Secreted Frizzled-Related Protein 4 Regulates Two Wnt7a Signaling Pathways and Inhibits Proliferation in Endometrial Cancer Cells

In the endometrium, hormonal effects on epithelial cells are often elicited through stromal hormone receptors via unknown paracrine mechanisms. Several lines of evidence support the hypothesis that Wnts participate in stromal-epithelial cell communication. Wnt7a is expressed in the luminal epitheliu...

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Veröffentlicht in:	Molecular cancer research 2008-06, Vol.6 (6), p.1017-1028
Hauptverfasser:	Carmon, Kendra S, Loose, David S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - antagonists & inhibitors beta Catenin - metabolism Cell Line, Tumor Cell Proliferation Endometrial Neoplasms - metabolism Endometrial Neoplasms - pathology Endometrium Female Frizzled Receptors - analysis Frizzled Receptors - metabolism Humans JNK Mitogen-Activated Protein Kinases - metabolism Paracrine Communication Proliferation Proto-Oncogene Proteins - analysis Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - metabolism Rats Rats, Sprague-Dawley Receptors, G-Protein-Coupled - analysis Receptors, G-Protein-Coupled - metabolism SFRP4 Signal Transduction Wnt Proteins - analysis Wnt Proteins - antagonists & inhibitors Wnt Proteins - metabolism Wnt Signaling Wnt7a
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