Differences in Cytochrome P450 and Nuclear Receptor mRNA Levels in Liver and Small Intestines between SD and DA Rats

This study aimed to clarify the differences in mRNA levels of cytochrome P450 (CYP) isoforms and nuclear receptors between Dark Agouti (DA) and Sprague-Dawley (SD) rats which are animal models for poor metabolizers and extensive metabolizers for CYP2D6, respectively. Using liver and small intestine...

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Veröffentlicht in:	DRUG METABOLISM AND PHARMACOKINETICS 2008-01, Vol.23 (3), p.196-206
Hauptverfasser:	Kawase, Atsushi, Fujii, Akiyuki, Negoro, Makiko, Akai, Ryosuke, Ishikubo, Miki, Komura, Hiroshi, Iwaki, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Chromatography, High Pressure Liquid Cytochrome P-450 Enzyme System - genetics cytochrome P450 DA rat Female Intestine, Small - enzymology Intestine, Small - metabolism Liver - enzymology Liver - metabolism Male Microsomes - enzymology Microsomes - metabolism Molecular Sequence Data nuclear receptor Organ Specificity Protein Isoforms Rats Rats, Inbred Strains Rats, Sprague-Dawley Receptors, Cytoplasmic and Nuclear - genetics RNA, Messenger - genetics SD rat Species Specificity strain difference
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