Betaine protects urea-induced denaturation of myosin subfragment-1

We have demonstrated previously that urea inhibits the activity and alters the tertiary structure of skeletal muscle myosin in a biphasic manner. This was attributed to differential effects on its globular and filamentous portion. The inhibition of catalytic activity was counteracted by methylamines...

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Veröffentlicht in:	The FEBS journal 2008-07, Vol.275 (13), p.3388-3396
Hauptverfasser:	Ortiz-Costa, Susana, Sorenson, Martha M, Sola-Penna, Mauro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Betaine - chemistry Biochemistry Catalysis Catalytic Domain Chickens Enzymes Fluorescence Light methylamine Microscopy, Fluorescence muscle Musculoskeletal system myosin Myosin Subfragments - chemistry protection Protein Denaturation Protein Folding Protein Structure, Secondary Protein Structure, Tertiary Scattering, Radiation urea Urea - chemistry
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