Jumping Translocations Involving 11q in a Non-Hodgkin Lymphoma
This paper presents the results of a cytogenetic analysis in an 11-year-old boy with non-Hodgkin lymphoma. The investigation was performed on slides obtained from short-term culture of lymph node cells. The analyses revealed an abnormal clone with loss of the Y, gain of an X chromosome, t(3;22), tri...
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| Veröffentlicht in: | Cancer genetics and cytogenetics 1999-10, Vol.114 (2), p.121-125 |
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| container_title | Cancer genetics and cytogenetics |
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| creator | Petković, Iskra Konja, Josip Dominis, Mara Kaštelan, Maja |
| description | This paper presents the results of a cytogenetic analysis in an 11-year-old boy with non-Hodgkin lymphoma. The investigation was performed on slides obtained from short-term culture of lymph node cells. The analyses revealed an abnormal clone with loss of the Y, gain of an X chromosome, t(3;22), trisomy 11, and three cytogenetically-related subclones with jumping translocations involving 11q13 as the common breakpoint region. This region is an unusual site of chromosome breakage in jumping translocations, and has not been reported thus far. Contrary to most published reports, the jumping translocation in our patient is associated with long survival. |
| doi_str_mv | 10.1016/S0165-4608(99)00056-4 |
| format | Article |
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The investigation was performed on slides obtained from short-term culture of lymph node cells. The analyses revealed an abnormal clone with loss of the Y, gain of an X chromosome, t(3;22), trisomy 11, and three cytogenetically-related subclones with jumping translocations involving 11q13 as the common breakpoint region. This region is an unusual site of chromosome breakage in jumping translocations, and has not been reported thus far. Contrary to most published reports, the jumping translocation in our patient is associated with long survival.</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/S0165-4608(99)00056-4</identifier><identifier>PMID: 10549268</identifier><identifier>CODEN: CGCYDF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aneuploidy ; Biological and medical sciences ; Cells, Cultured ; Child ; Chromosome Breakage - genetics ; Chromosomes, Human, Pair 11 - genetics ; Hematologic and hematopoietic diseases ; Humans ; Karyotyping ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymph Nodes - metabolism ; Lymph Nodes - pathology ; Lymphoma, Non-Hodgkin - diagnosis ; Lymphoma, Non-Hodgkin - genetics ; Lymphoma, Non-Hodgkin - mortality ; Male ; Medical sciences ; Polyploidy ; Prognosis ; Translocation, Genetic - genetics</subject><ispartof>Cancer genetics and cytogenetics, 1999-10, Vol.114 (2), p.121-125</ispartof><rights>1999 Elsevier Science Inc.</rights><rights>1999 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-bd4263ae91ba481eab6ee433ca8364f0da219aba132e1d95489c17747adea2c03</citedby><cites>FETCH-LOGICAL-c390t-bd4263ae91ba481eab6ee433ca8364f0da219aba132e1d95489c17747adea2c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165460899000564$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1994553$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10549268$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petković, Iskra</creatorcontrib><creatorcontrib>Konja, Josip</creatorcontrib><creatorcontrib>Dominis, Mara</creatorcontrib><creatorcontrib>Kaštelan, Maja</creatorcontrib><title>Jumping Translocations Involving 11q in a Non-Hodgkin Lymphoma</title><title>Cancer genetics and cytogenetics</title><addtitle>Cancer Genet Cytogenet</addtitle><description>This paper presents the results of a cytogenetic analysis in an 11-year-old boy with non-Hodgkin lymphoma. The investigation was performed on slides obtained from short-term culture of lymph node cells. The analyses revealed an abnormal clone with loss of the Y, gain of an X chromosome, t(3;22), trisomy 11, and three cytogenetically-related subclones with jumping translocations involving 11q13 as the common breakpoint region. This region is an unusual site of chromosome breakage in jumping translocations, and has not been reported thus far. Contrary to most published reports, the jumping translocation in our patient is associated with long survival.</description><subject>Aneuploidy</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Child</subject><subject>Chromosome Breakage - genetics</subject><subject>Chromosomes, Human, Pair 11 - genetics</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymph Nodes - metabolism</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphoma, Non-Hodgkin - diagnosis</subject><subject>Lymphoma, Non-Hodgkin - genetics</subject><subject>Lymphoma, Non-Hodgkin - mortality</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Polyploidy</subject><subject>Prognosis</subject><subject>Translocation, Genetic - genetics</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAQgC0EouXxE0AZEIIhYMeOEy8gVAEtqmAAZuviXIshids4rcS_x6UVsLHc6XTfPfQRcsToBaNMXj6HkMZC0vxMqXNKaSpjsUX6LM94LEQqt0n_B-mRPe_fA5QlSu6SHqOpUInM--TqYVHPbDONXlpofOUMdNY1Pho1S1ctVw3G5pFtIogeXRMPXTn9CNX4s569uRoOyM4EKo-Hm7xPXu9uXwbDePx0PxrcjGPDFe3iohSJ5ICKFSByhlBIRMG5gZxLMaElJExBAYwnyEqVilwZlmUigxIhMZTvk9P13lnr5gv0na6tN1hV0KBbeC1VwmUi8gCma9C0zvsWJ3rW2hraT82oXonT3-L0yopWSn-L0yLMHW8OLIoayz9Ta1MBONkA4A1Uk6DLWP_LKSXSlAfseo1hsLG02GpvLDYGS9ui6XTp7D-ffAG8KIks</recordid><startdate>19991015</startdate><enddate>19991015</enddate><creator>Petković, Iskra</creator><creator>Konja, Josip</creator><creator>Dominis, Mara</creator><creator>Kaštelan, Maja</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991015</creationdate><title>Jumping Translocations Involving 11q in a Non-Hodgkin Lymphoma</title><author>Petković, Iskra ; Konja, Josip ; Dominis, Mara ; Kaštelan, Maja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-bd4263ae91ba481eab6ee433ca8364f0da219aba132e1d95489c17747adea2c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Aneuploidy</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Child</topic><topic>Chromosome Breakage - genetics</topic><topic>Chromosomes, Human, Pair 11 - genetics</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymph Nodes - metabolism</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphoma, Non-Hodgkin - diagnosis</topic><topic>Lymphoma, Non-Hodgkin - genetics</topic><topic>Lymphoma, Non-Hodgkin - mortality</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Polyploidy</topic><topic>Prognosis</topic><topic>Translocation, Genetic - genetics</topic><toplevel>online_resources</toplevel><creatorcontrib>Petković, Iskra</creatorcontrib><creatorcontrib>Konja, Josip</creatorcontrib><creatorcontrib>Dominis, Mara</creatorcontrib><creatorcontrib>Kaštelan, Maja</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petković, Iskra</au><au>Konja, Josip</au><au>Dominis, Mara</au><au>Kaštelan, Maja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Jumping Translocations Involving 11q in a Non-Hodgkin Lymphoma</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>1999-10-15</date><risdate>1999</risdate><volume>114</volume><issue>2</issue><spage>121</spage><epage>125</epage><pages>121-125</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><coden>CGCYDF</coden><abstract>This paper presents the results of a cytogenetic analysis in an 11-year-old boy with non-Hodgkin lymphoma. The investigation was performed on slides obtained from short-term culture of lymph node cells. The analyses revealed an abnormal clone with loss of the Y, gain of an X chromosome, t(3;22), trisomy 11, and three cytogenetically-related subclones with jumping translocations involving 11q13 as the common breakpoint region. This region is an unusual site of chromosome breakage in jumping translocations, and has not been reported thus far. Contrary to most published reports, the jumping translocation in our patient is associated with long survival.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10549268</pmid><doi>10.1016/S0165-4608(99)00056-4</doi><tpages>5</tpages></addata></record> |
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| ispartof | Cancer genetics and cytogenetics, 1999-10, Vol.114 (2), p.121-125 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Collection |
| subjects | Aneuploidy Biological and medical sciences Cells, Cultured Child Chromosome Breakage - genetics Chromosomes, Human, Pair 11 - genetics Hematologic and hematopoietic diseases Humans Karyotyping Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymph Nodes - metabolism Lymph Nodes - pathology Lymphoma, Non-Hodgkin - diagnosis Lymphoma, Non-Hodgkin - genetics Lymphoma, Non-Hodgkin - mortality Male Medical sciences Polyploidy Prognosis Translocation, Genetic - genetics |
| title | Jumping Translocations Involving 11q in a Non-Hodgkin Lymphoma |
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