Differential MUC 1 expression in normal and neoplastic human pancreatic tissue : An immunohistochemical study of 60 samples
Neoplastic transformation of epithelial cell sis commonly associated with altered synthesis of mucin glycoproteins. Few studies have been performed on the correlation between MUC 1 expression and pancreatic carcinoma using immunohistochemical methods. We compared the patterns of MUC 1 expression in...
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| Veröffentlicht in: | American journal of clinical pathology 1999-11, Vol.112 (5), p.635-640 |
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| container_title | American journal of clinical pathology |
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| creator | MONGES, G. M MATHOULIN-PORTIER, M.-P. A ACRES, I. R. B HOUVENAEGHEL, G. F GIOVANNINI, M. F SEITZ, J.-F BARDOU, V.-J PAYAN, M.-J. M OLIVE, D |
| description | Neoplastic transformation of epithelial cell sis commonly associated with altered synthesis of mucin glycoproteins. Few studies have been performed on the correlation between MUC 1 expression and pancreatic carcinoma using immunohistochemical methods. We compared the patterns of MUC 1 expression in normal pancreatic tissue, in pancreatic carcinoma, and in chronic pancreatitis. Immunohistochemical studies were performed using 3 monoclonal anti-MUC 1 antibodies (12C10, 1G5, and H23) on surgical specimens and on fine-needle aspiration biopsy specimens. In the neoplastic cells from adenocarcinomas, high levels of cytoplasmic MUC 1 expression were observed, with some membrane staining. No such cytoplasmic expression was observed in normal tissue, tissue from chronic pancreatitis, or benign neoplastic tissue. These data show conspicuous quantitative and qualitative differences between the patterns of MUC 1 expression observed in nonmalignant vs malignant pancreatic tissue and may be useful in the histologic diagnosis of adenocarcinoma in biopsy samples. |
| doi_str_mv | 10.1093/ajcp/112.5.635 |
| format | Article |
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M ; MATHOULIN-PORTIER, M.-P. A ; ACRES, I. R. B ; HOUVENAEGHEL, G. F ; GIOVANNINI, M. F ; SEITZ, J.-F ; BARDOU, V.-J ; PAYAN, M.-J. M ; OLIVE, D</creator><creatorcontrib>MONGES, G. M ; MATHOULIN-PORTIER, M.-P. A ; ACRES, I. R. B ; HOUVENAEGHEL, G. F ; GIOVANNINI, M. F ; SEITZ, J.-F ; BARDOU, V.-J ; PAYAN, M.-J. M ; OLIVE, D</creatorcontrib><description>Neoplastic transformation of epithelial cell sis commonly associated with altered synthesis of mucin glycoproteins. Few studies have been performed on the correlation between MUC 1 expression and pancreatic carcinoma using immunohistochemical methods. We compared the patterns of MUC 1 expression in normal pancreatic tissue, in pancreatic carcinoma, and in chronic pancreatitis. Immunohistochemical studies were performed using 3 monoclonal anti-MUC 1 antibodies (12C10, 1G5, and H23) on surgical specimens and on fine-needle aspiration biopsy specimens. In the neoplastic cells from adenocarcinomas, high levels of cytoplasmic MUC 1 expression were observed, with some membrane staining. No such cytoplasmic expression was observed in normal tissue, tissue from chronic pancreatitis, or benign neoplastic tissue. These data show conspicuous quantitative and qualitative differences between the patterns of MUC 1 expression observed in nonmalignant vs malignant pancreatic tissue and may be useful in the histologic diagnosis of adenocarcinoma in biopsy samples.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1093/ajcp/112.5.635</identifier><identifier>PMID: 10549250</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Antibodies, Monoclonal ; Biological and medical sciences ; Biopsy ; Carcinoma, Acinar Cell - metabolism ; Carcinoma, Acinar Cell - pathology ; Carcinoma, Ductal, Breast - metabolism ; Carcinoma, Ductal, Breast - pathology ; Cystadenoma, Mucinous - metabolism ; Cystadenoma, Mucinous - pathology ; Diagnosis, Differential ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Immunoenzyme Techniques ; Liver. Biliary tract. Portal circulation. 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M</creatorcontrib><creatorcontrib>MATHOULIN-PORTIER, M.-P. A</creatorcontrib><creatorcontrib>ACRES, I. R. B</creatorcontrib><creatorcontrib>HOUVENAEGHEL, G. F</creatorcontrib><creatorcontrib>GIOVANNINI, M. F</creatorcontrib><creatorcontrib>SEITZ, J.-F</creatorcontrib><creatorcontrib>BARDOU, V.-J</creatorcontrib><creatorcontrib>PAYAN, M.-J. M</creatorcontrib><creatorcontrib>OLIVE, D</creatorcontrib><title>Differential MUC 1 expression in normal and neoplastic human pancreatic tissue : An immunohistochemical study of 60 samples</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>Neoplastic transformation of epithelial cell sis commonly associated with altered synthesis of mucin glycoproteins. Few studies have been performed on the correlation between MUC 1 expression and pancreatic carcinoma using immunohistochemical methods. We compared the patterns of MUC 1 expression in normal pancreatic tissue, in pancreatic carcinoma, and in chronic pancreatitis. Immunohistochemical studies were performed using 3 monoclonal anti-MUC 1 antibodies (12C10, 1G5, and H23) on surgical specimens and on fine-needle aspiration biopsy specimens. In the neoplastic cells from adenocarcinomas, high levels of cytoplasmic MUC 1 expression were observed, with some membrane staining. No such cytoplasmic expression was observed in normal tissue, tissue from chronic pancreatitis, or benign neoplastic tissue. These data show conspicuous quantitative and qualitative differences between the patterns of MUC 1 expression observed in nonmalignant vs malignant pancreatic tissue and may be useful in the histologic diagnosis of adenocarcinoma in biopsy samples.</description><subject>Antibodies, Monoclonal</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Carcinoma, Acinar Cell - metabolism</subject><subject>Carcinoma, Acinar Cell - pathology</subject><subject>Carcinoma, Ductal, Breast - metabolism</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Cystadenoma, Mucinous - metabolism</subject><subject>Cystadenoma, Mucinous - pathology</subject><subject>Diagnosis, Differential</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Mucin-1 - metabolism</subject><subject>Pancreas - cytology</subject><subject>Pancreas - metabolism</subject><subject>Pancreatic Neoplasms - metabolism</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatitis - metabolism</subject><subject>Pancreatitis - pathology</subject><subject>Tumors</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1r3DAQhkVoSLZprz0WHUpv3uhjJUu9he0nJPTSnIUsj1kFS3Y1NiT0z1fLLrSngZnnfWEeQt5xtuXMylv_FOZbzsVWbbVUF2TD7U42bSvEK7JhjInG8lZek9eIT4xxYdjuilxzpnZWKLYhfz7HYYACeYl-pA-Pe8opPM8FEOOUacw0TyXVk889zTDNo8clBnpYk8909jkU8MfFEhFXoJ_oXU2ltObpEHGZwgFSDDWPy9q_0GmgmlH0aR4B35DLwY8Ib8_zhjx-_fJr_725__ntx_7uvglSs6XpDbBOm05ZawXvrGlBCyulqtfBa2nYEIzpg_JWge1NCKAN2E5rMGZnubwhH0-9c5l-r4CLSxEDjKOvD63otBVSC34EtycwlAmxwODmEpMvL44zd9Ttjrpd1e2Uq7pr4P25ee0S9P_hJ78V-HAGPFYLQ6nCIv7jrOGiNfIvAteJNA</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>MONGES, G. 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Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Mucin-1 - metabolism</topic><topic>Pancreas - cytology</topic><topic>Pancreas - metabolism</topic><topic>Pancreatic Neoplasms - metabolism</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pancreatitis - metabolism</topic><topic>Pancreatitis - pathology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MONGES, G. M</creatorcontrib><creatorcontrib>MATHOULIN-PORTIER, M.-P. A</creatorcontrib><creatorcontrib>ACRES, I. R. B</creatorcontrib><creatorcontrib>HOUVENAEGHEL, G. F</creatorcontrib><creatorcontrib>GIOVANNINI, M. F</creatorcontrib><creatorcontrib>SEITZ, J.-F</creatorcontrib><creatorcontrib>BARDOU, V.-J</creatorcontrib><creatorcontrib>PAYAN, M.-J. 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M</au><au>OLIVE, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential MUC 1 expression in normal and neoplastic human pancreatic tissue : An immunohistochemical study of 60 samples</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>112</volume><issue>5</issue><spage>635</spage><epage>640</epage><pages>635-640</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>Neoplastic transformation of epithelial cell sis commonly associated with altered synthesis of mucin glycoproteins. Few studies have been performed on the correlation between MUC 1 expression and pancreatic carcinoma using immunohistochemical methods. We compared the patterns of MUC 1 expression in normal pancreatic tissue, in pancreatic carcinoma, and in chronic pancreatitis. 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| subjects | Antibodies, Monoclonal Biological and medical sciences Biopsy Carcinoma, Acinar Cell - metabolism Carcinoma, Acinar Cell - pathology Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology Cystadenoma, Mucinous - metabolism Cystadenoma, Mucinous - pathology Diagnosis, Differential Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoenzyme Techniques Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Mucin-1 - metabolism Pancreas - cytology Pancreas - metabolism Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pancreatitis - metabolism Pancreatitis - pathology Tumors |
| title | Differential MUC 1 expression in normal and neoplastic human pancreatic tissue : An immunohistochemical study of 60 samples |
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