Naive, Effector, and Memory CD8 T Cells in Protection Against Pulmonary Influenza Virus Infection: Homing Properties Rather Than Initial Frequencies Are Crucial

The goal of adoptive immunotherapy is to target a high number of persisting effector cells to the site of a virus infection or tumor. In this study, we compared the protective value of hemagglutinin peptide-specific CD8 T cells generated from the clone-4 TCR-transgenic mice, defined by different sta...

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Veröffentlicht in:	The Journal of immunology (1950) 1999-11, Vol.163 (10), p.5535-5543
Hauptverfasser:	Cerwenka, Adelheid, Morgan, Tammy M, Dutton, Richard W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer AIDS/HIV Animals Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Bronchoalveolar Lavage Fluid - virology CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell Movement - immunology Epitopes, T-Lymphocyte - immunology Hyaluronan Receptors - biosynthesis Immunologic Memory Influenza A virus - growth & development Influenza A virus - immunology influenza virus Interferon-gamma - biosynthesis Interphase - immunology Kinetics L-Selectin - biosynthesis Lung - virology Lymph Nodes - cytology Lymph Nodes - immunology Lymph Nodes - virology Lymphocyte Activation Lymphocyte Count Mice Mice, Inbred BALB C Mice, Transgenic Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - mortality Orthomyxoviridae Infections - prevention & control Orthomyxoviridae Infections - virology Spleen - cytology Spleen - immunology Spleen - virology Th1 Cells - immunology Th1 Cells - metabolism
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