapy ; Pancreatic Neoplasms - secondary ; Papanicolaou Test ; Syndrome ; Tumors ; Uterine Cervical Neoplasms - diagnosis ; Uterine Cervical Neoplasms - therapy ; Vaginal Smears</subject><ispartof>The journal of clinical endocrinology and metabolism, 1999-11, Vol.84 (11), p.4209-4213</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-10161850d3442a4bb442a48ffd5cb37bd7ce490ec716ba67f5bca3162d1e673a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1998911$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10566674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOCH, C. A</creatorcontrib><creatorcontrib>AZUMI, N</creatorcontrib><creatorcontrib>FURLONG, M. A</creatorcontrib><creatorcontrib>JHA, R. C</creatorcontrib><creatorcontrib>KEHOE, T. E</creatorcontrib><creatorcontrib>TROWBRIDGE, C. H</creatorcontrib><creatorcontrib>O'DORISIO, T. M</creatorcontrib><creatorcontrib>CHROUSOS, G. P</creatorcontrib><creatorcontrib>CLEMENT, S. C</creatorcontrib><title>Carcinoid syndrome caused by an atypical carcinoid of the uterine cervix</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Neuroendocrine tumors of the cervix are rare and are often under- or misdiagnosed. Because these tumors are very aggressive, early diagnosis and subsequent treatment are warranted. We describe a 46-yr-old woman with carcinoid syndrome caused by an atypical carcinoid of the uterine cervix. At age 44, she had dysplasia on Pap smear and underwent total abdominal hysterectomy with the diagnosis of adenocarcinoma. Fourteen months postoperatively, she developed the carcinoid syndrome and was found to have numerous liver metastases. Histological and immunohistochemical investigations of biopsy specimens from the patient's liver lesions and original cervical lesion ("adenocarcinoma") suggested that this woman had a primary atypical carcinoid of the uterine cervix with metastases to the liver. Treatment with octreotide and alkylating agents decreased the episodes of flushing and diarrhea within 8 weeks. If an adenocarcinoma of the uterine cervix is diagnosed, atypical carcinoid should be in the differential diagnosis. Symptoms of the carcinoid syndrome should be pursued and, if present, a urinary 5-hydroxyindolacetic acid level should be obtained. Timely diagnosis of a neuroendocrine tumor of the cervix may improve survival.</description><subject>Adenocarcinoma</subject><subject>Antineoplastic Agents, Hormonal - therapeutic use</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Carcinoid Tumor - diagnosis</subject><subject>Carcinoid Tumor - secondary</subject><subject>Carcinoid Tumor - therapy</subject><subject>Diagnosis, Differential</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Liver Neoplasms - secondary</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Octreotide - administration & dosage</subject><subject>Pancreatic Neoplasms - drug therapy</subject><subject>Pancreatic Neoplasms - secondary</subject><subject>Papanicolaou Test</subject><subject>Syndrome</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - diagnosis</subject><subject>Uterine Cervical Neoplasms - therapy</subject><subject>Vaginal Smears</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFz01LxDAYBOAgiruuHr1KDuKtNW-SJs1RFnWFBS8K3kq-iln6sSat2H9v0RVPA8PDwCB0CSQHCuR2Z_OS5wA5p0QdoSUoXmQSlDxGS0IoZErStwU6S2lHCHBesFO0AFIIISRfos1aRxu6Pjicps7FvvXY6jF5h82EdYf1MO2D1c3c_sG-xsO7x-PgY-hm7uNn-DpHJ7Vukr845Aq9Pty_rDfZ9vnxaX23zSwDOWRAQEBZEMc4p5ob8xNlXbvCGiaNk9ZzRbyVIIwWsi6M1QwEdeCFZJqt0M3v7j72H6NPQ9WGZH3T6M73Y6qEohIYgRleHeBoWu-qfQytjlP1930G1weg03ywjrqzIf07pUoFwL4BREhnoA</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>KOCH, C. A</creator><creator>AZUMI, N</creator><creator>FURLONG, M. A</creator><creator>JHA, R. C</creator><creator>KEHOE, T. E</creator><creator>TROWBRIDGE, C. H</creator><creator>O'DORISIO, T. M</creator><creator>CHROUSOS, G. P</creator><creator>CLEMENT, S. C</creator><general>Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19991101</creationdate><title>Carcinoid syndrome caused by an atypical carcinoid of the uterine cervix</title><author>KOCH, C. A ; AZUMI, N ; FURLONG, M. A ; JHA, R. C ; KEHOE, T. E ; TROWBRIDGE, C. H ; O'DORISIO, T. M ; CHROUSOS, G. P ; CLEMENT, S. 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Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Liver Neoplasms - secondary</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Octreotide - administration & dosage</topic><topic>Pancreatic Neoplasms - drug therapy</topic><topic>Pancreatic Neoplasms - secondary</topic><topic>Papanicolaou Test</topic><topic>Syndrome</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - diagnosis</topic><topic>Uterine Cervical Neoplasms - therapy</topic><topic>Vaginal Smears</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOCH, C. A</creatorcontrib><creatorcontrib>AZUMI, N</creatorcontrib><creatorcontrib>FURLONG, M. A</creatorcontrib><creatorcontrib>JHA, R. C</creatorcontrib><creatorcontrib>KEHOE, T. E</creatorcontrib><creatorcontrib>TROWBRIDGE, C. H</creatorcontrib><creatorcontrib>O'DORISIO, T. 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C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carcinoid syndrome caused by an atypical carcinoid of the uterine cervix</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>84</volume><issue>11</issue><spage>4209</spage><epage>4213</epage><pages>4209-4213</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Neuroendocrine tumors of the cervix are rare and are often under- or misdiagnosed. Because these tumors are very aggressive, early diagnosis and subsequent treatment are warranted. We describe a 46-yr-old woman with carcinoid syndrome caused by an atypical carcinoid of the uterine cervix. At age 44, she had dysplasia on Pap smear and underwent total abdominal hysterectomy with the diagnosis of adenocarcinoma. 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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Adenocarcinoma Antineoplastic Agents, Hormonal - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Carcinoid Tumor - diagnosis Carcinoid Tumor - secondary Carcinoid Tumor - therapy Diagnosis, Differential Endocrinopathies Female Female genital diseases General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Liver Neoplasms - drug therapy Liver Neoplasms - secondary Magnetic Resonance Imaging Medical sciences Middle Aged Octreotide - administration & dosage Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - secondary Papanicolaou Test Syndrome Tumors Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - therapy Vaginal Smears |
| title | Carcinoid syndrome caused by an atypical carcinoid of the uterine cervix |
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