Quality‐of‐life outcomes for men treated with cryosurgery for localized prostate carcinoma
BACKGROUND Cryosurgery was introduced as an alternative to radiotherapy or radical prostatectomy in the mid‐1960s. Although it met the primary objective of achieving local control, it was largely abandoned due to a high incidence of complications. Technologic advances in the areas of imaging and ure...
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| Veröffentlicht in: | Cancer 1999-11, Vol.86 (9), p.1793-1801 |
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| creator | Robinson, John W. Saliken, John C. Donnelly, Bryan J. Barnes, Penny Guyn, Lindsay |
| description | BACKGROUND
Cryosurgery was introduced as an alternative to radiotherapy or radical prostatectomy in the mid‐1960s. Although it met the primary objective of achieving local control, it was largely abandoned due to a high incidence of complications. Technologic advances in the areas of imaging and urethral warming have renewed interest in this treatment methodology. The aim of the current study was to determine the quality of life of men enrolled in a Phase II clinical trial of cryosurgery for the treatment of localized prostate carcinoma.
METHODS
Men were administered the Functional Assessment of Cancer Treatment–Prostate (FACT‐P) prior to their treatment and at 6 weeks and 3, 6, and 12 months posttreatment.
RESULTS
By 12 months after cryosurgery, most of the FACT‐P subscales had returned to pretreatment levels, following a decline in well‐being immediately after cryosurgery. There were two exceptions to this general trend: At 12 months, impairments in social/family well‐being and sexual function still remained. The average time to return to work after therapy was 3 weeks. Stay in hospital after treatment was limited to 1 day for 94% of the participants. Compared with men who received the standard treatments of radical prostatectomy and radical radiotherapy, men treated with cryosurgery appeared to have a similar quality of life, with perhaps the exception of decreased sexual function.
CONCLUSIONS
The quality‐of‐life outcomes of this study support the current renewed interest in cryosurgery. The severe impairments reported in other studies were not seen in this sample. In fact, it appeared that all aspects of the participants' well‐being had returned to pretreatment levels by 12 months, with the exception of sexual function. Cancer 1999;86:1793–1801. © 1999 American Cancer Society.
Men treated with cryosurgery for localized prostate carcinoma achieved a complete recovery within most aspects of quality of life by 1 year after treatment. These results support the current renewed interest in cryosurgery. |
| doi_str_mv | 10.1002/(SICI)1097-0142(19991101)86:9<1793::AID-CNCR22>3.0.CO;2-J |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69238097</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69238097</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4832-d2d95230909df3a868921d1bc2e9323309d9391dd401a528fd508c4c397e7e4a3</originalsourceid><addsrcrecordid>eNqFkNmKFDEUhoMoTjv6ClIXIjMX1WapJacVoSm3HgYbN1AED5kkpSVVnTGpYiivfASf0ScxZbULKHiTkHO-_Px8hKwZXTJK-Z2jF5tqc8wolCllGT9iAMAYZceyWME9VoJYrdabB2n1tHrO-X2xpMtqe5enJ5fI4tevy2RBKZVpnonXB-RaCB_js-S5uEoOGM2zMs_Fgrx7Nqi26cdvX766Oh5tU9vEDb12nQ1J7XzS2V3Se6t6a5KLpv-QaD-6MPj31o8_gNbpGPE5rs-9C30EE628bnauU9fJlVq1wd7Y34fk1aOHL6sn6en28aZan6Y6k4KnhhvIuaBAwdRCyUICZ4adaW5BcBEXBgQwYzLKVM5lbXIqdaYFlLa0mRKH5PacGyt8GmzosWuCtm2rdtYNAQvgQkYzEXwzgzp2Dd7WeO6bTvkRGcVJPuIkHyeNOGnEn_JRFgg4yUeM8nGWjwIpVlvkeBKzb-5LDGedNX8kz7YjcGsPqBCd1V7tdBN-cyALUWQReztjF01rx78K_r_fP-vtJ-I7xtKwLQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69238097</pqid></control><display><type>article</type><title>Quality‐of‐life outcomes for men treated with cryosurgery for localized prostate carcinoma</title><source>MEDLINE</source><source>Wiley Free Content</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library All Journals</source><source>Alma/SFX Local Collection</source><creator>Robinson, John W. ; Saliken, John C. ; Donnelly, Bryan J. ; Barnes, Penny ; Guyn, Lindsay</creator><creatorcontrib>Robinson, John W. ; Saliken, John C. ; Donnelly, Bryan J. ; Barnes, Penny ; Guyn, Lindsay</creatorcontrib><description>BACKGROUND
Cryosurgery was introduced as an alternative to radiotherapy or radical prostatectomy in the mid‐1960s. Although it met the primary objective of achieving local control, it was largely abandoned due to a high incidence of complications. Technologic advances in the areas of imaging and urethral warming have renewed interest in this treatment methodology. The aim of the current study was to determine the quality of life of men enrolled in a Phase II clinical trial of cryosurgery for the treatment of localized prostate carcinoma.
METHODS
Men were administered the Functional Assessment of Cancer Treatment–Prostate (FACT‐P) prior to their treatment and at 6 weeks and 3, 6, and 12 months posttreatment.
RESULTS
By 12 months after cryosurgery, most of the FACT‐P subscales had returned to pretreatment levels, following a decline in well‐being immediately after cryosurgery. There were two exceptions to this general trend: At 12 months, impairments in social/family well‐being and sexual function still remained. The average time to return to work after therapy was 3 weeks. Stay in hospital after treatment was limited to 1 day for 94% of the participants. Compared with men who received the standard treatments of radical prostatectomy and radical radiotherapy, men treated with cryosurgery appeared to have a similar quality of life, with perhaps the exception of decreased sexual function.
CONCLUSIONS
The quality‐of‐life outcomes of this study support the current renewed interest in cryosurgery. The severe impairments reported in other studies were not seen in this sample. In fact, it appeared that all aspects of the participants' well‐being had returned to pretreatment levels by 12 months, with the exception of sexual function. Cancer 1999;86:1793–1801. © 1999 American Cancer Society.
Men treated with cryosurgery for localized prostate carcinoma achieved a complete recovery within most aspects of quality of life by 1 year after treatment. These results support the current renewed interest in cryosurgery.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/(SICI)1097-0142(19991101)86:9<1793::AID-CNCR22>3.0.CO;2-J</identifier><identifier>PMID: 10547553</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Aged ; Appetite ; Biological and medical sciences ; cryosurgery ; Cryosurgery - adverse effects ; Defecation ; Humans ; Male ; Medical sciences ; Middle Aged ; Pain - psychology ; Physician-Patient Relations ; Prospective Studies ; Prostate ; prostate carcinoma ; Prostatic Neoplasms - psychology ; Prostatic Neoplasms - surgery ; Quality of Life ; radical prostatectomy ; radiotherapy ; Sexual Behavior - psychology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the genital tract and mammary gland ; Time Factors ; Urination</subject><ispartof>Cancer, 1999-11, Vol.86 (9), p.1793-1801</ispartof><rights>Copyright © 1999 American Cancer Society</rights><rights>1999 INIST-CNRS</rights><rights>Copyright 1999 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4832-d2d95230909df3a868921d1bc2e9323309d9391dd401a528fd508c4c397e7e4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-0142%2819991101%2986%3A9%3C1793%3A%3AAID-CNCR22%3E3.0.CO%3B2-J$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-0142%2819991101%2986%3A9%3C1793%3A%3AAID-CNCR22%3E3.0.CO%3B2-J$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,1432,27922,27923,45572,45573,46407,46831</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1986364$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10547553$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Robinson, John W.</creatorcontrib><creatorcontrib>Saliken, John C.</creatorcontrib><creatorcontrib>Donnelly, Bryan J.</creatorcontrib><creatorcontrib>Barnes, Penny</creatorcontrib><creatorcontrib>Guyn, Lindsay</creatorcontrib><title>Quality‐of‐life outcomes for men treated with cryosurgery for localized prostate carcinoma</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
Cryosurgery was introduced as an alternative to radiotherapy or radical prostatectomy in the mid‐1960s. Although it met the primary objective of achieving local control, it was largely abandoned due to a high incidence of complications. Technologic advances in the areas of imaging and urethral warming have renewed interest in this treatment methodology. The aim of the current study was to determine the quality of life of men enrolled in a Phase II clinical trial of cryosurgery for the treatment of localized prostate carcinoma.
METHODS
Men were administered the Functional Assessment of Cancer Treatment–Prostate (FACT‐P) prior to their treatment and at 6 weeks and 3, 6, and 12 months posttreatment.
RESULTS
By 12 months after cryosurgery, most of the FACT‐P subscales had returned to pretreatment levels, following a decline in well‐being immediately after cryosurgery. There were two exceptions to this general trend: At 12 months, impairments in social/family well‐being and sexual function still remained. The average time to return to work after therapy was 3 weeks. Stay in hospital after treatment was limited to 1 day for 94% of the participants. Compared with men who received the standard treatments of radical prostatectomy and radical radiotherapy, men treated with cryosurgery appeared to have a similar quality of life, with perhaps the exception of decreased sexual function.
CONCLUSIONS
The quality‐of‐life outcomes of this study support the current renewed interest in cryosurgery. The severe impairments reported in other studies were not seen in this sample. In fact, it appeared that all aspects of the participants' well‐being had returned to pretreatment levels by 12 months, with the exception of sexual function. Cancer 1999;86:1793–1801. © 1999 American Cancer Society.
Men treated with cryosurgery for localized prostate carcinoma achieved a complete recovery within most aspects of quality of life by 1 year after treatment. These results support the current renewed interest in cryosurgery.</description><subject>Aged</subject><subject>Appetite</subject><subject>Biological and medical sciences</subject><subject>cryosurgery</subject><subject>Cryosurgery - adverse effects</subject><subject>Defecation</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pain - psychology</subject><subject>Physician-Patient Relations</subject><subject>Prospective Studies</subject><subject>Prostate</subject><subject>prostate carcinoma</subject><subject>Prostatic Neoplasms - psychology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Quality of Life</subject><subject>radical prostatectomy</subject><subject>radiotherapy</subject><subject>Sexual Behavior - psychology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the genital tract and mammary gland</subject><subject>Time Factors</subject><subject>Urination</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkNmKFDEUhoMoTjv6ClIXIjMX1WapJacVoSm3HgYbN1AED5kkpSVVnTGpYiivfASf0ScxZbULKHiTkHO-_Px8hKwZXTJK-Z2jF5tqc8wolCllGT9iAMAYZceyWME9VoJYrdabB2n1tHrO-X2xpMtqe5enJ5fI4tevy2RBKZVpnonXB-RaCB_js-S5uEoOGM2zMs_Fgrx7Nqi26cdvX766Oh5tU9vEDb12nQ1J7XzS2V3Se6t6a5KLpv-QaD-6MPj31o8_gNbpGPE5rs-9C30EE628bnauU9fJlVq1wd7Y34fk1aOHL6sn6en28aZan6Y6k4KnhhvIuaBAwdRCyUICZ4adaW5BcBEXBgQwYzLKVM5lbXIqdaYFlLa0mRKH5PacGyt8GmzosWuCtm2rdtYNAQvgQkYzEXwzgzp2Dd7WeO6bTvkRGcVJPuIkHyeNOGnEn_JRFgg4yUeM8nGWjwIpVlvkeBKzb-5LDGedNX8kz7YjcGsPqBCd1V7tdBN-cyALUWQReztjF01rx78K_r_fP-vtJ-I7xtKwLQ</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>Robinson, John W.</creator><creator>Saliken, John C.</creator><creator>Donnelly, Bryan J.</creator><creator>Barnes, Penny</creator><creator>Guyn, Lindsay</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991101</creationdate><title>Quality‐of‐life outcomes for men treated with cryosurgery for localized prostate carcinoma</title><author>Robinson, John W. ; Saliken, John C. ; Donnelly, Bryan J. ; Barnes, Penny ; Guyn, Lindsay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4832-d2d95230909df3a868921d1bc2e9323309d9391dd401a528fd508c4c397e7e4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Aged</topic><topic>Appetite</topic><topic>Biological and medical sciences</topic><topic>cryosurgery</topic><topic>Cryosurgery - adverse effects</topic><topic>Defecation</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pain - psychology</topic><topic>Physician-Patient Relations</topic><topic>Prospective Studies</topic><topic>Prostate</topic><topic>prostate carcinoma</topic><topic>Prostatic Neoplasms - psychology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Quality of Life</topic><topic>radical prostatectomy</topic><topic>radiotherapy</topic><topic>Sexual Behavior - psychology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the genital tract and mammary gland</topic><topic>Time Factors</topic><topic>Urination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Robinson, John W.</creatorcontrib><creatorcontrib>Saliken, John C.</creatorcontrib><creatorcontrib>Donnelly, Bryan J.</creatorcontrib><creatorcontrib>Barnes, Penny</creatorcontrib><creatorcontrib>Guyn, Lindsay</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Robinson, John W.</au><au>Saliken, John C.</au><au>Donnelly, Bryan J.</au><au>Barnes, Penny</au><au>Guyn, Lindsay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quality‐of‐life outcomes for men treated with cryosurgery for localized prostate carcinoma</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>86</volume><issue>9</issue><spage>1793</spage><epage>1801</epage><pages>1793-1801</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND
Cryosurgery was introduced as an alternative to radiotherapy or radical prostatectomy in the mid‐1960s. Although it met the primary objective of achieving local control, it was largely abandoned due to a high incidence of complications. Technologic advances in the areas of imaging and urethral warming have renewed interest in this treatment methodology. The aim of the current study was to determine the quality of life of men enrolled in a Phase II clinical trial of cryosurgery for the treatment of localized prostate carcinoma.
METHODS
Men were administered the Functional Assessment of Cancer Treatment–Prostate (FACT‐P) prior to their treatment and at 6 weeks and 3, 6, and 12 months posttreatment.
RESULTS
By 12 months after cryosurgery, most of the FACT‐P subscales had returned to pretreatment levels, following a decline in well‐being immediately after cryosurgery. There were two exceptions to this general trend: At 12 months, impairments in social/family well‐being and sexual function still remained. The average time to return to work after therapy was 3 weeks. Stay in hospital after treatment was limited to 1 day for 94% of the participants. Compared with men who received the standard treatments of radical prostatectomy and radical radiotherapy, men treated with cryosurgery appeared to have a similar quality of life, with perhaps the exception of decreased sexual function.
CONCLUSIONS
The quality‐of‐life outcomes of this study support the current renewed interest in cryosurgery. The severe impairments reported in other studies were not seen in this sample. In fact, it appeared that all aspects of the participants' well‐being had returned to pretreatment levels by 12 months, with the exception of sexual function. Cancer 1999;86:1793–1801. © 1999 American Cancer Society.
Men treated with cryosurgery for localized prostate carcinoma achieved a complete recovery within most aspects of quality of life by 1 year after treatment. These results support the current renewed interest in cryosurgery.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>10547553</pmid><doi>10.1002/(SICI)1097-0142(19991101)86:9<1793::AID-CNCR22>3.0.CO;2-J</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Appetite Biological and medical sciences cryosurgery Cryosurgery - adverse effects Defecation Humans Male Medical sciences Middle Aged Pain - psychology Physician-Patient Relations Prospective Studies Prostate prostate carcinoma Prostatic Neoplasms - psychology Prostatic Neoplasms - surgery Quality of Life radical prostatectomy radiotherapy Sexual Behavior - psychology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the genital tract and mammary gland Time Factors Urination |
| title | Quality‐of‐life outcomes for men treated with cryosurgery for localized prostate carcinoma |
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