Activation of cerebellar granule cells GABA A receptors by guanidinoacetate

The extracellular concentration of guanidinoacetate (GAA) in the brain increases in guanidino acetate methyl transferase (GAMT) deficiency, an inherited disorder. We tested whether the levels which this substance can reach in the brain in GAMT deficiency are able to activate GABA A receptors in key...

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Veröffentlicht in:	Neuroscience 2008-03, Vol.152 (1), p.65-69
Hauptverfasser:	Cupello, A., Balestrino, M., Gatta, E., Pellistri, F., Siano, S., Robello, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured cerebellar granules Cerebellum - metabolism GABA A receptors GAMT deficiency Glycine - analogs & derivatives Glycine - metabolism guanidinoacetate Neurons - metabolism Patch-Clamp Techniques Rats Rats, Sprague-Dawley Receptors, GABA-A - metabolism tonic inhibition
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