Expression of the inhibitor of apoptosis protein family in multiple sclerosis reveals a potential immunomodulatory role during autoimmune mediated demyelination

A failure of autoreactive T cells to undergo apoptosis may contribute to the pathogenesis of multiple sclerosis (MS). The role of the inhibitor of apoptosis (IAP) family of anti-apoptotic proteins such as X-linked IAP (XIAP), human inhibitor of apoptosis-1 (HIAP-1), human inhibitor of apoptosis-2 (H...

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Veröffentlicht in:	Multiple sclerosis 2008-06, Vol.14 (5), p.577-594
Hauptverfasser:	Hebb, ALO, Moore, CS, Bhan, V, Campbell, T, Fisk, JD, Robertson, HA, Thorne, M, Lacasse, E, Holcik, M, Gillard, J, Crocker, SJ, Robertson, GS
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Autoimmunity - genetics Autoimmunity - immunology Baculoviral IAP Repeat-Containing 3 Protein Biological and medical sciences Blotting, Western Brain - pathology Brain - physiology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Demyelinating Diseases - genetics Demyelinating Diseases - immunology Demyelinating Diseases - pathology Female Gene Expression - immunology Gene Expression Profiling Humans Immunologic Factors - genetics Immunologic Factors - immunology Inhibitor of Apoptosis Proteins - genetics Inhibitor of Apoptosis Proteins - immunology Inhibitor of Apoptosis Proteins - metabolism Male Medical sciences Microglia - immunology Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - immunology Microtubule-Associated Proteins - metabolism Middle Aged Multiple Sclerosis - genetics Multiple Sclerosis - immunology Multiple Sclerosis - pathology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neoplasm Proteins - genetics Neoplasm Proteins - immunology Neoplasm Proteins - metabolism Neurology Neuronal Apoptosis-Inhibitory Protein - genetics Neuronal Apoptosis-Inhibitory Protein - immunology Neuronal Apoptosis-Inhibitory Protein - metabolism T-Lymphocytes - immunology T-Lymphocytes - metabolism Ubiquitin-Protein Ligases X-Linked Inhibitor of Apoptosis Protein - genetics X-Linked Inhibitor of Apoptosis Protein - immunology X-Linked Inhibitor of Apoptosis Protein - metabolism
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