PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

Agonist-induced activation of peroxisome proliferator-activated receptor γ (PPARγ) is known to cause adipocyte differentiation and insulin sensitivity. The biological role of PPARγ was investigated by gene targeting. Homozygous PPARγ-deficient embryos died at 10.5–11.5 dpc due to placental dysfuncti...

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Veröffentlicht in:	Molecular cell 1999-10, Vol.4 (4), p.597-609
Hauptverfasser:	Kubota, Naoto, Terauchi, Yasuo, Miki, Hiroshi, Tamemoto, Hiroyuki, Yamauchi, Toshimasa, Komeda, Kajuro, Satoh, Shinobu, Nakano, Ryosuke, Ishii, Chikara, Sugiyama, Takuya, Eto, Kazuhiro, Tsubamoto, Yoshiharu, Okuno, Akira, Murakami, Koji, Sekihara, Hisahiko, Hasegawa, Go, Naito, Makoto, Toyoshima, Yasushi, Tanaka, Satoshi, Shiota, Kunio, Kitamura, Toshio, Fujita, Toshiro, Ezaki, Osamu, Aizawa, Shinichi, Nagai, Ryozo, Tobe, Kazuyuki, Kimura, Satoshi, Kadowaki, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - metabolism Animals Blood Glucose - metabolism Body Weight - genetics Cell Differentiation - genetics Cell Size - genetics Diet Eating Energy Metabolism Fats - pharmacology Fetal Viability - genetics Hypoglycemic Agents - pharmacology Insulin Resistance - genetics Leptin - metabolism Mice Mice, Knockout Myocardium - pathology peroxisome proliferator-activated receptor ^g Placenta - pathology PPAR^g gene Receptors, Cytoplasmic and Nuclear - agonists Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Thiazoles - pharmacology Thiazolidinediones Transcription Factors - agonists Transcription Factors - genetics Transcription Factors - metabolism
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