Understanding the inflammatory response to cardiac surgery
The systemic inflammatory response to cardiac surgery is common, and resultant impairment of multiple organ function is generally mild or subclinical due to physiological reserve within organ systems. Unfortunately, the changing profile of patients referred for surgery suggests that the systemic inf...
Gespeichert in:
| Veröffentlicht in: | The surgeon (Edinburgh) 2008-06, Vol.6 (3), p.162-171 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 171 |
|---|---|
| container_issue | 3 |
| container_start_page | 162 |
| container_title | The surgeon (Edinburgh) |
| container_volume | 6 |
| creator | McGuinness, J Bouchier-Hayes, D Redmond, J.M |
| description | The systemic inflammatory response to cardiac surgery is common, and resultant impairment of multiple organ function is generally mild or subclinical due to physiological reserve within organ systems. Unfortunately, the changing profile of patients referred for surgery suggests that the systemic inflammatory response may prominently influence surgical outcome in the future. Older, co-morbid patients with more limited physiological reserve are being referred for complex lengthy procedures, and paediatric surgery has witnessed a shift to earlier complex primary correction or palliation involving long cardiopulmonary bypass times or a period of suboptimal organ perfusion using circulatory arrest or low flow cardiopulmonary bypass. Unique to cardiac surgery is the predictability of the inflammatory response, but prophylactic therapies have not translated into clinical benefit, which the preconditioning phenomenon may address. |
| doi_str_mv | 10.1016/S1479-666X(08)80113-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69265956</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1479666X08801138</els_id><sourcerecordid>69265956</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-ba80391f12fb57561daa986975dff2279adcc812e370fdfe830d7b0d064a25f23</originalsourceid><addsrcrecordid>eNqFkE1P3DAQQC1UBMvCT6DKqYJDYOzEjtNDUYWgICFxACRultceg7eJs7UTpPz7Zj_USr30NJc3bzSPkFMKFxSouHyiZVXnQojXM5DnEigtcrlHZqwEnnNZwicy-4MckqOUlgCMF8APyCGVXNKKFzPy9SVYjKnXwfrwlvXvmPngGt22uu_imEVMqy4kzPouMzpar02WhviGcTwm-043CU92c05ebm-er-_yh8cf99ffH3JTUtnnCy2hqKmjzC14xQW1WtdS1BW3zjFW1doaIynDogJnHcoCbLUAC6LUjDtWzMmXrXcVu18Dpl61PhlsGh2wG5ISNRO85mIC-RY0sUspolOr6FsdR0VBraOpTTS1LqJAqk00Jae9z7sDw6JF-3drV2kCrrYATm9-eIwqGY_BoPURTa9s5_974ts_BtP44I1ufuKIadkNMUwNFVWJKdhK1g6QG4MsfgPdfpHL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69265956</pqid></control><display><type>article</type><title>Understanding the inflammatory response to cardiac surgery</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>McGuinness, J ; Bouchier-Hayes, D ; Redmond, J.M</creator><creatorcontrib>McGuinness, J ; Bouchier-Hayes, D ; Redmond, J.M</creatorcontrib><description>The systemic inflammatory response to cardiac surgery is common, and resultant impairment of multiple organ function is generally mild or subclinical due to physiological reserve within organ systems. Unfortunately, the changing profile of patients referred for surgery suggests that the systemic inflammatory response may prominently influence surgical outcome in the future. Older, co-morbid patients with more limited physiological reserve are being referred for complex lengthy procedures, and paediatric surgery has witnessed a shift to earlier complex primary correction or palliation involving long cardiopulmonary bypass times or a period of suboptimal organ perfusion using circulatory arrest or low flow cardiopulmonary bypass. Unique to cardiac surgery is the predictability of the inflammatory response, but prophylactic therapies have not translated into clinical benefit, which the preconditioning phenomenon may address.</description><identifier>ISSN: 1479-666X</identifier><identifier>EISSN: 2405-5840</identifier><identifier>DOI: 10.1016/S1479-666X(08)80113-8</identifier><identifier>PMID: 18581753</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Cardiac Surgical Procedures - adverse effects ; endothelium ; Endothelium, Vascular - physiopathology ; Humans ; inflammation ; Inflammation Mediators - physiology ; inflammatory mediator ; Ischemic Preconditioning, Myocardial ; leucocyte ; preconditioning ; Surgery ; Systemic Inflammatory Response Syndrome - etiology ; Systemic Inflammatory Response Syndrome - prevention & control</subject><ispartof>The surgeon (Edinburgh), 2008-06, Vol.6 (3), p.162-171</ispartof><rights>Royal College of Surgeons of Edinburgh and Royal College of Surgeons in Ireland</rights><rights>2008 Royal College of Surgeons of Edinburgh and Royal College of Surgeons in Ireland</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-ba80391f12fb57561daa986975dff2279adcc812e370fdfe830d7b0d064a25f23</citedby><cites>FETCH-LOGICAL-c418t-ba80391f12fb57561daa986975dff2279adcc812e370fdfe830d7b0d064a25f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1479666X08801138$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18581753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McGuinness, J</creatorcontrib><creatorcontrib>Bouchier-Hayes, D</creatorcontrib><creatorcontrib>Redmond, J.M</creatorcontrib><title>Understanding the inflammatory response to cardiac surgery</title><title>The surgeon (Edinburgh)</title><addtitle>Surgeon</addtitle><description>The systemic inflammatory response to cardiac surgery is common, and resultant impairment of multiple organ function is generally mild or subclinical due to physiological reserve within organ systems. Unfortunately, the changing profile of patients referred for surgery suggests that the systemic inflammatory response may prominently influence surgical outcome in the future. Older, co-morbid patients with more limited physiological reserve are being referred for complex lengthy procedures, and paediatric surgery has witnessed a shift to earlier complex primary correction or palliation involving long cardiopulmonary bypass times or a period of suboptimal organ perfusion using circulatory arrest or low flow cardiopulmonary bypass. Unique to cardiac surgery is the predictability of the inflammatory response, but prophylactic therapies have not translated into clinical benefit, which the preconditioning phenomenon may address.</description><subject>Cardiac Surgical Procedures - adverse effects</subject><subject>endothelium</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Humans</subject><subject>inflammation</subject><subject>Inflammation Mediators - physiology</subject><subject>inflammatory mediator</subject><subject>Ischemic Preconditioning, Myocardial</subject><subject>leucocyte</subject><subject>preconditioning</subject><subject>Surgery</subject><subject>Systemic Inflammatory Response Syndrome - etiology</subject><subject>Systemic Inflammatory Response Syndrome - prevention & control</subject><issn>1479-666X</issn><issn>2405-5840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQQC1UBMvCT6DKqYJDYOzEjtNDUYWgICFxACRultceg7eJs7UTpPz7Zj_USr30NJc3bzSPkFMKFxSouHyiZVXnQojXM5DnEigtcrlHZqwEnnNZwicy-4MckqOUlgCMF8APyCGVXNKKFzPy9SVYjKnXwfrwlvXvmPngGt22uu_imEVMqy4kzPouMzpar02WhviGcTwm-043CU92c05ebm-er-_yh8cf99ffH3JTUtnnCy2hqKmjzC14xQW1WtdS1BW3zjFW1doaIynDogJnHcoCbLUAC6LUjDtWzMmXrXcVu18Dpl61PhlsGh2wG5ISNRO85mIC-RY0sUspolOr6FsdR0VBraOpTTS1LqJAqk00Jae9z7sDw6JF-3drV2kCrrYATm9-eIwqGY_BoPURTa9s5_974ts_BtP44I1ufuKIadkNMUwNFVWJKdhK1g6QG4MsfgPdfpHL</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>McGuinness, J</creator><creator>Bouchier-Hayes, D</creator><creator>Redmond, J.M</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080601</creationdate><title>Understanding the inflammatory response to cardiac surgery</title><author>McGuinness, J ; Bouchier-Hayes, D ; Redmond, J.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-ba80391f12fb57561daa986975dff2279adcc812e370fdfe830d7b0d064a25f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Cardiac Surgical Procedures - adverse effects</topic><topic>endothelium</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Humans</topic><topic>inflammation</topic><topic>Inflammation Mediators - physiology</topic><topic>inflammatory mediator</topic><topic>Ischemic Preconditioning, Myocardial</topic><topic>leucocyte</topic><topic>preconditioning</topic><topic>Surgery</topic><topic>Systemic Inflammatory Response Syndrome - etiology</topic><topic>Systemic Inflammatory Response Syndrome - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McGuinness, J</creatorcontrib><creatorcontrib>Bouchier-Hayes, D</creatorcontrib><creatorcontrib>Redmond, J.M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The surgeon (Edinburgh)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McGuinness, J</au><au>Bouchier-Hayes, D</au><au>Redmond, J.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Understanding the inflammatory response to cardiac surgery</atitle><jtitle>The surgeon (Edinburgh)</jtitle><addtitle>Surgeon</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>6</volume><issue>3</issue><spage>162</spage><epage>171</epage><pages>162-171</pages><issn>1479-666X</issn><eissn>2405-5840</eissn><abstract>The systemic inflammatory response to cardiac surgery is common, and resultant impairment of multiple organ function is generally mild or subclinical due to physiological reserve within organ systems. Unfortunately, the changing profile of patients referred for surgery suggests that the systemic inflammatory response may prominently influence surgical outcome in the future. Older, co-morbid patients with more limited physiological reserve are being referred for complex lengthy procedures, and paediatric surgery has witnessed a shift to earlier complex primary correction or palliation involving long cardiopulmonary bypass times or a period of suboptimal organ perfusion using circulatory arrest or low flow cardiopulmonary bypass. Unique to cardiac surgery is the predictability of the inflammatory response, but prophylactic therapies have not translated into clinical benefit, which the preconditioning phenomenon may address.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>18581753</pmid><doi>10.1016/S1479-666X(08)80113-8</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1479-666X |
| ispartof | The surgeon (Edinburgh), 2008-06, Vol.6 (3), p.162-171 |
| issn | 1479-666X 2405-5840 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69265956 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Cardiac Surgical Procedures - adverse effects endothelium Endothelium, Vascular - physiopathology Humans inflammation Inflammation Mediators - physiology inflammatory mediator Ischemic Preconditioning, Myocardial leucocyte preconditioning Surgery Systemic Inflammatory Response Syndrome - etiology Systemic Inflammatory Response Syndrome - prevention & control |
| title | Understanding the inflammatory response to cardiac surgery |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T14%3A24%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Understanding%20the%20inflammatory%20response%20to%20cardiac%20surgery&rft.jtitle=The%20surgeon%20(Edinburgh)&rft.au=McGuinness,%20J&rft.date=2008-06-01&rft.volume=6&rft.issue=3&rft.spage=162&rft.epage=171&rft.pages=162-171&rft.issn=1479-666X&rft.eissn=2405-5840&rft_id=info:doi/10.1016/S1479-666X(08)80113-8&rft_dat=%3Cproquest_cross%3E69265956%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69265956&rft_id=info:pmid/18581753&rft_els_id=1_s2_0_S1479666X08801138&rfr_iscdi=true |