Impact of COPD on Outcome Among Patients With Complicated Peptic Ulcer
Background: COPD is associated with an increased risk of peptic ulcer disease, but limited data exist on whether COPD influences short-term mortality among patients with bleeding and a perforated peptic ulcer. We examined the association between COPD and 30-day mortality following bleeding and perfo...
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| Veröffentlicht in: | Chest 2008-06, Vol.133 (6), p.1360-1366 |
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| creator | CHRISTENSEN, Steffen THOMSEN, Reimar W TØRRING, Marie Louise RIIS, Anders NØRGAARD, Mette SØRENSEN, Henrik T |
| description | Background: COPD is associated with an increased risk of peptic ulcer disease, but limited data exist on whether COPD influences short-term
mortality among patients with bleeding and a perforated peptic ulcer. We examined the association between COPD and 30-day
mortality following bleeding and perforation of a peptic ulcer.
Methods: We identified all patients who had been hospitalized with a first-time diagnosis of peptic ulcer perforation (n = 2,033)
or bleeding (n = 7,486) in northern Denmark between 1991 and 2004. Information on COPD, comorbidities, and filled prescriptions
was obtained from medical databases. Mortality was ascertained using the Danish Civil Registration System. We computed the
cumulative 30-day mortality rates for ulcer patients with COPD and for other ulcer patients, and used regression analysis
to obtain the 30-day mortality rate ratios (MRRs), controlling for potential confounding factors.
Results: Among patients who were hospitalized with perforated peptic ulcers, 218 (10.7%) had previously been hospitalized with COPD.
The 30-day mortality rate was 44.0% among perforated ulcer patients with COPD vs 25.5% among other ulcer patients (adjusted
MRR, 1.48; 95% confidence interval [CI], 1.18 to 1.85). Among patients hospitalized with a bleeding peptic ulcer, 759 (10.1%)
had previously been hospitalized with COPD. The 30-day mortality rate was 16.5% among bleeding peptic ulcer patients with
COPD vs 10.8% among other ulcer patients (adjusted MRR, 1.38; 95% CI, 1.14 to 1.68). The use of oral glucocorticoids among
COPD patients was associated with higher MRRs for both perforated and bleeding peptic ulcers.
Conclusions: COPD substantially increased 30-day mortality among patients with bleeding and perforated peptic ulcers.
cohort study
COPD
mortality
peptic ulcer hemorrhage
peptic ulcer perforation
prognosis |
| doi_str_mv | 10.1378/chest.07-2543 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69245664</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69245664</sourcerecordid><originalsourceid>FETCH-LOGICAL-c362t-fc14c39e409be39575e03e17273c0827ec3f252eaf70cf9ec3e45ade74cadaef3</originalsourceid><addsrcrecordid>eNpF0MFPHCEUBnBi2uhqe-y14dLexgKPGWaOZq2ticnuQeORIPtwMcwwBSam_32xu2lP8JJfPngfIZ84u-Sg-m92j7lcMtWIVsIJWfEBeAP1_o6sGOOigW4QZ-Q85xdWZz50p-SM9wCD6rsVubkdZ2MLjY6uN9trGie6WYqNI9KrMU7PdGuKx6lk-ujLnq7jOAdvTcEd3eJcvKUPwWL6QN47EzJ-PJ4X5OHm-_36Z3O3-XG7vrprLHSiNM5yaWFAyYYnhKFVLTJAroQCy3qh0IITrUDjFLNuqCPK1uxQSWt2Bh1ckK-H3DnFX0vdXI8-WwzBTBiXrOuusu06WWFzgDbFnBM6PSc_mvRbc6bfitN_i9NM6bfiqv98DF6eRtz918emKvhyBCZbE1wyk_X5nxNMyr7a6tjB7f3z_tUn1Hk0IdRYODz5Epc0mcABdFd_0jH4A9jCh3w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69245664</pqid></control><display><type>article</type><title>Impact of COPD on Outcome Among Patients With Complicated Peptic Ulcer</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>CHRISTENSEN, Steffen ; THOMSEN, Reimar W ; TØRRING, Marie Louise ; RIIS, Anders ; NØRGAARD, Mette ; SØRENSEN, Henrik T</creator><creatorcontrib>CHRISTENSEN, Steffen ; THOMSEN, Reimar W ; TØRRING, Marie Louise ; RIIS, Anders ; NØRGAARD, Mette ; SØRENSEN, Henrik T</creatorcontrib><description>Background: COPD is associated with an increased risk of peptic ulcer disease, but limited data exist on whether COPD influences short-term
mortality among patients with bleeding and a perforated peptic ulcer. We examined the association between COPD and 30-day
mortality following bleeding and perforation of a peptic ulcer.
Methods: We identified all patients who had been hospitalized with a first-time diagnosis of peptic ulcer perforation (n = 2,033)
or bleeding (n = 7,486) in northern Denmark between 1991 and 2004. Information on COPD, comorbidities, and filled prescriptions
was obtained from medical databases. Mortality was ascertained using the Danish Civil Registration System. We computed the
cumulative 30-day mortality rates for ulcer patients with COPD and for other ulcer patients, and used regression analysis
to obtain the 30-day mortality rate ratios (MRRs), controlling for potential confounding factors.
Results: Among patients who were hospitalized with perforated peptic ulcers, 218 (10.7%) had previously been hospitalized with COPD.
The 30-day mortality rate was 44.0% among perforated ulcer patients with COPD vs 25.5% among other ulcer patients (adjusted
MRR, 1.48; 95% confidence interval [CI], 1.18 to 1.85). Among patients hospitalized with a bleeding peptic ulcer, 759 (10.1%)
had previously been hospitalized with COPD. The 30-day mortality rate was 16.5% among bleeding peptic ulcer patients with
COPD vs 10.8% among other ulcer patients (adjusted MRR, 1.38; 95% CI, 1.14 to 1.68). The use of oral glucocorticoids among
COPD patients was associated with higher MRRs for both perforated and bleeding peptic ulcers.
Conclusions: COPD substantially increased 30-day mortality among patients with bleeding and perforated peptic ulcers.
cohort study
COPD
mortality
peptic ulcer hemorrhage
peptic ulcer perforation
prognosis</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.07-2543</identifier><identifier>PMID: 18339786</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: American College of Chest Physicians</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Cardiology. Vascular system ; Chronic obstructive pulmonary disease, asthma ; Confidence Intervals ; Denmark - epidemiology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Glucocorticoids - therapeutic use ; Humans ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Peptic Ulcer Hemorrhage - complications ; Peptic Ulcer Hemorrhage - epidemiology ; Peptic Ulcer Perforation - complications ; Peptic Ulcer Perforation - epidemiology ; Pneumology ; Population Surveillance - methods ; Pulmonary Disease, Chronic Obstructive - classification ; Pulmonary Disease, Chronic Obstructive - complications ; Pulmonary Disease, Chronic Obstructive - mortality ; Registries ; Severity of Illness Index ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><ispartof>Chest, 2008-06, Vol.133 (6), p.1360-1366</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-fc14c39e409be39575e03e17273c0827ec3f252eaf70cf9ec3e45ade74cadaef3</citedby><cites>FETCH-LOGICAL-c362t-fc14c39e409be39575e03e17273c0827ec3f252eaf70cf9ec3e45ade74cadaef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20448833$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18339786$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHRISTENSEN, Steffen</creatorcontrib><creatorcontrib>THOMSEN, Reimar W</creatorcontrib><creatorcontrib>TØRRING, Marie Louise</creatorcontrib><creatorcontrib>RIIS, Anders</creatorcontrib><creatorcontrib>NØRGAARD, Mette</creatorcontrib><creatorcontrib>SØRENSEN, Henrik T</creatorcontrib><title>Impact of COPD on Outcome Among Patients With Complicated Peptic Ulcer</title><title>Chest</title><addtitle>Chest</addtitle><description>Background: COPD is associated with an increased risk of peptic ulcer disease, but limited data exist on whether COPD influences short-term
mortality among patients with bleeding and a perforated peptic ulcer. We examined the association between COPD and 30-day
mortality following bleeding and perforation of a peptic ulcer.
Methods: We identified all patients who had been hospitalized with a first-time diagnosis of peptic ulcer perforation (n = 2,033)
or bleeding (n = 7,486) in northern Denmark between 1991 and 2004. Information on COPD, comorbidities, and filled prescriptions
was obtained from medical databases. Mortality was ascertained using the Danish Civil Registration System. We computed the
cumulative 30-day mortality rates for ulcer patients with COPD and for other ulcer patients, and used regression analysis
to obtain the 30-day mortality rate ratios (MRRs), controlling for potential confounding factors.
Results: Among patients who were hospitalized with perforated peptic ulcers, 218 (10.7%) had previously been hospitalized with COPD.
The 30-day mortality rate was 44.0% among perforated ulcer patients with COPD vs 25.5% among other ulcer patients (adjusted
MRR, 1.48; 95% confidence interval [CI], 1.18 to 1.85). Among patients hospitalized with a bleeding peptic ulcer, 759 (10.1%)
had previously been hospitalized with COPD. The 30-day mortality rate was 16.5% among bleeding peptic ulcer patients with
COPD vs 10.8% among other ulcer patients (adjusted MRR, 1.38; 95% CI, 1.14 to 1.68). The use of oral glucocorticoids among
COPD patients was associated with higher MRRs for both perforated and bleeding peptic ulcers.
Conclusions: COPD substantially increased 30-day mortality among patients with bleeding and perforated peptic ulcers.
cohort study
COPD
mortality
peptic ulcer hemorrhage
peptic ulcer perforation
prognosis</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Confidence Intervals</subject><subject>Denmark - epidemiology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Peptic Ulcer Hemorrhage - complications</subject><subject>Peptic Ulcer Hemorrhage - epidemiology</subject><subject>Peptic Ulcer Perforation - complications</subject><subject>Peptic Ulcer Perforation - epidemiology</subject><subject>Pneumology</subject><subject>Population Surveillance - methods</subject><subject>Pulmonary Disease, Chronic Obstructive - classification</subject><subject>Pulmonary Disease, Chronic Obstructive - complications</subject><subject>Pulmonary Disease, Chronic Obstructive - mortality</subject><subject>Registries</subject><subject>Severity of Illness Index</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0MFPHCEUBnBi2uhqe-y14dLexgKPGWaOZq2ticnuQeORIPtwMcwwBSam_32xu2lP8JJfPngfIZ84u-Sg-m92j7lcMtWIVsIJWfEBeAP1_o6sGOOigW4QZ-Q85xdWZz50p-SM9wCD6rsVubkdZ2MLjY6uN9trGie6WYqNI9KrMU7PdGuKx6lk-ujLnq7jOAdvTcEd3eJcvKUPwWL6QN47EzJ-PJ4X5OHm-_36Z3O3-XG7vrprLHSiNM5yaWFAyYYnhKFVLTJAroQCy3qh0IITrUDjFLNuqCPK1uxQSWt2Bh1ckK-H3DnFX0vdXI8-WwzBTBiXrOuusu06WWFzgDbFnBM6PSc_mvRbc6bfitN_i9NM6bfiqv98DF6eRtz918emKvhyBCZbE1wyk_X5nxNMyr7a6tjB7f3z_tUn1Hk0IdRYODz5Epc0mcABdFd_0jH4A9jCh3w</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>CHRISTENSEN, Steffen</creator><creator>THOMSEN, Reimar W</creator><creator>TØRRING, Marie Louise</creator><creator>RIIS, Anders</creator><creator>NØRGAARD, Mette</creator><creator>SØRENSEN, Henrik T</creator><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080601</creationdate><title>Impact of COPD on Outcome Among Patients With Complicated Peptic Ulcer</title><author>CHRISTENSEN, Steffen ; THOMSEN, Reimar W ; TØRRING, Marie Louise ; RIIS, Anders ; NØRGAARD, Mette ; SØRENSEN, Henrik T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-fc14c39e409be39575e03e17273c0827ec3f252eaf70cf9ec3e45ade74cadaef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Confidence Intervals</topic><topic>Denmark - epidemiology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Peptic Ulcer Hemorrhage - complications</topic><topic>Peptic Ulcer Hemorrhage - epidemiology</topic><topic>Peptic Ulcer Perforation - complications</topic><topic>Peptic Ulcer Perforation - epidemiology</topic><topic>Pneumology</topic><topic>Population Surveillance - methods</topic><topic>Pulmonary Disease, Chronic Obstructive - classification</topic><topic>Pulmonary Disease, Chronic Obstructive - complications</topic><topic>Pulmonary Disease, Chronic Obstructive - mortality</topic><topic>Registries</topic><topic>Severity of Illness Index</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHRISTENSEN, Steffen</creatorcontrib><creatorcontrib>THOMSEN, Reimar W</creatorcontrib><creatorcontrib>TØRRING, Marie Louise</creatorcontrib><creatorcontrib>RIIS, Anders</creatorcontrib><creatorcontrib>NØRGAARD, Mette</creatorcontrib><creatorcontrib>SØRENSEN, Henrik T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHRISTENSEN, Steffen</au><au>THOMSEN, Reimar W</au><au>TØRRING, Marie Louise</au><au>RIIS, Anders</au><au>NØRGAARD, Mette</au><au>SØRENSEN, Henrik T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of COPD on Outcome Among Patients With Complicated Peptic Ulcer</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>133</volume><issue>6</issue><spage>1360</spage><epage>1366</epage><pages>1360-1366</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>Background: COPD is associated with an increased risk of peptic ulcer disease, but limited data exist on whether COPD influences short-term
mortality among patients with bleeding and a perforated peptic ulcer. We examined the association between COPD and 30-day
mortality following bleeding and perforation of a peptic ulcer.
Methods: We identified all patients who had been hospitalized with a first-time diagnosis of peptic ulcer perforation (n = 2,033)
or bleeding (n = 7,486) in northern Denmark between 1991 and 2004. Information on COPD, comorbidities, and filled prescriptions
was obtained from medical databases. Mortality was ascertained using the Danish Civil Registration System. We computed the
cumulative 30-day mortality rates for ulcer patients with COPD and for other ulcer patients, and used regression analysis
to obtain the 30-day mortality rate ratios (MRRs), controlling for potential confounding factors.
Results: Among patients who were hospitalized with perforated peptic ulcers, 218 (10.7%) had previously been hospitalized with COPD.
The 30-day mortality rate was 44.0% among perforated ulcer patients with COPD vs 25.5% among other ulcer patients (adjusted
MRR, 1.48; 95% confidence interval [CI], 1.18 to 1.85). Among patients hospitalized with a bleeding peptic ulcer, 759 (10.1%)
had previously been hospitalized with COPD. The 30-day mortality rate was 16.5% among bleeding peptic ulcer patients with
COPD vs 10.8% among other ulcer patients (adjusted MRR, 1.38; 95% CI, 1.14 to 1.68). The use of oral glucocorticoids among
COPD patients was associated with higher MRRs for both perforated and bleeding peptic ulcers.
Conclusions: COPD substantially increased 30-day mortality among patients with bleeding and perforated peptic ulcers.
cohort study
COPD
mortality
peptic ulcer hemorrhage
peptic ulcer perforation
prognosis</abstract><cop>Northbrook, IL</cop><pub>American College of Chest Physicians</pub><pmid>18339786</pmid><doi>10.1378/chest.07-2543</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Chest, 2008-06, Vol.133 (6), p.1360-1366 |
| issn | 0012-3692 1931-3543 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69245664 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Biological and medical sciences Cardiology. Vascular system Chronic obstructive pulmonary disease, asthma Confidence Intervals Denmark - epidemiology Female Gastroenterology. Liver. Pancreas. Abdomen Glucocorticoids - therapeutic use Humans Male Medical sciences Middle Aged Other diseases. Semiology Peptic Ulcer Hemorrhage - complications Peptic Ulcer Hemorrhage - epidemiology Peptic Ulcer Perforation - complications Peptic Ulcer Perforation - epidemiology Pneumology Population Surveillance - methods Pulmonary Disease, Chronic Obstructive - classification Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - mortality Registries Severity of Illness Index Stomach. Duodenum. Small intestine. Colon. Rectum. Anus |
| title | Impact of COPD on Outcome Among Patients With Complicated Peptic Ulcer |
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