Properties and Applications of Antimicrobial Peptides in Biodefense Against Biological Warfare Threat Agents
Recent advances in knowledge of the properties of antimicrobial peptides (AMPs) are reviewed. AMPs are typically small, positively charged, amphipathic peptides that interact electrostatically and non-stereospecifically with the bacterial cell membrane, resulting in its permeabilization and cell dea...
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| Veröffentlicht in: | Critical reviews in microbiology 2008, Vol.34 (2), p.89-107 |
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| container_title | Critical reviews in microbiology |
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| creator | Dawson, Raymond Murray Liu, Chun-Qiang |
| description | Recent advances in knowledge of the properties of antimicrobial peptides (AMPs) are reviewed. AMPs are typically small, positively charged, amphipathic peptides that interact electrostatically and non-stereospecifically with the bacterial cell membrane, resulting in its permeabilization and cell death. Classes of AMPs, their mechanisms of action, hemolytic activity, and cytotoxicity towards host cells are discussed. A particular focus is AMPs with potential for use in defense against biological warfare agents. Some AMPs cytotoxic to Bacillus anthracis have been described. Synthesis of these peptides in multivalent form leads to a synergistic increase in antibacterial activity. Strategies to enhance the potency, stability, and selectivity of AMPs are discussed. |
| doi_str_mv | 10.1080/10408410802143808 |
| format | Article |
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Strategies to enhance the potency, stability, and selectivity of AMPs are discussed.</description><subject>Anthrax</subject><subject>Anti-Infective Agents - chemistry</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Anti-Infective Agents - therapeutic use</subject><subject>Antimicrobial Peptide</subject><subject>Bacillus anthracis</subject><subject>Base Sequence</subject><subject>Biological Warfare</subject><subject>Biological Warfare Agents</subject><subject>Communicable Diseases - drug therapy</subject><subject>Communicable Diseases - microbiology</subject><subject>Drug Resistance, Microbial</subject><subject>Drug Stability</subject><subject>Humans</subject><subject>Molecular Conformation</subject><subject>Multivalency</subject><subject>Peptides - chemistry</subject><subject>Peptides - pharmacology</subject><subject>Peptides - therapeutic use</subject><issn>1040-841X</issn><issn>1549-7828</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtr3TAQhUVpaB7tD-imaNWdU8mWbJl2cxv6CASSRUq7M3qMchVkyZV0Kfn3kbkXSikkqxlmvnMY5iD0lpJzSgT5QAkjgq1tS1kniHiBTihnYzOIVrysfd03Ffh1jE5zvieE9C3jr9AxFbwXou9OkL9JcYFUHGQsg8GbZfFOy-JiyDhavAnFzU6nqJz0-AaW4kxFXcCfXTRgIWTAmzvpQi7ryMe7Kvf4p0xWJsC32wSyVAJCya_RkZU-w5tDPUM_vn65vfjeXF1_u7zYXDWa9X1pOFUGBitAETMKRS0V2gBhmhPTmcEyLriCTg2yV9wyOg5SK7a-ghnbMdadofd73yXF3zvIZZpd1uC9DBB3eerHths5Fc-CXXUjnAzPgi0Z-Mjb1ZHuwfqynBPYaUlululhomRak5r-C61q3h3Md2oG81dxSKkCn_aACzamWf6JyZupyAcfk00yaFdPfcr_4z_yLUhftrrGM93HXQo1iieuewRf2rgH</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Dawson, Raymond Murray</creator><creator>Liu, Chun-Qiang</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7U5</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Properties and Applications of Antimicrobial Peptides in Biodefense Against Biological Warfare Threat Agents</title><author>Dawson, Raymond Murray ; 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| ispartof | Critical reviews in microbiology, 2008, Vol.34 (2), p.89-107 |
| issn | 1040-841X 1549-7828 |
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| source | MEDLINE; Taylor & Francis Journals Complete |
| subjects | Anthrax Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Anti-Infective Agents - therapeutic use Antimicrobial Peptide Bacillus anthracis Base Sequence Biological Warfare Biological Warfare Agents Communicable Diseases - drug therapy Communicable Diseases - microbiology Drug Resistance, Microbial Drug Stability Humans Molecular Conformation Multivalency Peptides - chemistry Peptides - pharmacology Peptides - therapeutic use |
| title | Properties and Applications of Antimicrobial Peptides in Biodefense Against Biological Warfare Threat Agents |
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