Two-Photon Fluorescent Probes for Intracellular Free Zinc Ions in Living Tissue

Two-Photon Fluorescent Probes for Intracellular Free Zinc Ions in Living Tissue

The living image: The efficient two‐photon probes AZn1 and AZn2 (see picture for rat brain tissue) show 24‐ to 52‐fold two‐photon excited fluorescence enhancement in response to Zn2+. They can selectively detect intracellular free Zn2+ ions in live cells and in living tissues at a depth of 80–150 μm...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2008-06, Vol.47 (28), p.5167-5170
Hauptverfasser: Kim, Hwan Myung, Seo, Mun Sik, An, Myoung Jin, Hong, Jin Hee, Tian, Yu Shun, Choi, Joon Ho, Kwon, Ohyun, Lee, Kyoung J, Cho, Bong Rae
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Fluorescent Dyes
fluorescent probes
Hippocampus - chemistry
Hippocampus - cytology
imaging agents
living tissue
Microscopy - methods
Naphthalenes
Photons
Rats
two-photon microscopy
zinc
Zinc - analysis
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Beschreibung
Zusammenfassung:The living image: The efficient two‐photon probes AZn1 and AZn2 (see picture for rat brain tissue) show 24‐ to 52‐fold two‐photon excited fluorescence enhancement in response to Zn2+. They can selectively detect intracellular free Zn2+ ions in live cells and in living tissues at a depth of 80–150 μm without interference from other metal ions and the membrane‐bound probes.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200800929