Rapid and efficient radiosynthesis of [123 I]I-PK11195, a single photon emission computed tomography tracer for peripheral benzodiazepine receptors

Abstract Introduction [123 I]I-PK11195 is a high-affinity single photon emission computed tomography radiotracer for peripheral benzodiazepine receptors that has previously been used to measure activated microglia and to assess neuroinflammation in the living human brain. This study investigates the...

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Veröffentlicht in:	Nuclear medicine and biology 2008-07, Vol.35 (5), p.537-542
Hauptverfasser:	Pimlott, Sally L, Stevenson, Louise, Wyper, David J, Sutherland, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzodiazepine Chloramines Chromatography, High Pressure Liquid Drug Stability Indicators and Reagents Isoquinolines - chemical synthesis Isoquinolines - isolation & purification Isotope Labeling Microglial Neuroinflammation PK11195 Radiology Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - isolation & purification Radiosynthesis Receptors, GABA-A - metabolism Single photon emission computed tomography Spectrophotometry, Ultraviolet Tomography, Emission-Computed, Single-Photon Tosyl Compounds
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