Trastuzumab in the Adjuvant Treatment of Early‐Stage Breast Cancer: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials
Learning Objectives After completing this course, the reader will be able to: Summarize the main characteristics and findings of randomized controlled trials evaluating trastuzumab for the adjuvant treatment of early‐stage breast cancer. Use combined‐effect estimates provided by meta‐analysis to app...
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| Veröffentlicht in: | The oncologist (Dayton, Ohio) Ohio), 2008-06, Vol.13 (6), p.620-630 |
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| creator | Dahabreh, Issa J. Linardou, Helen Siannis, Fotios Fountzilas, George Murray, Samuel |
| description | Learning Objectives
After completing this course, the reader will be able to:
Summarize the main characteristics and findings of randomized controlled trials evaluating trastuzumab for the adjuvant treatment of early‐stage breast cancer.
Use combined‐effect estimates provided by meta‐analysis to appraise the risks and benefits of trastuzumab treatment in the adjuvant setting.
Identify the links between basic science and drug development that led to the successful clinical use of trastuzumab, as well as the gaps in the existing evidence base regarding its use in breast cancer treatment.
Access and take the CME test online and receive 1 AMA PRA Category 1 Credit™ at CME.TheOncologist.com
Background.
We performed a systematic review and meta‐analysis to compare treatment outcomes for human epidermal growth factor receptor (HER)‐2–positive breast cancer patients receiving adjuvant chemotherapy with or without trastuzumab.
Methods.
We identified randomized clinical trials comparing adjuvant chemotherapy with or without trastuzumab in patients with resectable breast cancer. Fixed‐effects meta‐analysis was used to combine data.
Results.
Five eligible trials were identified, reporting outcomes on 13,493 women. Fixed‐effects analysis showed disease‐free survival to be superior for trastuzumab‐treated patients (risk ratio [RR], 0.62; 95% confidence interval [CI], 0.56–0.68). Superiority was also observed for patients receiving trastuzumab with respect to mortality (RR, 0.66; 95% CI, 0.57–0.77), locoregional recurrence (RR, 0.58; 95% CI, 0.43–0.77), and distant recurrence (RR, 0.60; 95% CI, 0.52–0.68). Patients receiving trastuzumab with chemotherapy had a higher risk for congestive heart failure (RR, 7.60; 95% CI, 4.07–14.18) and left ventricular ejection fraction decline (RR, 2.09; 95% CI, 1.84–2.37). A higher risk for central nervous system metastasis as the first recurrence event (RR, 1.60; 95% CI, 1.06–2.40) was also noted in patients receiving trastuzumab.
Conclusions.
The use of trastuzumab should be considered an integral part of the adjuvant therapy of HER‐2–positive breast cancer patients.
A systematic review and meta‐analysis to compare treatment outcomes for human epidermal growth factor receptor 2–positive breast cancer patients receiving adjuvant chemotherapy with or without trastuzumab are reported. The results support the use of trastuzumab, especially in patients at low risk for cardiovascular morbidity. |
| doi_str_mv | 10.1634/theoncologist.2008-0001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69270752</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69270752</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5200-8445e283e0d26ee10ef1f66428b72730384ce92ebf1f4cadecc47513d051bbd83</originalsourceid><addsrcrecordid>eNqNkc9qFTEYxYMotlZfQbNyNzV_54_g4jpULbReaK_gLmQy39SUzKQmmZbpyhcQfEafpLncC9Kdq-_w5XdOSA5Cbyg5piUX79IP8JPxzl_ZmI4ZIXVBCKFP0CGVoilEQ74_zZrUvKiobA7QixivMyAbzp6jA1rLumxodYh-b4KOab6fR91hO-EcjFf99Xyrp4Q3AXQaISs_4BMd3PL315_LpK8Af8xHMeFWTwbCe7zCl0tMMOpkDb6AWwt3WE89Poeks2c1abdEG7c5F3nvR3sPPW79lIJ3LstNsNrFl-jZkAe82s8j9O3Tyab9UpytP5-2q7PCyPzWohZCAqs5kJ6VAJTAQIeyFKzuKlZxwmthoGHQ5bUwugdjRCUp74mkXdfX_Ai93eXeBP9zhpjUaKMB5_QEfo6qbFhFKskyWO1AE3yMAQZ1E-yow6IoUdsm1KMm1LYJtW0iO1_vr5i7Efp_vv3XZ-DDDrizDpb_zVXrr-2alIzwB82PoWE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69270752</pqid></control><display><type>article</type><title>Trastuzumab in the Adjuvant Treatment of Early‐Stage Breast Cancer: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials</title><source>Oxford Journals Open Access Collection</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Dahabreh, Issa J. ; Linardou, Helen ; Siannis, Fotios ; Fountzilas, George ; Murray, Samuel</creator><creatorcontrib>Dahabreh, Issa J. ; Linardou, Helen ; Siannis, Fotios ; Fountzilas, George ; Murray, Samuel</creatorcontrib><description>Learning Objectives
After completing this course, the reader will be able to:
Summarize the main characteristics and findings of randomized controlled trials evaluating trastuzumab for the adjuvant treatment of early‐stage breast cancer.
Use combined‐effect estimates provided by meta‐analysis to appraise the risks and benefits of trastuzumab treatment in the adjuvant setting.
Identify the links between basic science and drug development that led to the successful clinical use of trastuzumab, as well as the gaps in the existing evidence base regarding its use in breast cancer treatment.
Access and take the CME test online and receive 1 AMA PRA Category 1 Credit™ at CME.TheOncologist.com
Background.
We performed a systematic review and meta‐analysis to compare treatment outcomes for human epidermal growth factor receptor (HER)‐2–positive breast cancer patients receiving adjuvant chemotherapy with or without trastuzumab.
Methods.
We identified randomized clinical trials comparing adjuvant chemotherapy with or without trastuzumab in patients with resectable breast cancer. Fixed‐effects meta‐analysis was used to combine data.
Results.
Five eligible trials were identified, reporting outcomes on 13,493 women. Fixed‐effects analysis showed disease‐free survival to be superior for trastuzumab‐treated patients (risk ratio [RR], 0.62; 95% confidence interval [CI], 0.56–0.68). Superiority was also observed for patients receiving trastuzumab with respect to mortality (RR, 0.66; 95% CI, 0.57–0.77), locoregional recurrence (RR, 0.58; 95% CI, 0.43–0.77), and distant recurrence (RR, 0.60; 95% CI, 0.52–0.68). Patients receiving trastuzumab with chemotherapy had a higher risk for congestive heart failure (RR, 7.60; 95% CI, 4.07–14.18) and left ventricular ejection fraction decline (RR, 2.09; 95% CI, 1.84–2.37). A higher risk for central nervous system metastasis as the first recurrence event (RR, 1.60; 95% CI, 1.06–2.40) was also noted in patients receiving trastuzumab.
Conclusions.
The use of trastuzumab should be considered an integral part of the adjuvant therapy of HER‐2–positive breast cancer patients.
A systematic review and meta‐analysis to compare treatment outcomes for human epidermal growth factor receptor 2–positive breast cancer patients receiving adjuvant chemotherapy with or without trastuzumab are reported. The results support the use of trastuzumab, especially in patients at low risk for cardiovascular morbidity.</description><identifier>ISSN: 1083-7159</identifier><identifier>EISSN: 1549-490X</identifier><identifier>DOI: 10.1634/theoncologist.2008-0001</identifier><identifier>PMID: 18586917</identifier><language>eng</language><publisher>Durham, NC, USA: AlphaMed Press</publisher><subject>Adjuvant chemotherapy ; Antibodies, Monoclonal - therapeutic use ; Antibodies, Monoclonal, Humanized ; Antineoplastic Agents - therapeutic use ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - metabolism ; Breast Neoplasms - mortality ; Chemotherapy, Adjuvant ; Disease-Free Survival ; Female ; Gene Amplification ; HER‐2 ; Humans ; Immunoenzyme Techniques ; Meta‐analysis ; Neoplasm Staging ; Randomized Controlled Trials as Topic ; Receptor, ErbB-2 - genetics ; Receptor, ErbB-2 - metabolism ; Survival Rate ; Systematic review ; Trastuzumab ; Treatment Outcome</subject><ispartof>The oncologist (Dayton, Ohio), 2008-06, Vol.13 (6), p.620-630</ispartof><rights>2008 AlphaMed Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5200-8445e283e0d26ee10ef1f66428b72730384ce92ebf1f4cadecc47513d051bbd83</citedby><cites>FETCH-LOGICAL-c5200-8445e283e0d26ee10ef1f66428b72730384ce92ebf1f4cadecc47513d051bbd83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1634%2Ftheoncologist.2008-0001$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1634%2Ftheoncologist.2008-0001$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18586917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dahabreh, Issa J.</creatorcontrib><creatorcontrib>Linardou, Helen</creatorcontrib><creatorcontrib>Siannis, Fotios</creatorcontrib><creatorcontrib>Fountzilas, George</creatorcontrib><creatorcontrib>Murray, Samuel</creatorcontrib><title>Trastuzumab in the Adjuvant Treatment of Early‐Stage Breast Cancer: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials</title><title>The oncologist (Dayton, Ohio)</title><addtitle>Oncologist</addtitle><description>Learning Objectives
After completing this course, the reader will be able to:
Summarize the main characteristics and findings of randomized controlled trials evaluating trastuzumab for the adjuvant treatment of early‐stage breast cancer.
Use combined‐effect estimates provided by meta‐analysis to appraise the risks and benefits of trastuzumab treatment in the adjuvant setting.
Identify the links between basic science and drug development that led to the successful clinical use of trastuzumab, as well as the gaps in the existing evidence base regarding its use in breast cancer treatment.
Access and take the CME test online and receive 1 AMA PRA Category 1 Credit™ at CME.TheOncologist.com
Background.
We performed a systematic review and meta‐analysis to compare treatment outcomes for human epidermal growth factor receptor (HER)‐2–positive breast cancer patients receiving adjuvant chemotherapy with or without trastuzumab.
Methods.
We identified randomized clinical trials comparing adjuvant chemotherapy with or without trastuzumab in patients with resectable breast cancer. Fixed‐effects meta‐analysis was used to combine data.
Results.
Five eligible trials were identified, reporting outcomes on 13,493 women. Fixed‐effects analysis showed disease‐free survival to be superior for trastuzumab‐treated patients (risk ratio [RR], 0.62; 95% confidence interval [CI], 0.56–0.68). Superiority was also observed for patients receiving trastuzumab with respect to mortality (RR, 0.66; 95% CI, 0.57–0.77), locoregional recurrence (RR, 0.58; 95% CI, 0.43–0.77), and distant recurrence (RR, 0.60; 95% CI, 0.52–0.68). Patients receiving trastuzumab with chemotherapy had a higher risk for congestive heart failure (RR, 7.60; 95% CI, 4.07–14.18) and left ventricular ejection fraction decline (RR, 2.09; 95% CI, 1.84–2.37). A higher risk for central nervous system metastasis as the first recurrence event (RR, 1.60; 95% CI, 1.06–2.40) was also noted in patients receiving trastuzumab.
Conclusions.
The use of trastuzumab should be considered an integral part of the adjuvant therapy of HER‐2–positive breast cancer patients.
A systematic review and meta‐analysis to compare treatment outcomes for human epidermal growth factor receptor 2–positive breast cancer patients receiving adjuvant chemotherapy with or without trastuzumab are reported. The results support the use of trastuzumab, especially in patients at low risk for cardiovascular morbidity.</description><subject>Adjuvant chemotherapy</subject><subject>Antibodies, Monoclonal - therapeutic use</subject><subject>Antibodies, Monoclonal, Humanized</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - mortality</subject><subject>Chemotherapy, Adjuvant</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gene Amplification</subject><subject>HER‐2</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Meta‐analysis</subject><subject>Neoplasm Staging</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Receptor, ErbB-2 - genetics</subject><subject>Receptor, ErbB-2 - metabolism</subject><subject>Survival Rate</subject><subject>Systematic review</subject><subject>Trastuzumab</subject><subject>Treatment Outcome</subject><issn>1083-7159</issn><issn>1549-490X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9qFTEYxYMotlZfQbNyNzV_54_g4jpULbReaK_gLmQy39SUzKQmmZbpyhcQfEafpLncC9Kdq-_w5XdOSA5Cbyg5piUX79IP8JPxzl_ZmI4ZIXVBCKFP0CGVoilEQ74_zZrUvKiobA7QixivMyAbzp6jA1rLumxodYh-b4KOab6fR91hO-EcjFf99Xyrp4Q3AXQaISs_4BMd3PL315_LpK8Af8xHMeFWTwbCe7zCl0tMMOpkDb6AWwt3WE89Poeks2c1abdEG7c5F3nvR3sPPW79lIJ3LstNsNrFl-jZkAe82s8j9O3Tyab9UpytP5-2q7PCyPzWohZCAqs5kJ6VAJTAQIeyFKzuKlZxwmthoGHQ5bUwugdjRCUp74mkXdfX_Ai93eXeBP9zhpjUaKMB5_QEfo6qbFhFKskyWO1AE3yMAQZ1E-yow6IoUdsm1KMm1LYJtW0iO1_vr5i7Efp_vv3XZ-DDDrizDpb_zVXrr-2alIzwB82PoWE</recordid><startdate>200806</startdate><enddate>200806</enddate><creator>Dahabreh, Issa J.</creator><creator>Linardou, Helen</creator><creator>Siannis, Fotios</creator><creator>Fountzilas, George</creator><creator>Murray, Samuel</creator><general>AlphaMed Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200806</creationdate><title>Trastuzumab in the Adjuvant Treatment of Early‐Stage Breast Cancer: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials</title><author>Dahabreh, Issa J. ; Linardou, Helen ; Siannis, Fotios ; Fountzilas, George ; Murray, Samuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5200-8445e283e0d26ee10ef1f66428b72730384ce92ebf1f4cadecc47513d051bbd83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adjuvant chemotherapy</topic><topic>Antibodies, Monoclonal - therapeutic use</topic><topic>Antibodies, Monoclonal, Humanized</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - mortality</topic><topic>Chemotherapy, Adjuvant</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gene Amplification</topic><topic>HER‐2</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Meta‐analysis</topic><topic>Neoplasm Staging</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Receptor, ErbB-2 - genetics</topic><topic>Receptor, ErbB-2 - metabolism</topic><topic>Survival Rate</topic><topic>Systematic review</topic><topic>Trastuzumab</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dahabreh, Issa J.</creatorcontrib><creatorcontrib>Linardou, Helen</creatorcontrib><creatorcontrib>Siannis, Fotios</creatorcontrib><creatorcontrib>Fountzilas, George</creatorcontrib><creatorcontrib>Murray, Samuel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The oncologist (Dayton, Ohio)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dahabreh, Issa J.</au><au>Linardou, Helen</au><au>Siannis, Fotios</au><au>Fountzilas, George</au><au>Murray, Samuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trastuzumab in the Adjuvant Treatment of Early‐Stage Breast Cancer: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials</atitle><jtitle>The oncologist (Dayton, Ohio)</jtitle><addtitle>Oncologist</addtitle><date>2008-06</date><risdate>2008</risdate><volume>13</volume><issue>6</issue><spage>620</spage><epage>630</epage><pages>620-630</pages><issn>1083-7159</issn><eissn>1549-490X</eissn><abstract>Learning Objectives
After completing this course, the reader will be able to:
Summarize the main characteristics and findings of randomized controlled trials evaluating trastuzumab for the adjuvant treatment of early‐stage breast cancer.
Use combined‐effect estimates provided by meta‐analysis to appraise the risks and benefits of trastuzumab treatment in the adjuvant setting.
Identify the links between basic science and drug development that led to the successful clinical use of trastuzumab, as well as the gaps in the existing evidence base regarding its use in breast cancer treatment.
Access and take the CME test online and receive 1 AMA PRA Category 1 Credit™ at CME.TheOncologist.com
Background.
We performed a systematic review and meta‐analysis to compare treatment outcomes for human epidermal growth factor receptor (HER)‐2–positive breast cancer patients receiving adjuvant chemotherapy with or without trastuzumab.
Methods.
We identified randomized clinical trials comparing adjuvant chemotherapy with or without trastuzumab in patients with resectable breast cancer. Fixed‐effects meta‐analysis was used to combine data.
Results.
Five eligible trials were identified, reporting outcomes on 13,493 women. Fixed‐effects analysis showed disease‐free survival to be superior for trastuzumab‐treated patients (risk ratio [RR], 0.62; 95% confidence interval [CI], 0.56–0.68). Superiority was also observed for patients receiving trastuzumab with respect to mortality (RR, 0.66; 95% CI, 0.57–0.77), locoregional recurrence (RR, 0.58; 95% CI, 0.43–0.77), and distant recurrence (RR, 0.60; 95% CI, 0.52–0.68). Patients receiving trastuzumab with chemotherapy had a higher risk for congestive heart failure (RR, 7.60; 95% CI, 4.07–14.18) and left ventricular ejection fraction decline (RR, 2.09; 95% CI, 1.84–2.37). A higher risk for central nervous system metastasis as the first recurrence event (RR, 1.60; 95% CI, 1.06–2.40) was also noted in patients receiving trastuzumab.
Conclusions.
The use of trastuzumab should be considered an integral part of the adjuvant therapy of HER‐2–positive breast cancer patients.
A systematic review and meta‐analysis to compare treatment outcomes for human epidermal growth factor receptor 2–positive breast cancer patients receiving adjuvant chemotherapy with or without trastuzumab are reported. The results support the use of trastuzumab, especially in patients at low risk for cardiovascular morbidity.</abstract><cop>Durham, NC, USA</cop><pub>AlphaMed Press</pub><pmid>18586917</pmid><doi>10.1634/theoncologist.2008-0001</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1083-7159 |
| ispartof | The oncologist (Dayton, Ohio), 2008-06, Vol.13 (6), p.620-630 |
| issn | 1083-7159 1549-490X |
| language | eng |
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| source | Oxford Journals Open Access Collection; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adjuvant chemotherapy Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Antineoplastic Agents - therapeutic use Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - mortality Chemotherapy, Adjuvant Disease-Free Survival Female Gene Amplification HER‐2 Humans Immunoenzyme Techniques Meta‐analysis Neoplasm Staging Randomized Controlled Trials as Topic Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Survival Rate Systematic review Trastuzumab Treatment Outcome |
| title | Trastuzumab in the Adjuvant Treatment of Early‐Stage Breast Cancer: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials |
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