Immune responses during helminth-malaria co-infection: a pilot study in Ghanaian school children
Malaria and helminth infections have a shared geographical distribution and therefore co-infections are frequent in tropical areas of the world. Human populations of helminth and malaria co-infection have shown contradictory results for the course of malarial infection and disease, possibly dependin...
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| Veröffentlicht in: | Parasitology 2008-06, Vol.135 (7), p.855-860 |
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| creator | HARTGERS, FRANCA C. OBENG, BENEDICTA B. BOAKYE, DANIEL YAZDANBAKHSH, MARIA |
| description | Malaria and helminth infections have a shared geographical distribution and therefore co-infections are frequent in tropical areas of the world. Human populations of helminth and malaria co-infection have shown contradictory results for the course of malarial infection and disease, possibly depending on the type of helminth studied, the intensity of helminth infection and the age of the study population. Although immunological studies might clarify the underlying mechanisms of protection or increased susceptibility, there are very few studies that have looked at immunological parameters in helminth and malaria co-infection. After discussing the available immunological data on co-infection, we describe a pilot study performed in Ghanaian school children where we compare anti-malarial responses in children living in an urban area, where the prevalence of helminth and Plasmodium falciparum infections was low, with that of children living in a rural area with high prevalence of helminth and Plasmodium falciparum infections. |
| doi_str_mv | 10.1017/S0031182008000401 |
| format | Article |
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Human populations of helminth and malaria co-infection have shown contradictory results for the course of malarial infection and disease, possibly depending on the type of helminth studied, the intensity of helminth infection and the age of the study population. Although immunological studies might clarify the underlying mechanisms of protection or increased susceptibility, there are very few studies that have looked at immunological parameters in helminth and malaria co-infection. After discussing the available immunological data on co-infection, we describe a pilot study performed in Ghanaian school children where we compare anti-malarial responses in children living in an urban area, where the prevalence of helminth and Plasmodium falciparum infections was low, with that of children living in a rural area with high prevalence of helminth and Plasmodium falciparum infections.</description><identifier>ISSN: 0031-1820</identifier><identifier>EISSN: 1469-8161</identifier><identifier>DOI: 10.1017/S0031182008000401</identifier><identifier>PMID: 18474122</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adolescent ; Animals ; Child ; Child, Preschool ; co-infection ; Comorbidity ; cytokines ; Female ; Geographical distribution ; Ghana - epidemiology ; helminth ; Helminthiasis - epidemiology ; Helminthiasis - immunology ; Human populations ; Humans ; immune responses ; Immunity, Cellular ; Malaria ; Malaria - epidemiology ; Malaria - immunology ; Malaria, Falciparum - epidemiology ; Malaria, Falciparum - immunology ; Male ; Pilot Projects ; Plasmodium falciparum ; Rural areas ; Urban areas ; Vector-borne diseases</subject><ispartof>Parasitology, 2008-06, Vol.135 (7), p.855-860</ispartof><rights>Copyright © 2008 Cambridge University Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-3cdd598c8b212aeed13d6264c3527cc0648f32b831b89841a8afcef3c65196ae3</citedby><cites>FETCH-LOGICAL-c439t-3cdd598c8b212aeed13d6264c3527cc0648f32b831b89841a8afcef3c65196ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0031182008000401/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,778,782,27907,27908,55611</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18474122$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HARTGERS, FRANCA C.</creatorcontrib><creatorcontrib>OBENG, BENEDICTA B.</creatorcontrib><creatorcontrib>BOAKYE, DANIEL</creatorcontrib><creatorcontrib>YAZDANBAKHSH, MARIA</creatorcontrib><title>Immune responses during helminth-malaria co-infection: a pilot study in Ghanaian school children</title><title>Parasitology</title><addtitle>Parasitology</addtitle><description>Malaria and helminth infections have a shared geographical distribution and therefore co-infections are frequent in tropical areas of the world. Human populations of helminth and malaria co-infection have shown contradictory results for the course of malarial infection and disease, possibly depending on the type of helminth studied, the intensity of helminth infection and the age of the study population. Although immunological studies might clarify the underlying mechanisms of protection or increased susceptibility, there are very few studies that have looked at immunological parameters in helminth and malaria co-infection. After discussing the available immunological data on co-infection, we describe a pilot study performed in Ghanaian school children where we compare anti-malarial responses in children living in an urban area, where the prevalence of helminth and Plasmodium falciparum infections was low, with that of children living in a rural area with high prevalence of helminth and Plasmodium falciparum infections.</description><subject>Adolescent</subject><subject>Animals</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>co-infection</subject><subject>Comorbidity</subject><subject>cytokines</subject><subject>Female</subject><subject>Geographical distribution</subject><subject>Ghana - epidemiology</subject><subject>helminth</subject><subject>Helminthiasis - epidemiology</subject><subject>Helminthiasis - immunology</subject><subject>Human populations</subject><subject>Humans</subject><subject>immune responses</subject><subject>Immunity, Cellular</subject><subject>Malaria</subject><subject>Malaria - epidemiology</subject><subject>Malaria - immunology</subject><subject>Malaria, Falciparum - epidemiology</subject><subject>Malaria, Falciparum - immunology</subject><subject>Male</subject><subject>Pilot Projects</subject><subject>Plasmodium falciparum</subject><subject>Rural areas</subject><subject>Urban areas</subject><subject>Vector-borne diseases</subject><issn>0031-1820</issn><issn>1469-8161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqFkUFv1DAQhS0EokvhB3BBFofeAh47sR1uqLTbilURAiRuxrGdxiWxFzuR2n-PV7uiEgj1NIf3zejNewi9BPIGCIi3XwhhAJISIgkhNYFHaAU1bysJHB6j1U6udvoRepbzTWE44_QpOgJZixooXaEfl9O0BIeTy9sYssvYLsmHazy4cfJhHqpJjzp5jU2sfOidmX0M77DGWz_GGed5sXfYB7wedNBeB5zNEOOIzeBHm1x4jp70eszuxWEeo2_nZ19PL6rNp_Xl6ftNZWrWzhUz1jatNLKjQLVzFpjllNeGNVQYQ3gte0Y7yaCTraxBS90b1zPDG2i5duwYnezvblP8tbg8q8ln48ZRBxeXrHhLOaEUHgQpESVNIQr4-i_wJi4plCcULSmDkI0sEOwhk2LOyfVqm_yk050ConYlqX9KKjuvDoeXbnL2fuPQSgGqPeDz7G7_6Dr9VFww0Si-_qw-XF183LTfG9UWnh1M6KlL3l67e6v_t_EbgL2qDw</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>HARTGERS, FRANCA C.</creator><creator>OBENG, BENEDICTA B.</creator><creator>BOAKYE, DANIEL</creator><creator>YAZDANBAKHSH, MARIA</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TM</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>20080601</creationdate><title>Immune responses during helminth-malaria co-infection: a pilot study in Ghanaian school children</title><author>HARTGERS, FRANCA C. ; OBENG, BENEDICTA B. ; BOAKYE, DANIEL ; YAZDANBAKHSH, MARIA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-3cdd598c8b212aeed13d6264c3527cc0648f32b831b89841a8afcef3c65196ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Animals</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>co-infection</topic><topic>Comorbidity</topic><topic>cytokines</topic><topic>Female</topic><topic>Geographical distribution</topic><topic>Ghana - 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Academic</collection><jtitle>Parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HARTGERS, FRANCA C.</au><au>OBENG, BENEDICTA B.</au><au>BOAKYE, DANIEL</au><au>YAZDANBAKHSH, MARIA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune responses during helminth-malaria co-infection: a pilot study in Ghanaian school children</atitle><jtitle>Parasitology</jtitle><addtitle>Parasitology</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>135</volume><issue>7</issue><spage>855</spage><epage>860</epage><pages>855-860</pages><issn>0031-1820</issn><eissn>1469-8161</eissn><abstract>Malaria and helminth infections have a shared geographical distribution and therefore co-infections are frequent in tropical areas of the world. Human populations of helminth and malaria co-infection have shown contradictory results for the course of malarial infection and disease, possibly depending on the type of helminth studied, the intensity of helminth infection and the age of the study population. Although immunological studies might clarify the underlying mechanisms of protection or increased susceptibility, there are very few studies that have looked at immunological parameters in helminth and malaria co-infection. After discussing the available immunological data on co-infection, we describe a pilot study performed in Ghanaian school children where we compare anti-malarial responses in children living in an urban area, where the prevalence of helminth and Plasmodium falciparum infections was low, with that of children living in a rural area with high prevalence of helminth and Plasmodium falciparum infections.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>18474122</pmid><doi>10.1017/S0031182008000401</doi><tpages>6</tpages></addata></record> |
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| ispartof | Parasitology, 2008-06, Vol.135 (7), p.855-860 |
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| subjects | Adolescent Animals Child Child, Preschool co-infection Comorbidity cytokines Female Geographical distribution Ghana - epidemiology helminth Helminthiasis - epidemiology Helminthiasis - immunology Human populations Humans immune responses Immunity, Cellular Malaria Malaria - epidemiology Malaria - immunology Malaria, Falciparum - epidemiology Malaria, Falciparum - immunology Male Pilot Projects Plasmodium falciparum Rural areas Urban areas Vector-borne diseases |
| title | Immune responses during helminth-malaria co-infection: a pilot study in Ghanaian school children |
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