Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma
Recent studies have reported increased podoplanin expression by cancer cells and stromal cells, but little is known about its expression and biological significance in adenocarcinoma of the lung. We examined podoplanin expression by both cancer cells and stromal cells in 177 consecutive lung adenoca...
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| Veröffentlicht in: | International journal of cancer 2008-09, Vol.123 (5), p.1053-1059 |
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| container_title | International journal of cancer |
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| creator | Kawase, Akikazu Ishii, Genichiro Nagai, Kanji Ito, Takeo Nagano, Tatsuya Murata, Yukinori Hishida, Tomoyuki Nishimura, Mitsuyo Yoshida, Junji Suzuki, Kazuya Ochiai, Atsushi |
| description | Recent studies have reported increased podoplanin expression by cancer cells and stromal cells, but little is known about its expression and biological significance in adenocarcinoma of the lung. We examined podoplanin expression by both cancer cells and stromal cells in 177 consecutive lung adenocarcinoma cases and analyzed relations between podoplanin expression and both clinicopathological factors and outcome. Podoplanin expression was observed on the apical membrane of the cancer cells in only 9 of the 177 (5.1%) cases. By contrast, cancer‐associated fibroblasts (CAFs) were found to express podoplanin in 54 cases (30.5%). Podoplanin (+) CAFs were found only in invasive adenocarcinoma and none were found in noninvasive adenocarcinoma. Conventional prognostic factors were significantly correlated with podoplanin expression by CAFs. The univariate analyses and log‐rank test showed that podoplanin expression was significantly associated with shorter survival time (p < 0.001 and p < 0.001, respectively). We divided the cases into 3 groups according grade based on the proportion of CAFs expressing podoplanin [a grade 0 group (n = 123), a grade 1 group (n = 36) and a grade 2 group (n = 18)]. The result showed that conventional prognostic factors were significantly correlated with the grade of podoplanin expression by CAFs. Furthermore, the grade 2 group tended to have a shorter survival time than the grade 1 group (p = 0.092). The results of this study highlight the importance of podoplanin expression by CAFs and provide new insights into the biology of the cancer microenvironment in adenocarcinoma of the lung. © 2008 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ijc.23611 |
| format | Article |
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We examined podoplanin expression by both cancer cells and stromal cells in 177 consecutive lung adenocarcinoma cases and analyzed relations between podoplanin expression and both clinicopathological factors and outcome. Podoplanin expression was observed on the apical membrane of the cancer cells in only 9 of the 177 (5.1%) cases. By contrast, cancer‐associated fibroblasts (CAFs) were found to express podoplanin in 54 cases (30.5%). Podoplanin (+) CAFs were found only in invasive adenocarcinoma and none were found in noninvasive adenocarcinoma. Conventional prognostic factors were significantly correlated with podoplanin expression by CAFs. The univariate analyses and log‐rank test showed that podoplanin expression was significantly associated with shorter survival time (p < 0.001 and p < 0.001, respectively). We divided the cases into 3 groups according grade based on the proportion of CAFs expressing podoplanin [a grade 0 group (n = 123), a grade 1 group (n = 36) and a grade 2 group (n = 18)]. The result showed that conventional prognostic factors were significantly correlated with the grade of podoplanin expression by CAFs. Furthermore, the grade 2 group tended to have a shorter survival time than the grade 1 group (p = 0.092). The results of this study highlight the importance of podoplanin expression by CAFs and provide new insights into the biology of the cancer microenvironment in adenocarcinoma of the lung. © 2008 Wiley‐Liss, Inc.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.23611</identifier><identifier>PMID: 18546264</identifier><identifier>CODEN: IJCNAW</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenocarcinoma - chemistry ; Adenocarcinoma - pathology ; Aged ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Blotting, Western ; cancer‐associated fibroblasts ; Female ; Fibroblasts - chemistry ; Fluorescent Antibody Technique ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; lung adeno‐carcinoma ; Lung Neoplasms - chemistry ; Lung Neoplasms - pathology ; Lymphatic Metastasis ; Male ; Medical sciences ; Membrane Glycoproteins - analysis ; Microscopy, Confocal ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Pneumology ; podoplanin ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Stromal Cells - chemistry ; Survival Analysis ; Tumors ; Tumors of the respiratory system and mediastinum</subject><ispartof>International journal of cancer, 2008-09, Vol.123 (5), p.1053-1059</ispartof><rights>Copyright © 2008 Wiley‐Liss, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4541-5c38cb47a47aa89550901580817c5ed8b42b323776af60bfa17792e4842ecd443</citedby><cites>FETCH-LOGICAL-c4541-5c38cb47a47aa89550901580817c5ed8b42b323776af60bfa17792e4842ecd443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.23611$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.23611$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20516459$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18546264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawase, Akikazu</creatorcontrib><creatorcontrib>Ishii, Genichiro</creatorcontrib><creatorcontrib>Nagai, Kanji</creatorcontrib><creatorcontrib>Ito, Takeo</creatorcontrib><creatorcontrib>Nagano, Tatsuya</creatorcontrib><creatorcontrib>Murata, Yukinori</creatorcontrib><creatorcontrib>Hishida, Tomoyuki</creatorcontrib><creatorcontrib>Nishimura, Mitsuyo</creatorcontrib><creatorcontrib>Yoshida, Junji</creatorcontrib><creatorcontrib>Suzuki, Kazuya</creatorcontrib><creatorcontrib>Ochiai, Atsushi</creatorcontrib><title>Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>Recent studies have reported increased podoplanin expression by cancer cells and stromal cells, but little is known about its expression and biological significance in adenocarcinoma of the lung. We examined podoplanin expression by both cancer cells and stromal cells in 177 consecutive lung adenocarcinoma cases and analyzed relations between podoplanin expression and both clinicopathological factors and outcome. Podoplanin expression was observed on the apical membrane of the cancer cells in only 9 of the 177 (5.1%) cases. By contrast, cancer‐associated fibroblasts (CAFs) were found to express podoplanin in 54 cases (30.5%). Podoplanin (+) CAFs were found only in invasive adenocarcinoma and none were found in noninvasive adenocarcinoma. Conventional prognostic factors were significantly correlated with podoplanin expression by CAFs. The univariate analyses and log‐rank test showed that podoplanin expression was significantly associated with shorter survival time (p < 0.001 and p < 0.001, respectively). We divided the cases into 3 groups according grade based on the proportion of CAFs expressing podoplanin [a grade 0 group (n = 123), a grade 1 group (n = 36) and a grade 2 group (n = 18)]. The result showed that conventional prognostic factors were significantly correlated with the grade of podoplanin expression by CAFs. Furthermore, the grade 2 group tended to have a shorter survival time than the grade 1 group (p = 0.092). The results of this study highlight the importance of podoplanin expression by CAFs and provide new insights into the biology of the cancer microenvironment in adenocarcinoma of the lung. © 2008 Wiley‐Liss, Inc.</description><subject>Adenocarcinoma - chemistry</subject><subject>Adenocarcinoma - pathology</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Blotting, Western</subject><subject>cancer‐associated fibroblasts</subject><subject>Female</subject><subject>Fibroblasts - chemistry</subject><subject>Fluorescent Antibody Technique</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>lung adeno‐carcinoma</subject><subject>Lung Neoplasms - chemistry</subject><subject>Lung Neoplasms - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - analysis</subject><subject>Microscopy, Confocal</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Pneumology</subject><subject>podoplanin</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Stromal Cells - chemistry</subject><subject>Survival Analysis</subject><subject>Tumors</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LAzEQhoMotlYP_gHJRcHD2kw2H7tHKX5UBD3oeclmsyVlu6mZFu2_N7VFT0JgEuZh3slDyDmwG2CMj_3c3vBcARyQIbBSZ4yDPCTD1GOZhlwNyAninDEAycQxGUAhheJKDIl7DU1Ydqb3PXVfy-gQfehpvaHW9NZFahCD9WblGtr6Ooa6M7hCmsjG2-0lhJheYdYH9EhDS7t1P6OmcX2wJlrfh4U5JUet6dCd7euIvN_fvU0es-eXh-nk9jmzQgrIpM0LWwtt0jFFKSUrGciCFaCtdE1RC17nPNdamVaxujWgdcmdKAR3thEiH5Gr3dy00Mfa4apaeLSuS_9zYY2VKrkErcoEXu9AGwNidG21jH5h4qYCVm2dVslp9eM0sRf7oet64Zo_ci8xAZd7wKA1XRuTOY-_HGcSlJDb0PGO-_Sd2_yfWE2fJrvob-mDjkc</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>Kawase, Akikazu</creator><creator>Ishii, Genichiro</creator><creator>Nagai, Kanji</creator><creator>Ito, Takeo</creator><creator>Nagano, Tatsuya</creator><creator>Murata, Yukinori</creator><creator>Hishida, Tomoyuki</creator><creator>Nishimura, Mitsuyo</creator><creator>Yoshida, Junji</creator><creator>Suzuki, Kazuya</creator><creator>Ochiai, Atsushi</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080901</creationdate><title>Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma</title><author>Kawase, Akikazu ; Ishii, Genichiro ; Nagai, Kanji ; Ito, Takeo ; Nagano, Tatsuya ; Murata, Yukinori ; Hishida, Tomoyuki ; Nishimura, Mitsuyo ; Yoshida, Junji ; Suzuki, Kazuya ; Ochiai, Atsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4541-5c38cb47a47aa89550901580817c5ed8b42b323776af60bfa17792e4842ecd443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adenocarcinoma - chemistry</topic><topic>Adenocarcinoma - pathology</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Blotting, Western</topic><topic>cancer‐associated fibroblasts</topic><topic>Female</topic><topic>Fibroblasts - chemistry</topic><topic>Fluorescent Antibody Technique</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>lung adeno‐carcinoma</topic><topic>Lung Neoplasms - chemistry</topic><topic>Lung Neoplasms - pathology</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins - analysis</topic><topic>Microscopy, Confocal</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Pneumology</topic><topic>podoplanin</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Stromal Cells - chemistry</topic><topic>Survival Analysis</topic><topic>Tumors</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawase, Akikazu</creatorcontrib><creatorcontrib>Ishii, Genichiro</creatorcontrib><creatorcontrib>Nagai, Kanji</creatorcontrib><creatorcontrib>Ito, Takeo</creatorcontrib><creatorcontrib>Nagano, Tatsuya</creatorcontrib><creatorcontrib>Murata, Yukinori</creatorcontrib><creatorcontrib>Hishida, Tomoyuki</creatorcontrib><creatorcontrib>Nishimura, Mitsuyo</creatorcontrib><creatorcontrib>Yoshida, Junji</creatorcontrib><creatorcontrib>Suzuki, Kazuya</creatorcontrib><creatorcontrib>Ochiai, Atsushi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawase, Akikazu</au><au>Ishii, Genichiro</au><au>Nagai, Kanji</au><au>Ito, Takeo</au><au>Nagano, Tatsuya</au><au>Murata, Yukinori</au><au>Hishida, Tomoyuki</au><au>Nishimura, Mitsuyo</au><au>Yoshida, Junji</au><au>Suzuki, Kazuya</au><au>Ochiai, Atsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>123</volume><issue>5</issue><spage>1053</spage><epage>1059</epage><pages>1053-1059</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><coden>IJCNAW</coden><abstract>Recent studies have reported increased podoplanin expression by cancer cells and stromal cells, but little is known about its expression and biological significance in adenocarcinoma of the lung. We examined podoplanin expression by both cancer cells and stromal cells in 177 consecutive lung adenocarcinoma cases and analyzed relations between podoplanin expression and both clinicopathological factors and outcome. Podoplanin expression was observed on the apical membrane of the cancer cells in only 9 of the 177 (5.1%) cases. By contrast, cancer‐associated fibroblasts (CAFs) were found to express podoplanin in 54 cases (30.5%). Podoplanin (+) CAFs were found only in invasive adenocarcinoma and none were found in noninvasive adenocarcinoma. Conventional prognostic factors were significantly correlated with podoplanin expression by CAFs. The univariate analyses and log‐rank test showed that podoplanin expression was significantly associated with shorter survival time (p < 0.001 and p < 0.001, respectively). We divided the cases into 3 groups according grade based on the proportion of CAFs expressing podoplanin [a grade 0 group (n = 123), a grade 1 group (n = 36) and a grade 2 group (n = 18)]. The result showed that conventional prognostic factors were significantly correlated with the grade of podoplanin expression by CAFs. Furthermore, the grade 2 group tended to have a shorter survival time than the grade 1 group (p = 0.092). The results of this study highlight the importance of podoplanin expression by CAFs and provide new insights into the biology of the cancer microenvironment in adenocarcinoma of the lung. © 2008 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>18546264</pmid><doi>10.1002/ijc.23611</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma - chemistry Adenocarcinoma - pathology Aged Biological and medical sciences Biomarkers, Tumor - analysis Blotting, Western cancer‐associated fibroblasts Female Fibroblasts - chemistry Fluorescent Antibody Technique Gene Expression Regulation, Neoplastic Humans Immunohistochemistry lung adeno‐carcinoma Lung Neoplasms - chemistry Lung Neoplasms - pathology Lymphatic Metastasis Male Medical sciences Membrane Glycoproteins - analysis Microscopy, Confocal Middle Aged Neoplasm Invasiveness Neoplasm Staging Pneumology podoplanin Predictive Value of Tests Prognosis Retrospective Studies Stromal Cells - chemistry Survival Analysis Tumors Tumors of the respiratory system and mediastinum |
| title | Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma |
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