STAUROSPORINE-INDUCED CELL DEATH IN TETRAHYMENA THERMOPHILA HAS MIXED CHARACTERISTICS OF BOTH APOPTOTIC AND AUTOPHAGIC DEGENERATION

Staurosporine blocks signal transduction associated with cell survival, proliferation and chemosensory behaviour in the ciliated protozoan, Tetrahymena thermophila. Staurosporine inhibits cell proliferation and in vivo protein phosphorylation induced by phorbol ester. It also reduces the in vitro ph...

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Veröffentlicht in:	Cell biology international 1998-01, Vol.22 (7-8), p.591-598
Hauptverfasser:	CHRISTENSEN, SØREN T., CHEMNITZ, JOHN, STRAARUP, ELLEN M., KRISTIANSEN, KARSTEN, WHEATLEY, DENYS N., RASMUSSEN, LEIF
Format:	Artikel
Sprache:	eng
Schlagworte:	actinomycin D Animals apoptosis Apoptosis - physiology autophagic degeneration Autophagy - drug effects Autophagy - physiology death Enzyme Inhibitors - pharmacology programmed cell death proliferation signalling staurosporine Staurosporine - pharmacology survival Tetrahymena thermophila Tetrahymena thermophila - drug effects Tetrahymena thermophila - ultrastructure
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