Albumin, haemoglobin, BMI and cognitive performance in older adults
Objectives: to examine the relationships between serum albumin, haemoglobin and body mass index (BMI) with cognitive performance among community-living older adults. Method: design—population-based cross-sectional study; setting—local community in Southeast Region of Singapore; subjects—Chinese olde...
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| Veröffentlicht in: | Age and ageing 2008-07, Vol.37 (4), p.423-429 |
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| creator | Ng, Te-Pin Feng, Lei Niti, Mathew Yap, Keng Bee |
| description | Objectives: to examine the relationships between serum albumin, haemoglobin and body mass index (BMI) with cognitive performance among community-living older adults. Method: design—population-based cross-sectional study; setting—local community in Southeast Region of Singapore; subjects—Chinese older adults aged 55 and above (N = 2, 550); measurements—serum albumin, haemoglobin, BMI and Mini-Mental State Examination (MMSE). Results: in multivariable analyses controlling for gender, age, education and vascular risk factors, low albumin in the bottom quintile (OR 2.04; 95% CI 1.22–3.41) and low haemoglobin in the bottom quintile (OR 1.56; 95% CI 1.00–2.47) and low BMI with chronic comorbidity (OR 1.73; 95%CI 1.02–2.95) were independently associated with poor cognitive performance (MMSE ≤ 23). Among cognitively intact respondents (MMSE ≥ 24), albumin concentration showed a significant inverse linear relationship with MMSE scores (P for trend =0.002). Conclusion: low albumin, low haemoglobin and low BMI (in the presence of chronic comorbidity) are independently associated with poor cognitive performance in community-living older adults. |
| doi_str_mv | 10.1093/ageing/afn102 |
| format | Article |
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Method: design—population-based cross-sectional study; setting—local community in Southeast Region of Singapore; subjects—Chinese older adults aged 55 and above (N = 2, 550); measurements—serum albumin, haemoglobin, BMI and Mini-Mental State Examination (MMSE). Results: in multivariable analyses controlling for gender, age, education and vascular risk factors, low albumin in the bottom quintile (OR 2.04; 95% CI 1.22–3.41) and low haemoglobin in the bottom quintile (OR 1.56; 95% CI 1.00–2.47) and low BMI with chronic comorbidity (OR 1.73; 95%CI 1.02–2.95) were independently associated with poor cognitive performance (MMSE ≤ 23). Among cognitively intact respondents (MMSE ≥ 24), albumin concentration showed a significant inverse linear relationship with MMSE scores (P for trend =0.002). Conclusion: low albumin, low haemoglobin and low BMI (in the presence of chronic comorbidity) are independently associated with poor cognitive performance in community-living older adults.</description><identifier>ISSN: 0002-0729</identifier><identifier>EISSN: 1468-2834</identifier><identifier>DOI: 10.1093/ageing/afn102</identifier><identifier>PMID: 18495687</identifier><identifier>CODEN: AANGAH</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Aged ; Aged, 80 and over ; Albumin ; Anaemia ; Body Mass Index ; Chronic Disease ; Cognition ; Cognition & reasoning ; Cognition Disorders - epidemiology ; Cognition Disorders - metabolism ; Cognitive performance ; Comorbidity ; Cross-Sectional Studies ; Elderly ; Elderly people ; Evaluation ; Female ; Geriatric Assessment ; Haemoglobin ; Health aspects ; Hemoglobin ; Hemoglobins ; Hemoglobins - metabolism ; Humans ; Male ; Mental Status Schedule ; Middle Aged ; Multivariate Analysis ; Nutrition Assessment ; Older people ; Physiological aspects ; Plasma ; Prevalence ; Proteins ; Psychological aspects ; Risk Factors ; Serum Albumin - metabolism ; Weight</subject><ispartof>Age and ageing, 2008-07, Vol.37 (4), p.423-429</ispartof><rights>Copyright © The Author 2008. Published by Oxford University Press on behalf of the British Geriatrics Society. 2008</rights><rights>Copyright © The Author 2008. Published by Oxford University Press on behalf of the British Geriatrics Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-7732357996aa1151b2d4a26c303f27898ada66e6ec7defff35ee94da18d0f32a3</citedby><cites>FETCH-LOGICAL-c497t-7732357996aa1151b2d4a26c303f27898ada66e6ec7defff35ee94da18d0f32a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902,30976,30977</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18495687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ng, Te-Pin</creatorcontrib><creatorcontrib>Feng, Lei</creatorcontrib><creatorcontrib>Niti, Mathew</creatorcontrib><creatorcontrib>Yap, Keng Bee</creatorcontrib><title>Albumin, haemoglobin, BMI and cognitive performance in older adults</title><title>Age and ageing</title><addtitle>Age Ageing</addtitle><addtitle>Age Ageing</addtitle><description>Objectives: to examine the relationships between serum albumin, haemoglobin and body mass index (BMI) with cognitive performance among community-living older adults. Method: design—population-based cross-sectional study; setting—local community in Southeast Region of Singapore; subjects—Chinese older adults aged 55 and above (N = 2, 550); measurements—serum albumin, haemoglobin, BMI and Mini-Mental State Examination (MMSE). Results: in multivariable analyses controlling for gender, age, education and vascular risk factors, low albumin in the bottom quintile (OR 2.04; 95% CI 1.22–3.41) and low haemoglobin in the bottom quintile (OR 1.56; 95% CI 1.00–2.47) and low BMI with chronic comorbidity (OR 1.73; 95%CI 1.02–2.95) were independently associated with poor cognitive performance (MMSE ≤ 23). Among cognitively intact respondents (MMSE ≥ 24), albumin concentration showed a significant inverse linear relationship with MMSE scores (P for trend =0.002). Conclusion: low albumin, low haemoglobin and low BMI (in the presence of chronic comorbidity) are independently associated with poor cognitive performance in community-living older adults.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Albumin</subject><subject>Anaemia</subject><subject>Body Mass Index</subject><subject>Chronic Disease</subject><subject>Cognition</subject><subject>Cognition & reasoning</subject><subject>Cognition Disorders - epidemiology</subject><subject>Cognition Disorders - metabolism</subject><subject>Cognitive performance</subject><subject>Comorbidity</subject><subject>Cross-Sectional Studies</subject><subject>Elderly</subject><subject>Elderly people</subject><subject>Evaluation</subject><subject>Female</subject><subject>Geriatric Assessment</subject><subject>Haemoglobin</subject><subject>Health aspects</subject><subject>Hemoglobin</subject><subject>Hemoglobins</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Mental Status Schedule</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Nutrition Assessment</subject><subject>Older people</subject><subject>Physiological aspects</subject><subject>Plasma</subject><subject>Prevalence</subject><subject>Proteins</subject><subject>Psychological aspects</subject><subject>Risk Factors</subject><subject>Serum Albumin - metabolism</subject><subject>Weight</subject><issn>0002-0729</issn><issn>1468-2834</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqF0c2L1DAYBvAgijuuHr1K8SAerJuPNh_HcdTZhZH1oCJeQiZ9U7umyZi0ov-9GTq44GVP4YUfb56XB6GnBL8mWLEL08MQ-gvjAsH0HlqRhsuaStbcRyuMMa2xoOoMPcr5poykJfQhOiOyUS2XYoU2a7-fxyG8qr4bGGPv4_44vPlwVZnQVTb2YZiGX1AdILmYRhMsVEOoou8gVaab_ZQfowfO-AxPTu85-vz-3afNZb273l5t1rvaNkpMtRCMslYoxY0hJciedo2h3DLMHBVSSdMZzoGDFR0451gLoJrOENlhx6hh5-jFsveQ4s8Z8qTHIVvw3gSIc9Zc0VY1hN4JW0FLIsYKfP4fvIlzCuUITUnZxCU5onpBvfGgh2BjmOD3ZKP30IMuJ26u9ZpI2jJMCLn1NsWcEzh9SMNo0h9NsD52ppfO9NJZ8c9OIeb9CN2tPpVUwMsFxPlw567T30MuGf9hk35oLpho9eXXb_rtbqu-fNxSvWV_AcFMriY</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Ng, Te-Pin</creator><creator>Feng, Lei</creator><creator>Niti, Mathew</creator><creator>Yap, Keng Bee</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20080701</creationdate><title>Albumin, haemoglobin, BMI and cognitive performance in older adults</title><author>Ng, Te-Pin ; Feng, Lei ; Niti, Mathew ; Yap, Keng Bee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-7732357996aa1151b2d4a26c303f27898ada66e6ec7defff35ee94da18d0f32a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Albumin</topic><topic>Anaemia</topic><topic>Body Mass Index</topic><topic>Chronic Disease</topic><topic>Cognition</topic><topic>Cognition & reasoning</topic><topic>Cognition Disorders - epidemiology</topic><topic>Cognition Disorders - metabolism</topic><topic>Cognitive performance</topic><topic>Comorbidity</topic><topic>Cross-Sectional Studies</topic><topic>Elderly</topic><topic>Elderly people</topic><topic>Evaluation</topic><topic>Female</topic><topic>Geriatric Assessment</topic><topic>Haemoglobin</topic><topic>Health aspects</topic><topic>Hemoglobin</topic><topic>Hemoglobins</topic><topic>Hemoglobins - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Mental Status Schedule</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Nutrition Assessment</topic><topic>Older people</topic><topic>Physiological aspects</topic><topic>Plasma</topic><topic>Prevalence</topic><topic>Proteins</topic><topic>Psychological aspects</topic><topic>Risk Factors</topic><topic>Serum Albumin - metabolism</topic><topic>Weight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ng, Te-Pin</creatorcontrib><creatorcontrib>Feng, Lei</creatorcontrib><creatorcontrib>Niti, Mathew</creatorcontrib><creatorcontrib>Yap, Keng Bee</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Age and ageing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ng, Te-Pin</au><au>Feng, Lei</au><au>Niti, Mathew</au><au>Yap, Keng Bee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Albumin, haemoglobin, BMI and cognitive performance in older adults</atitle><jtitle>Age and ageing</jtitle><stitle>Age Ageing</stitle><addtitle>Age Ageing</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>37</volume><issue>4</issue><spage>423</spage><epage>429</epage><pages>423-429</pages><issn>0002-0729</issn><eissn>1468-2834</eissn><coden>AANGAH</coden><abstract>Objectives: to examine the relationships between serum albumin, haemoglobin and body mass index (BMI) with cognitive performance among community-living older adults. Method: design—population-based cross-sectional study; setting—local community in Southeast Region of Singapore; subjects—Chinese older adults aged 55 and above (N = 2, 550); measurements—serum albumin, haemoglobin, BMI and Mini-Mental State Examination (MMSE). Results: in multivariable analyses controlling for gender, age, education and vascular risk factors, low albumin in the bottom quintile (OR 2.04; 95% CI 1.22–3.41) and low haemoglobin in the bottom quintile (OR 1.56; 95% CI 1.00–2.47) and low BMI with chronic comorbidity (OR 1.73; 95%CI 1.02–2.95) were independently associated with poor cognitive performance (MMSE ≤ 23). Among cognitively intact respondents (MMSE ≥ 24), albumin concentration showed a significant inverse linear relationship with MMSE scores (P for trend =0.002). Conclusion: low albumin, low haemoglobin and low BMI (in the presence of chronic comorbidity) are independently associated with poor cognitive performance in community-living older adults.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>18495687</pmid><doi>10.1093/ageing/afn102</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Albumin Anaemia Body Mass Index Chronic Disease Cognition Cognition & reasoning Cognition Disorders - epidemiology Cognition Disorders - metabolism Cognitive performance Comorbidity Cross-Sectional Studies Elderly Elderly people Evaluation Female Geriatric Assessment Haemoglobin Health aspects Hemoglobin Hemoglobins Hemoglobins - metabolism Humans Male Mental Status Schedule Middle Aged Multivariate Analysis Nutrition Assessment Older people Physiological aspects Plasma Prevalence Proteins Psychological aspects Risk Factors Serum Albumin - metabolism Weight |
| title | Albumin, haemoglobin, BMI and cognitive performance in older adults |
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