Tissue inhibitor of metalloproteinase-1 mRNA production and protein secretion are induced by interleukin-1β in 3T3-L1 adipocytes

The adipokine tissue inhibitor of metalloproteinase (TIMP)-1 is upregulated when weight is gained and promotes adipose tissue development. In the present study, the effect of insulin resistance-inducing and proinflammatory interleukin (IL)-1β on TIMP-1 gene expression and secretion was investigated...

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Veröffentlicht in:	Journal of endocrinology 2008-07, Vol.198 (1), p.169-174
Hauptverfasser:	Weise, Sebastian, Kralisch, Susan, Sommer, Grit, Lossner, Ulrike, Bluher, Matthias, Stumvoll, Michael, Fasshauer, Mathias
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Animals Biological and medical sciences Cell Differentiation Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Interleukin-1beta - pharmacology Interleukin-6 - pharmacology Mice Regular papers RNA, Messenger - analysis Tissue Inhibitor of Metalloproteinase-1 - genetics Tissue Inhibitor of Metalloproteinase-1 - secretion Tissue Inhibitor of Metalloproteinase-2 - genetics Tumor Necrosis Factor-alpha - pharmacology Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue
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