The docking properties of SHIP2 influence both JIP1 tyrosine phosphorylation and JNK activity

SHIP2 (SH2-containing inositol polyphosphate 5-phosphatase 2) is an ubiquitously expressed phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3) 5-phosphatase which contains various motifs susceptible to mediate protein–protein interaction. In cell models, evidence has been provided that SHIP...

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Veröffentlicht in:	Cellular signalling 2008-08, Vol.20 (8), p.1432-1441
Hauptverfasser:	Xie, Jingwei, Onnockx, Sheela, Vandenbroere, Isabelle, Degraef, Chantal, Erneux, Christophe, Pirson, Isabelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Abl Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - metabolism Animals Binding Sites Cercopithecus aethiops COS Cells Humans JIP1 JNK MAP Kinase Signaling System Mitogen-Activated Protein Kinase 8 - metabolism Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases Phosphoric Monoester Hydrolases - metabolism Phosphorylation SHIP2 Src Tyrosine - metabolism
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