Biphasic modulation of GABA(A) receptor binding by steroids suggests functional correlates

Neuroactive steroids and other positive modulators of GABA(A) receptors showed regional variation in both the efficacy and potency for modulation of [35S]TBPS binding to rat brain membrane homogenates, with biphasic concentration-dependence. GABA present in the binding assays prevented the enhanceme...

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Veröffentlicht in:	Neurochemical research 1999-11, Vol.24 (11), p.1363-1372
Hauptverfasser:	Srinivasan, S, Sapp, D W, Tobin, A J, Olsen, R W
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstanes - pharmacology Anesthetics - pharmacology Animals Azasteroids - pharmacology Baculoviridae - genetics Bicuculline - pharmacology Brain - metabolism Bridged Bicyclo Compounds, Heterocyclic - metabolism Cell Line Cell Membrane - metabolism GABA Antagonists - pharmacology gamma-Aminobutyric Acid - pharmacology Gene Expression Pregnanediones - pharmacology Rats Receptors, GABA-A - drug effects Receptors, GABA-A - genetics Receptors, GABA-A - metabolism Recombinant Proteins - metabolism Spodoptera Steroids - pharmacology Sulfur Radioisotopes
Online-Zugang:	Volltext
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