Hormonal integration of neurochemical and sensory signals governing female reproductive behavior

This review focuses on findings from our laboratory regarding mechanisms by which the ovarian steroid hormones, estradiol (E 2) and progesterone (P), act in the hypothalamus (HYP) to regulate the expression of lordosis, an important component of female reproductive behavior in rats and many other sp...

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Veröffentlicht in:Behavioural Brain Research 1999-11, Vol.105 (1), p.93-103
Hauptverfasser: Etgen, Anne M, Chu, Hsiao-Pai, Fiber, Jeannie M, Karkanias, George B, Morales, Jose M
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container_end_page 103
container_issue 1
container_start_page 93
container_title Behavioural Brain Research
container_volume 105
creator Etgen, Anne M
Chu, Hsiao-Pai
Fiber, Jeannie M
Karkanias, George B
Morales, Jose M
description This review focuses on findings from our laboratory regarding mechanisms by which the ovarian steroid hormones, estradiol (E 2) and progesterone (P), act in the hypothalamus (HYP) to regulate the expression of lordosis, an important component of female reproductive behavior in rats and many other species. The first section summarizes recent work suggesting that cGMP, perhaps via P-receptor activation, may be an intracellular mediator of the facilitatory actions of a variety of hormones and neurotransmitters on lordosis behavior in E 2-primed rats. In the second section, we focus on E 2 and P regulation of norepinephrine (NE) neurotransmission in the HYP. We review evidence that ovarian hormones act both peripherally and centrally to determine whether NE is released in the HYP in response to copulatory stimuli. We also suggest that the steroid milieu determines the cellular responses of hypothalamic neurons to released NE, favoring the activation of pathways implicated in the facilitation of both lordosis behavior and the preovulatory gonadotropin surge. It is likely that E 2 and P have similar actions on other neurotransmitter and neuromodulator systems, thereby maximizing the probability that females are sexually receptive during the periovulatory period.
doi_str_mv 10.1016/S0166-4328(99)00085-6
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subjects Animals
Brain Mapping
cGMP
Estradiol
Estradiol - physiology
Female
Humans
Hypothalamus
Hypothalamus - physiology
Lordosis
Neurotransmitter Agents - physiology
Nitric oxide
Norepinephrine
Preoptic area
Progesterone
Progesterone - physiology
Rats
Sexual Behavior - physiology
Sexual Behavior, Animal - physiology
title Hormonal integration of neurochemical and sensory signals governing female reproductive behavior
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