Supra-and Extrasellar Pituitary Microadenoma as a Cause of Cushing's Disease
There has been accumulating evidence that pituitary adenomas which cause Cushing's disease are located not only in sella turcica but also in various extrasellar and intracranial regions. We describe a case of Cushing's disease caused by a supra- and extrasellar ACTH-producing microadenoma,...
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Veröffentlicht in: | ENDOCRINE JOURNAL 1998, Vol.45(5), pp.631-636 |
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creator | MURAKAMI, NORIHIKO FURUTO-KATO, SUMIKO FUJISAWA, ICHIRO OHYAMA, KENJI NAKAO, SATOSHI KUWAYAMA, AKIO KAGEYAMA, NAOKI |
description | There has been accumulating evidence that pituitary adenomas which cause Cushing's disease are located not only in sella turcica but also in various extrasellar and intracranial regions. We describe a case of Cushing's disease caused by a supra- and extrasellar ACTH-producing microadenoma, which originated in the anterior pituitary and extended upward without connecting to the stalk. The pituitary microadenoma was identified and removed by transsphenoidal microsurgery. After the surgery the patient experienced complete remission. This type of pituitary microadenoma is considered to be rare, but in order to accomplish successful surgical treatment, it is necessary to consider that pituitary adenomas which cause Cushing's disease may be located in such an unusual position. |
doi_str_mv | 10.1507/endocrj.45.631 |
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We describe a case of Cushing's disease caused by a supra- and extrasellar ACTH-producing microadenoma, which originated in the anterior pituitary and extended upward without connecting to the stalk. The pituitary microadenoma was identified and removed by transsphenoidal microsurgery. After the surgery the patient experienced complete remission. This type of pituitary microadenoma is considered to be rare, but in order to accomplish successful surgical treatment, it is necessary to consider that pituitary adenomas which cause Cushing's disease may be located in such an unusual position.</description><identifier>ISSN: 0918-8959</identifier><identifier>EISSN: 1348-4540</identifier><identifier>DOI: 10.1507/endocrj.45.631</identifier><identifier>PMID: 10395243</identifier><language>eng</language><publisher>Japan: The Japan Endocrine Society</publisher><subject>Adenoma - complications ; Adenoma - diagnosis ; Adenoma - surgery ; Adrenocorticotropic Hormone - analysis ; Adult ; Cushing Syndrome - blood ; Cushing Syndrome - etiology ; Cushing's disease ; Female ; Humans ; Immunohistochemistry ; Magnetic Resonance Imaging ; Microsurgery - methods ; Neoplasm Invasiveness ; Pituitary Gland, Anterior ; Pituitary Neoplasms - complications ; Pituitary Neoplasms - diagnosis ; Pituitary Neoplasms - surgery ; Reoperation ; Supra-and extrasellar pituitary microadenoma</subject><ispartof>Endocrine Journal, 1998, Vol.45(5), pp.631-636</ispartof><rights>The Japan Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10395243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MURAKAMI, NORIHIKO</creatorcontrib><creatorcontrib>FURUTO-KATO, SUMIKO</creatorcontrib><creatorcontrib>FUJISAWA, ICHIRO</creatorcontrib><creatorcontrib>OHYAMA, KENJI</creatorcontrib><creatorcontrib>NAKAO, SATOSHI</creatorcontrib><creatorcontrib>KUWAYAMA, AKIO</creatorcontrib><creatorcontrib>KAGEYAMA, NAOKI</creatorcontrib><creatorcontrib>Department of Neurosurgery</creatorcontrib><creatorcontrib>Kishiwada City Hospital</creatorcontrib><creatorcontrib>Department of Radiology</creatorcontrib><creatorcontrib>Department of Internal Medicine</creatorcontrib><creatorcontrib>Nagoya National Hospital</creatorcontrib><title>Supra-and Extrasellar Pituitary Microadenoma as a Cause of Cushing's Disease</title><title>ENDOCRINE JOURNAL</title><addtitle>Endocr J</addtitle><description>There has been accumulating evidence that pituitary adenomas which cause Cushing's disease are located not only in sella turcica but also in various extrasellar and intracranial regions. We describe a case of Cushing's disease caused by a supra- and extrasellar ACTH-producing microadenoma, which originated in the anterior pituitary and extended upward without connecting to the stalk. The pituitary microadenoma was identified and removed by transsphenoidal microsurgery. After the surgery the patient experienced complete remission. This type of pituitary microadenoma is considered to be rare, but in order to accomplish successful surgical treatment, it is necessary to consider that pituitary adenomas which cause Cushing's disease may be located in such an unusual position.</description><subject>Adenoma - complications</subject><subject>Adenoma - diagnosis</subject><subject>Adenoma - surgery</subject><subject>Adrenocorticotropic Hormone - analysis</subject><subject>Adult</subject><subject>Cushing Syndrome - blood</subject><subject>Cushing Syndrome - etiology</subject><subject>Cushing's disease</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Magnetic Resonance Imaging</subject><subject>Microsurgery - methods</subject><subject>Neoplasm Invasiveness</subject><subject>Pituitary Gland, Anterior</subject><subject>Pituitary Neoplasms - complications</subject><subject>Pituitary Neoplasms - diagnosis</subject><subject>Pituitary Neoplasms - surgery</subject><subject>Reoperation</subject><subject>Supra-and extrasellar pituitary microadenoma</subject><issn>0918-8959</issn><issn>1348-4540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc9PwyAUx4nR6Pxx9Wg46amTlgctRzPnNJnRRD2TN2BK07UT2kT_e5mbXt5L4MMHvg9CznM2zgUrr11rOxPqMYix5PkeGeUcqgwEsH0yYiqvskoJdUSOY6wZ41wAPyRHOeNKFMBHZP4yrANm2Fo6_eoDRtc0GOiz7wffY_imj96EDq1ruxVSjBTpBIfoaLekkyF--Pb9KtJbH106ekoOlthEd7brJ-Ttbvo6uc_mT7OHyc08q7nkfSYYK0q3sAglr7AUBUMncmBWgIKC8wU4l9YsSLRWKVlIziUYU8rSwCKFOCGXW-86dJ-Di71e-Wg2L29dN0QtVQGyApHAix04LFbO6nXwqxRK_-VPwN0WSLveYNO1jW-drrshtCmBNp_yd8I6V6rSjIFgYtM0S9PeFClVqaoqiWZbUR17fHf_N2HovWmc3v1T0nANQott2Uj-CPOBIWH8B1bVi9A</recordid><startdate>19981001</startdate><enddate>19981001</enddate><creator>MURAKAMI, NORIHIKO</creator><creator>FURUTO-KATO, SUMIKO</creator><creator>FUJISAWA, ICHIRO</creator><creator>OHYAMA, KENJI</creator><creator>NAKAO, SATOSHI</creator><creator>KUWAYAMA, AKIO</creator><creator>KAGEYAMA, NAOKI</creator><general>The Japan Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19981001</creationdate><title>Supra-and Extrasellar Pituitary Microadenoma as a Cause of Cushing's Disease</title><author>MURAKAMI, NORIHIKO ; FURUTO-KATO, SUMIKO ; FUJISAWA, ICHIRO ; OHYAMA, KENJI ; NAKAO, SATOSHI ; KUWAYAMA, AKIO ; KAGEYAMA, NAOKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j363t-50027ebda4738a7520ae5140d5494233b4ee20ad46add996263364cc767c4b033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adenoma - complications</topic><topic>Adenoma - diagnosis</topic><topic>Adenoma - surgery</topic><topic>Adrenocorticotropic Hormone - analysis</topic><topic>Adult</topic><topic>Cushing Syndrome - blood</topic><topic>Cushing Syndrome - etiology</topic><topic>Cushing's disease</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Magnetic Resonance Imaging</topic><topic>Microsurgery - methods</topic><topic>Neoplasm Invasiveness</topic><topic>Pituitary Gland, Anterior</topic><topic>Pituitary Neoplasms - complications</topic><topic>Pituitary Neoplasms - diagnosis</topic><topic>Pituitary Neoplasms - surgery</topic><topic>Reoperation</topic><topic>Supra-and extrasellar pituitary microadenoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MURAKAMI, NORIHIKO</creatorcontrib><creatorcontrib>FURUTO-KATO, SUMIKO</creatorcontrib><creatorcontrib>FUJISAWA, ICHIRO</creatorcontrib><creatorcontrib>OHYAMA, KENJI</creatorcontrib><creatorcontrib>NAKAO, SATOSHI</creatorcontrib><creatorcontrib>KUWAYAMA, AKIO</creatorcontrib><creatorcontrib>KAGEYAMA, NAOKI</creatorcontrib><creatorcontrib>Department of Neurosurgery</creatorcontrib><creatorcontrib>Kishiwada City Hospital</creatorcontrib><creatorcontrib>Department of Radiology</creatorcontrib><creatorcontrib>Department of Internal Medicine</creatorcontrib><creatorcontrib>Nagoya National Hospital</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>ENDOCRINE JOURNAL</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MURAKAMI, NORIHIKO</au><au>FURUTO-KATO, SUMIKO</au><au>FUJISAWA, ICHIRO</au><au>OHYAMA, KENJI</au><au>NAKAO, SATOSHI</au><au>KUWAYAMA, AKIO</au><au>KAGEYAMA, NAOKI</au><aucorp>Department of Neurosurgery</aucorp><aucorp>Kishiwada City Hospital</aucorp><aucorp>Department of Radiology</aucorp><aucorp>Department of Internal Medicine</aucorp><aucorp>Nagoya National Hospital</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Supra-and Extrasellar Pituitary Microadenoma as a Cause of Cushing's Disease</atitle><jtitle>ENDOCRINE JOURNAL</jtitle><addtitle>Endocr J</addtitle><date>1998-10-01</date><risdate>1998</risdate><volume>45</volume><issue>5</issue><spage>631</spage><epage>636</epage><pages>631-636</pages><issn>0918-8959</issn><eissn>1348-4540</eissn><abstract>There has been accumulating evidence that pituitary adenomas which cause Cushing's disease are located not only in sella turcica but also in various extrasellar and intracranial regions. We describe a case of Cushing's disease caused by a supra- and extrasellar ACTH-producing microadenoma, which originated in the anterior pituitary and extended upward without connecting to the stalk. The pituitary microadenoma was identified and removed by transsphenoidal microsurgery. After the surgery the patient experienced complete remission. This type of pituitary microadenoma is considered to be rare, but in order to accomplish successful surgical treatment, it is necessary to consider that pituitary adenomas which cause Cushing's disease may be located in such an unusual position.</abstract><cop>Japan</cop><pub>The Japan Endocrine Society</pub><pmid>10395243</pmid><doi>10.1507/endocrj.45.631</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
subjects | Adenoma - complications Adenoma - diagnosis Adenoma - surgery Adrenocorticotropic Hormone - analysis Adult Cushing Syndrome - blood Cushing Syndrome - etiology Cushing's disease Female Humans Immunohistochemistry Magnetic Resonance Imaging Microsurgery - methods Neoplasm Invasiveness Pituitary Gland, Anterior Pituitary Neoplasms - complications Pituitary Neoplasms - diagnosis Pituitary Neoplasms - surgery Reoperation Supra-and extrasellar pituitary microadenoma |
title | Supra-and Extrasellar Pituitary Microadenoma as a Cause of Cushing's Disease |
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