Activity and DNA binding of new organoamidoplatinum (II) complexes

Two series of organoamidoplatinum (II) complexes were synthesized [Class 1, Pt(NRCH2)2L2 and Class 2, Pt(NRCH2CH2NR2')L(X)] and their antitumour activity examined by a range of in vitro, cellular and animal studies. All Class 1 compounds exhibited activity comparable to cisplatin in mouse leuke...

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Veröffentlicht in:	Investigational new drugs 1999-02, Vol.17 (1), p.1-15
Hauptverfasser:	TALARICO, T, PHILLIPS, D. R, DEACON, G. B, RAINONE, S, WEBSTER, L. K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Autoradiography Binding Sites Biological and medical sciences Cancer therapies Cell growth Chemotherapy Cisplatin - analogs & derivatives Cisplatin - metabolism Cross-Linking Reagents DNA Adducts - metabolism DNA Adducts - pharmacology Drug Screening Assays, Antitumor Drugs Drugs, Investigational - pharmacokinetics Drugs, Investigational - pharmacology Ethanol Female Humans In Vitro Techniques Leukemia Leukemia L1210 - drug therapy Leukemia L1210 - metabolism Ligands Medical research Medical sciences Mice Ovaries Pharmacology. Drug treatments Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism Tumors
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