A SNP in the ACT gene associated with astrocytosis and rapid cognitive decline in AD

Abstract There is biochemical and animal model evidence supporting a pathological role of the ACT gene in AD. However, direct genetic evidence remains controversial and has been mostly limited to individual single nucleotide polymorphism (SNP) analysis. To resolve this apparent conflict we have used...

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Veröffentlicht in:	Neurobiology of aging 2008-08, Vol.29 (8), p.1167-1176
Hauptverfasser:	Belbin, O, Dunn, J.L, Chappell, S, Ritchie, A.E, Ling, Y, Morgan, L, Pritchard, A, Warden, D.R, Lendon, C.L, Lehmann, D.J, Mann, D.M.A, Smith, A.D, Kalsheker, N, Morgan, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alpha-1-antichymotrypsin Alzheimer Disease - epidemiology Alzheimer Disease - genetics Alzheimer's disease Case-Control Studies Cognition Disorders - epidemiology Cognition Disorders - genetics Comorbidity Female Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Gliosis - epidemiology Gliosis - genetics Haplotypes Humans Incidence Internal Medicine LIM Domain Proteins Male Neurology Polymorphism, Single Nucleotide - genetics Single nucleotide polymorphisms Transcription Factors - genetics United Kingdom - epidemiology
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