Effect of chronic furosemide administration on acid-base balance in patients with chronic hypercapnic respiratory failure
We quantitatively analyzed the effect of long-term administration of oral furosemide on the PaCO2 - H+ relationship in patients with chronic hypercapnic respiratory failure. In this study we measured arterial blood gases of eighteen outpatients (mean duration of visits, 7.6 years; mean rise of PaCO2...
Gespeichert in:
| Veröffentlicht in: | Tokai journal of experimental and clinical medicine 1998-10, Vol.23 (4), p.193-197 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 197 |
|---|---|
| container_issue | 4 |
| container_start_page | 193 |
| container_title | Tokai journal of experimental and clinical medicine |
| container_volume | 23 |
| creator | Urano, T Kondo, T Oh-Hori, K I Kumagai, M Miyairi, A Ohta, Y |
| description | We quantitatively analyzed the effect of long-term administration of oral furosemide on the PaCO2 - H+ relationship in patients with chronic hypercapnic respiratory failure. In this study we measured arterial blood gases of eighteen outpatients (mean duration of visits, 7.6 years; mean rise of PaCO2, 15.4 mmHg). We obtained linear regression lines for PaCO2 - H+, and determined their Y-axis intercepts and slopes. The results indicated that an increase in the administered dose of furosemide decreased linearly the Y-axis intercept of the regression line [(Y-intercept) = - 6.9(dose of furosemide) + 30.9, r = 0.81], and increased linearly the slope of the regression line [(slope) = 0.094(dose of furosemide) + 0.22, r = 0.74]. Thus, the regression line of the PaCO2 - H+ relationship moved downward and became steeper at higher doses of furosemide. The regression lines for each dose of furosemide crossed at a PaCO2 of 75 mmHg. We concluded that there is a mutual interaction between the renal and respiratory mechanisms for acid-base balance in chronic hypercapnia and the effect of furosemide on the PaCO2 - H+ relationship is negligible in severe hypercapnia. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_69247049</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69247049</sourcerecordid><originalsourceid>FETCH-LOGICAL-n151t-2e866137164cfdc042b9c6219bd84e93effd9e3525498a55334e2230938a641b3</originalsourceid><addsrcrecordid>eNo9kE1LxDAQhnNQ3HX1L0hO3gr5bnOUZf2ABS96LmkyYSNtU5MU6b-34iq8MAPz8DC8F2hLeCMrQojcoOucPwgRtRL1FdpQwqWWlGzRcvAebMHRY3tKcQwW-znFDENwgI0bwhhySaaEOOI1xgZXdSYD7kxvRgs4jHhazzCWjL9COf17TssEyZrpZ0-Qp7BaYlqwN6GfE9ygS2_6DLfnuUPvj4e3_XN1fH162T8cq5FKWioGjVKU11QJ650lgnXaKkZ15xoBmoP3TgOXTArdGCk5F8AYJ5o3Rgna8R26__VOKX7OkEs7hGyhX7-HOOdWaSZqIvQK3p3BuRvAtVMKg0lL-1cW_wbxuma_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69247049</pqid></control><display><type>article</type><title>Effect of chronic furosemide administration on acid-base balance in patients with chronic hypercapnic respiratory failure</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Urano, T ; Kondo, T ; Oh-Hori, K I ; Kumagai, M ; Miyairi, A ; Ohta, Y</creator><creatorcontrib>Urano, T ; Kondo, T ; Oh-Hori, K I ; Kumagai, M ; Miyairi, A ; Ohta, Y</creatorcontrib><description>We quantitatively analyzed the effect of long-term administration of oral furosemide on the PaCO2 - H+ relationship in patients with chronic hypercapnic respiratory failure. In this study we measured arterial blood gases of eighteen outpatients (mean duration of visits, 7.6 years; mean rise of PaCO2, 15.4 mmHg). We obtained linear regression lines for PaCO2 - H+, and determined their Y-axis intercepts and slopes. The results indicated that an increase in the administered dose of furosemide decreased linearly the Y-axis intercept of the regression line [(Y-intercept) = - 6.9(dose of furosemide) + 30.9, r = 0.81], and increased linearly the slope of the regression line [(slope) = 0.094(dose of furosemide) + 0.22, r = 0.74]. Thus, the regression line of the PaCO2 - H+ relationship moved downward and became steeper at higher doses of furosemide. The regression lines for each dose of furosemide crossed at a PaCO2 of 75 mmHg. We concluded that there is a mutual interaction between the renal and respiratory mechanisms for acid-base balance in chronic hypercapnia and the effect of furosemide on the PaCO2 - H+ relationship is negligible in severe hypercapnia.</description><identifier>ISSN: 0385-0005</identifier><identifier>PMID: 10359510</identifier><language>eng</language><publisher>Japan</publisher><subject>Acid-Base Equilibrium - drug effects ; Aged ; Blood Gas Analysis ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Furosemide - administration & dosage ; Furosemide - therapeutic use ; Humans ; Hypercapnia - drug therapy ; Longitudinal Studies ; Middle Aged ; Pulmonary Gas Exchange ; Respiratory Insufficiency - drug therapy ; Time Factors</subject><ispartof>Tokai journal of experimental and clinical medicine, 1998-10, Vol.23 (4), p.193-197</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10359510$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Urano, T</creatorcontrib><creatorcontrib>Kondo, T</creatorcontrib><creatorcontrib>Oh-Hori, K I</creatorcontrib><creatorcontrib>Kumagai, M</creatorcontrib><creatorcontrib>Miyairi, A</creatorcontrib><creatorcontrib>Ohta, Y</creatorcontrib><title>Effect of chronic furosemide administration on acid-base balance in patients with chronic hypercapnic respiratory failure</title><title>Tokai journal of experimental and clinical medicine</title><addtitle>Tokai J Exp Clin Med</addtitle><description>We quantitatively analyzed the effect of long-term administration of oral furosemide on the PaCO2 - H+ relationship in patients with chronic hypercapnic respiratory failure. In this study we measured arterial blood gases of eighteen outpatients (mean duration of visits, 7.6 years; mean rise of PaCO2, 15.4 mmHg). We obtained linear regression lines for PaCO2 - H+, and determined their Y-axis intercepts and slopes. The results indicated that an increase in the administered dose of furosemide decreased linearly the Y-axis intercept of the regression line [(Y-intercept) = - 6.9(dose of furosemide) + 30.9, r = 0.81], and increased linearly the slope of the regression line [(slope) = 0.094(dose of furosemide) + 0.22, r = 0.74]. Thus, the regression line of the PaCO2 - H+ relationship moved downward and became steeper at higher doses of furosemide. The regression lines for each dose of furosemide crossed at a PaCO2 of 75 mmHg. We concluded that there is a mutual interaction between the renal and respiratory mechanisms for acid-base balance in chronic hypercapnia and the effect of furosemide on the PaCO2 - H+ relationship is negligible in severe hypercapnia.</description><subject>Acid-Base Equilibrium - drug effects</subject><subject>Aged</subject><subject>Blood Gas Analysis</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Schedule</subject><subject>Furosemide - administration & dosage</subject><subject>Furosemide - therapeutic use</subject><subject>Humans</subject><subject>Hypercapnia - drug therapy</subject><subject>Longitudinal Studies</subject><subject>Middle Aged</subject><subject>Pulmonary Gas Exchange</subject><subject>Respiratory Insufficiency - drug therapy</subject><subject>Time Factors</subject><issn>0385-0005</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LxDAQhnNQ3HX1L0hO3gr5bnOUZf2ABS96LmkyYSNtU5MU6b-34iq8MAPz8DC8F2hLeCMrQojcoOucPwgRtRL1FdpQwqWWlGzRcvAebMHRY3tKcQwW-znFDENwgI0bwhhySaaEOOI1xgZXdSYD7kxvRgs4jHhazzCWjL9COf17TssEyZrpZ0-Qp7BaYlqwN6GfE9ygS2_6DLfnuUPvj4e3_XN1fH162T8cq5FKWioGjVKU11QJ650lgnXaKkZ15xoBmoP3TgOXTArdGCk5F8AYJ5o3Rgna8R26__VOKX7OkEs7hGyhX7-HOOdWaSZqIvQK3p3BuRvAtVMKg0lL-1cW_wbxuma_</recordid><startdate>199810</startdate><enddate>199810</enddate><creator>Urano, T</creator><creator>Kondo, T</creator><creator>Oh-Hori, K I</creator><creator>Kumagai, M</creator><creator>Miyairi, A</creator><creator>Ohta, Y</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199810</creationdate><title>Effect of chronic furosemide administration on acid-base balance in patients with chronic hypercapnic respiratory failure</title><author>Urano, T ; Kondo, T ; Oh-Hori, K I ; Kumagai, M ; Miyairi, A ; Ohta, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-n151t-2e866137164cfdc042b9c6219bd84e93effd9e3525498a55334e2230938a641b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acid-Base Equilibrium - drug effects</topic><topic>Aged</topic><topic>Blood Gas Analysis</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Administration Schedule</topic><topic>Furosemide - administration & dosage</topic><topic>Furosemide - therapeutic use</topic><topic>Humans</topic><topic>Hypercapnia - drug therapy</topic><topic>Longitudinal Studies</topic><topic>Middle Aged</topic><topic>Pulmonary Gas Exchange</topic><topic>Respiratory Insufficiency - drug therapy</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Urano, T</creatorcontrib><creatorcontrib>Kondo, T</creatorcontrib><creatorcontrib>Oh-Hori, K I</creatorcontrib><creatorcontrib>Kumagai, M</creatorcontrib><creatorcontrib>Miyairi, A</creatorcontrib><creatorcontrib>Ohta, Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Tokai journal of experimental and clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Urano, T</au><au>Kondo, T</au><au>Oh-Hori, K I</au><au>Kumagai, M</au><au>Miyairi, A</au><au>Ohta, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of chronic furosemide administration on acid-base balance in patients with chronic hypercapnic respiratory failure</atitle><jtitle>Tokai journal of experimental and clinical medicine</jtitle><addtitle>Tokai J Exp Clin Med</addtitle><date>1998-10</date><risdate>1998</risdate><volume>23</volume><issue>4</issue><spage>193</spage><epage>197</epage><pages>193-197</pages><issn>0385-0005</issn><abstract>We quantitatively analyzed the effect of long-term administration of oral furosemide on the PaCO2 - H+ relationship in patients with chronic hypercapnic respiratory failure. In this study we measured arterial blood gases of eighteen outpatients (mean duration of visits, 7.6 years; mean rise of PaCO2, 15.4 mmHg). We obtained linear regression lines for PaCO2 - H+, and determined their Y-axis intercepts and slopes. The results indicated that an increase in the administered dose of furosemide decreased linearly the Y-axis intercept of the regression line [(Y-intercept) = - 6.9(dose of furosemide) + 30.9, r = 0.81], and increased linearly the slope of the regression line [(slope) = 0.094(dose of furosemide) + 0.22, r = 0.74]. Thus, the regression line of the PaCO2 - H+ relationship moved downward and became steeper at higher doses of furosemide. The regression lines for each dose of furosemide crossed at a PaCO2 of 75 mmHg. We concluded that there is a mutual interaction between the renal and respiratory mechanisms for acid-base balance in chronic hypercapnia and the effect of furosemide on the PaCO2 - H+ relationship is negligible in severe hypercapnia.</abstract><cop>Japan</cop><pmid>10359510</pmid><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0385-0005 |
| ispartof | Tokai journal of experimental and clinical medicine, 1998-10, Vol.23 (4), p.193-197 |
| issn | 0385-0005 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69247049 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acid-Base Equilibrium - drug effects Aged Blood Gas Analysis Dose-Response Relationship, Drug Drug Administration Schedule Furosemide - administration & dosage Furosemide - therapeutic use Humans Hypercapnia - drug therapy Longitudinal Studies Middle Aged Pulmonary Gas Exchange Respiratory Insufficiency - drug therapy Time Factors |
| title | Effect of chronic furosemide administration on acid-base balance in patients with chronic hypercapnic respiratory failure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T18%3A35%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20chronic%20furosemide%20administration%20on%20acid-base%20balance%20in%20patients%20with%20chronic%20hypercapnic%20respiratory%20failure&rft.jtitle=Tokai%20journal%20of%20experimental%20and%20clinical%20medicine&rft.au=Urano,%20T&rft.date=1998-10&rft.volume=23&rft.issue=4&rft.spage=193&rft.epage=197&rft.pages=193-197&rft.issn=0385-0005&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E69247049%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69247049&rft_id=info:pmid/10359510&rfr_iscdi=true |