Serum levels of soluble form of receptor for advanced glycation end products (sRAGE) are positively associated with circulating AGEs and soluble form of VCAM-1 in patients with type 2 diabetes
We have recently found that soluble form of receptor for advanced glycation end products (sRAGE) levels are positively associated with inflammatory biomarkers and the presence of coronary artery disease (CAD) in type 2 diabetic patients. Since advanced glycation end products (AGEs) up-regulate RAGE...
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| Veröffentlicht in: | Microvascular research 2008-05, Vol.76 (1), p.52-56 |
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| creator | Nakamura, Kazuo Yamagishi, Sho-ichi Adachi, Hisashi Matsui, Takanori Kurita-Nakamura, Yayoi Takeuchi, Masayoshi Inoue, Hiroyoshi Imaizumi, Tsutomu |
| description | We have recently found that soluble form of receptor for advanced glycation end products (sRAGE) levels are positively associated with inflammatory biomarkers and the presence of coronary artery disease (CAD) in type 2 diabetic patients. Since advanced glycation end products (AGEs) up-regulate RAGE expression and endogenous sRAGE could be generated from the cleavage of cell surface RAGE, it is conceivable that sRAGE is positively associated with circulating AGEs levels in diabetes. In this study, we examined whether sRAGE were correlated to circulating levels of AGEs and soluble forms of vascular cell adhesion molecule-1 (sVCAM-1) and intercellular adhesion molecule-1 (sICAM-1) in patients with type 2 diabetes. Eighty-two Japanese type 2 diabetic patients underwent a complete history and physical examination, determination of blood chemistries, sRAGE, AGEs, sVCAM-1 and sICAM-1. Multiple regression analysis revealed that serum levels of AGEs and sVCAM-1 were independently correlated with sRAGE. This study demonstrated that serum levels of sRAGE were positively associated with circulating AGEs and sVCAM-1 levels in type 2 diabetic patients. Our present observations suggest sRAGE level may be elevated in response to circulating AGEs, thus being a novel marker of vascular injury in patients with type 2 diabetes. |
| doi_str_mv | 10.1016/j.mvr.2007.09.004 |
| format | Article |
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Since advanced glycation end products (AGEs) up-regulate RAGE expression and endogenous sRAGE could be generated from the cleavage of cell surface RAGE, it is conceivable that sRAGE is positively associated with circulating AGEs levels in diabetes. In this study, we examined whether sRAGE were correlated to circulating levels of AGEs and soluble forms of vascular cell adhesion molecule-1 (sVCAM-1) and intercellular adhesion molecule-1 (sICAM-1) in patients with type 2 diabetes. Eighty-two Japanese type 2 diabetic patients underwent a complete history and physical examination, determination of blood chemistries, sRAGE, AGEs, sVCAM-1 and sICAM-1. Multiple regression analysis revealed that serum levels of AGEs and sVCAM-1 were independently correlated with sRAGE. This study demonstrated that serum levels of sRAGE were positively associated with circulating AGEs and sVCAM-1 levels in type 2 diabetic patients. Our present observations suggest sRAGE level may be elevated in response to circulating AGEs, thus being a novel marker of vascular injury in patients with type 2 diabetes.</description><identifier>ISSN: 0026-2862</identifier><identifier>EISSN: 1095-9319</identifier><identifier>DOI: 10.1016/j.mvr.2007.09.004</identifier><identifier>PMID: 18474381</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; AGEs ; Atherosclerosis ; Biomarkers - blood ; Body Mass Index ; Coronary Artery Disease - blood ; Coronary Artery Disease - complications ; Diabetes ; Diabetes Complications - blood ; Diabetes Complications - diagnosis ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetic Nephropathies - blood ; Diabetic Nephropathies - diagnosis ; Female ; Glycation End Products, Advanced - blood ; Humans ; Intercellular Adhesion Molecule-1 - blood ; Linear Models ; Male ; Middle Aged ; Multivariate Analysis ; Receptor for Advanced Glycation End Products ; Receptors, Immunologic - blood ; Solubility ; sRAGE ; sVCAM-1 ; Vascular Cell Adhesion Molecule-1 - blood ; Vascular Diseases - blood ; Vascular Diseases - diagnosis</subject><ispartof>Microvascular research, 2008-05, Vol.76 (1), p.52-56</ispartof><rights>2007 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-5ad7b8828056542602e2a80eb1b35c9be0a29395918f9e87e7e4e3c9c80699763</citedby><cites>FETCH-LOGICAL-c351t-5ad7b8828056542602e2a80eb1b35c9be0a29395918f9e87e7e4e3c9c80699763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0026286207001173$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18474381$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakamura, Kazuo</creatorcontrib><creatorcontrib>Yamagishi, Sho-ichi</creatorcontrib><creatorcontrib>Adachi, Hisashi</creatorcontrib><creatorcontrib>Matsui, Takanori</creatorcontrib><creatorcontrib>Kurita-Nakamura, Yayoi</creatorcontrib><creatorcontrib>Takeuchi, Masayoshi</creatorcontrib><creatorcontrib>Inoue, Hiroyoshi</creatorcontrib><creatorcontrib>Imaizumi, Tsutomu</creatorcontrib><title>Serum levels of soluble form of receptor for advanced glycation end products (sRAGE) are positively associated with circulating AGEs and soluble form of VCAM-1 in patients with type 2 diabetes</title><title>Microvascular research</title><addtitle>Microvasc Res</addtitle><description>We have recently found that soluble form of receptor for advanced glycation end products (sRAGE) levels are positively associated with inflammatory biomarkers and the presence of coronary artery disease (CAD) in type 2 diabetic patients. Since advanced glycation end products (AGEs) up-regulate RAGE expression and endogenous sRAGE could be generated from the cleavage of cell surface RAGE, it is conceivable that sRAGE is positively associated with circulating AGEs levels in diabetes. In this study, we examined whether sRAGE were correlated to circulating levels of AGEs and soluble forms of vascular cell adhesion molecule-1 (sVCAM-1) and intercellular adhesion molecule-1 (sICAM-1) in patients with type 2 diabetes. Eighty-two Japanese type 2 diabetic patients underwent a complete history and physical examination, determination of blood chemistries, sRAGE, AGEs, sVCAM-1 and sICAM-1. Multiple regression analysis revealed that serum levels of AGEs and sVCAM-1 were independently correlated with sRAGE. This study demonstrated that serum levels of sRAGE were positively associated with circulating AGEs and sVCAM-1 levels in type 2 diabetic patients. Our present observations suggest sRAGE level may be elevated in response to circulating AGEs, thus being a novel marker of vascular injury in patients with type 2 diabetes.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>AGEs</subject><subject>Atherosclerosis</subject><subject>Biomarkers - blood</subject><subject>Body Mass Index</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - complications</subject><subject>Diabetes</subject><subject>Diabetes Complications - blood</subject><subject>Diabetes Complications - diagnosis</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetic Nephropathies - blood</subject><subject>Diabetic Nephropathies - diagnosis</subject><subject>Female</subject><subject>Glycation End Products, Advanced - blood</subject><subject>Humans</subject><subject>Intercellular Adhesion Molecule-1 - blood</subject><subject>Linear Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Receptor for Advanced Glycation End Products</subject><subject>Receptors, Immunologic - blood</subject><subject>Solubility</subject><subject>sRAGE</subject><subject>sVCAM-1</subject><subject>Vascular Cell Adhesion Molecule-1 - blood</subject><subject>Vascular Diseases - blood</subject><subject>Vascular Diseases - diagnosis</subject><issn>0026-2862</issn><issn>1095-9319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctq3DAUhkVpaKZpH6CbolVJF3aP5JtEV8OQJoGEQm9bIcvHqQbbciV5yrxdH62azkAgi67EEd__H6SPkDcMcgas_rDNx53POUCTg8wBymdkxUBWmSyYfE5WALzOuKj5OXkZwhaAsUryF-ScibIpC8FW5M9X9MtIB9zhEKjraXDD0g5Ie-fHw-zR4BydP1xQ3e30ZLCjD8Pe6GjdRHHq6Oxdt5gY6GX4sr6-ek-1Rzq7YKNNtXuqQ3DG6piCv238SY31ZhlSfnqgiQ9Up5Kni39s1vcZo3aicyJxSvX_wnE_I-W0s7rFiOEVOev1EPD16bwg3z9dfdvcZHefr28367vMFBWLWaW7phWCC6jqquQ1cORaALasLSojWwTNZSEryUQvUTTYYImFkUZALWVTFxfk3bE3PfbXgiGq0QaDw6AndEtQteRlUQJLIDuCxrsQPPZq9nbUfq8YqIM2tVVJmzpoUyBV0pYyb0_lSzti95g4eUrAxyOQLOHOolfBpD9JKmwSFFXn7H_q_wIwHapc</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>Nakamura, Kazuo</creator><creator>Yamagishi, Sho-ichi</creator><creator>Adachi, Hisashi</creator><creator>Matsui, Takanori</creator><creator>Kurita-Nakamura, Yayoi</creator><creator>Takeuchi, Masayoshi</creator><creator>Inoue, Hiroyoshi</creator><creator>Imaizumi, Tsutomu</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080501</creationdate><title>Serum levels of soluble form of receptor for advanced glycation end products (sRAGE) are positively associated with circulating AGEs and soluble form of VCAM-1 in patients with type 2 diabetes</title><author>Nakamura, Kazuo ; Yamagishi, Sho-ichi ; Adachi, Hisashi ; Matsui, Takanori ; Kurita-Nakamura, Yayoi ; Takeuchi, Masayoshi ; Inoue, Hiroyoshi ; Imaizumi, Tsutomu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-5ad7b8828056542602e2a80eb1b35c9be0a29395918f9e87e7e4e3c9c80699763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>AGEs</topic><topic>Atherosclerosis</topic><topic>Biomarkers - blood</topic><topic>Body Mass Index</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - complications</topic><topic>Diabetes</topic><topic>Diabetes Complications - blood</topic><topic>Diabetes Complications - diagnosis</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetic Nephropathies - blood</topic><topic>Diabetic Nephropathies - diagnosis</topic><topic>Female</topic><topic>Glycation End Products, Advanced - blood</topic><topic>Humans</topic><topic>Intercellular Adhesion Molecule-1 - blood</topic><topic>Linear Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Receptor for Advanced Glycation End Products</topic><topic>Receptors, Immunologic - blood</topic><topic>Solubility</topic><topic>sRAGE</topic><topic>sVCAM-1</topic><topic>Vascular Cell Adhesion Molecule-1 - blood</topic><topic>Vascular Diseases - blood</topic><topic>Vascular Diseases - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakamura, Kazuo</creatorcontrib><creatorcontrib>Yamagishi, Sho-ichi</creatorcontrib><creatorcontrib>Adachi, Hisashi</creatorcontrib><creatorcontrib>Matsui, Takanori</creatorcontrib><creatorcontrib>Kurita-Nakamura, Yayoi</creatorcontrib><creatorcontrib>Takeuchi, Masayoshi</creatorcontrib><creatorcontrib>Inoue, Hiroyoshi</creatorcontrib><creatorcontrib>Imaizumi, Tsutomu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Microvascular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakamura, Kazuo</au><au>Yamagishi, Sho-ichi</au><au>Adachi, Hisashi</au><au>Matsui, Takanori</au><au>Kurita-Nakamura, Yayoi</au><au>Takeuchi, Masayoshi</au><au>Inoue, Hiroyoshi</au><au>Imaizumi, Tsutomu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum levels of soluble form of receptor for advanced glycation end products (sRAGE) are positively associated with circulating AGEs and soluble form of VCAM-1 in patients with type 2 diabetes</atitle><jtitle>Microvascular research</jtitle><addtitle>Microvasc Res</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>76</volume><issue>1</issue><spage>52</spage><epage>56</epage><pages>52-56</pages><issn>0026-2862</issn><eissn>1095-9319</eissn><abstract>We have recently found that soluble form of receptor for advanced glycation end products (sRAGE) levels are positively associated with inflammatory biomarkers and the presence of coronary artery disease (CAD) in type 2 diabetic patients. Since advanced glycation end products (AGEs) up-regulate RAGE expression and endogenous sRAGE could be generated from the cleavage of cell surface RAGE, it is conceivable that sRAGE is positively associated with circulating AGEs levels in diabetes. In this study, we examined whether sRAGE were correlated to circulating levels of AGEs and soluble forms of vascular cell adhesion molecule-1 (sVCAM-1) and intercellular adhesion molecule-1 (sICAM-1) in patients with type 2 diabetes. Eighty-two Japanese type 2 diabetic patients underwent a complete history and physical examination, determination of blood chemistries, sRAGE, AGEs, sVCAM-1 and sICAM-1. Multiple regression analysis revealed that serum levels of AGEs and sVCAM-1 were independently correlated with sRAGE. This study demonstrated that serum levels of sRAGE were positively associated with circulating AGEs and sVCAM-1 levels in type 2 diabetic patients. Our present observations suggest sRAGE level may be elevated in response to circulating AGEs, thus being a novel marker of vascular injury in patients with type 2 diabetes.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18474381</pmid><doi>10.1016/j.mvr.2007.09.004</doi><tpages>5</tpages></addata></record> |
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| ispartof | Microvascular research, 2008-05, Vol.76 (1), p.52-56 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aged Aged, 80 and over AGEs Atherosclerosis Biomarkers - blood Body Mass Index Coronary Artery Disease - blood Coronary Artery Disease - complications Diabetes Diabetes Complications - blood Diabetes Complications - diagnosis Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetic Nephropathies - blood Diabetic Nephropathies - diagnosis Female Glycation End Products, Advanced - blood Humans Intercellular Adhesion Molecule-1 - blood Linear Models Male Middle Aged Multivariate Analysis Receptor for Advanced Glycation End Products Receptors, Immunologic - blood Solubility sRAGE sVCAM-1 Vascular Cell Adhesion Molecule-1 - blood Vascular Diseases - blood Vascular Diseases - diagnosis |
| title | Serum levels of soluble form of receptor for advanced glycation end products (sRAGE) are positively associated with circulating AGEs and soluble form of VCAM-1 in patients with type 2 diabetes |
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